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Electroacupuncture Regulates Endoplasmic Reticulum Stress and Ameliorates Neuronal Injury in Rats with Acute Ischemic Stroke
This study aimed to determine whether endoplasmic reticulum stress (ERS) could contribute to the protective effects of EA in cerebral ischemia/reperfusion injury (CIRI) to provide a rationale for the widespread clinical use of EA. Rats were divided into the sham-operated (sham) group, the CIRI (model) group, and the EA group. Rats in the model group were subjected to middle cerebral artery occlusion (MCAO) for 2 h followed by 72 h of reperfusion. Rats with CIRI were treated daily with EA at GV20 and ST36 for a total of 3 days. The Longa scoring system and adhesive removal somatosensory test were applied to evaluate neurolo...
Source: Evidence-based Complementary and Alternative Medicine - August 26, 2021 Category: Complementary Medicine Authors: Ya-Min Zhang Hong Xu Su-Hui Chen Hua Sun Source Type: research

Systematic Understanding of Mechanism of Danggui Shaoyao San against Ischemic Stroke Using a Network Pharmacology Approach
CONCLUSIONS: This study showed that DSS can treat IS through multiple targets and routes and provided new insights to explore the mechanisms of DSS against IS.PMID:35035503 | PMC:PMC8754614 | DOI:10.1155/2022/3747285
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2022 Category: Complementary Medicine Authors: Sijie Li Yong Yang Wei Zhang Haiyan Li Wantong Yu Chen Gao Jiali Xu Wenbo Zhao Changhong Ren Source Type: research

Neuroprotective Effect of Moxibustion on Cerebral Ischemia/Reperfusion Injury in Rats by Downregulating NR2B Expression
CONCLUSIONS: Moxibustion can improve neurological dysfunction and decrease infarction area and neuronal apoptosis caused by cerebral ischemia/reperfusion in rats. Its neuroprotective mechanism may be related to downregulating the expression of NR2B.PMID:34733340 | PMC:PMC8560262 | DOI:10.1155/2021/5370214
Source: Evidence-based Complementary and Alternative Medicine - November 4, 2021 Category: Complementary Medicine Authors: Zhong Di Qin Guo Quanai Zhang Source Type: research

Roots of < em > Astragalus propinquus < /em > Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia-Reperfusion Injury
CONCLUSION: RAP stimulation inhibited ferroptosis by regulating the expression of the key ferroptosis factors XCT, SLC3A2, GPX4, NRF2, HO-1, and IREB2. In conclusion, RAP regulates transmembrane iron transport and ferroptosis to improve CIRI.PMID:35958925 | PMC:PMC9363172 | DOI:10.1155/2022/7410865
Source: Evidence-based Complementary and Alternative Medicine - August 12, 2022 Category: Complementary Medicine Authors: Juan Chen Donglai Ma Jun Bao Ying Zhang Guoxing Deng Source Type: research

Efficacy of Fuyuan Xingshen Decoction Combined with Butylphthalide Sodium Chloride Injection in the Treatment of Acute Cerebral Infarction and Its Effect on Hemodynamics
CONCLUSIONS: Fuyuan Xingshen Decoction combined with butylphthalide sodium chloride injection can effectively improve patients' daily living ability, neurological function, cognitive function, and cerebral hemodynamics in the treatment of ACI, with good effect and safety.PMID:36193139 | PMC:PMC9526653 | DOI:10.1155/2022/2402040
Source: Evidence-based Complementary and Alternative Medicine - October 4, 2022 Category: Complementary Medicine Authors: Jiangang Ji Kai Yu Xinyu Zhang Wenting Liu Source Type: research