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Source: International Journal of Molecular Medicine
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Total 10 results found since Jan 2013.
Damage to the blood ‑brain barrier and activation of neuroinflammation by focal cerebral ischemia under hyperglycemic condition
Int J Mol Med. 2021 Jul;48(1):142. doi: 10.3892/ijmm.2021.4975. Epub 2021 Jun 3.ABSTRACTHyperglycemia aggravates brain damage caused by cerebral ischemia/reperfusion (I/R) and increases the permeability of the blood‑brain barrier (BBB). However, there are relatively few studies on morphological changes of the BBB. The present study aimed to investigate the effect of hyperglycemia on BBB morphological changes following cerebral I/R injury. Streptozotocin‑induced hyperglycemic and citrate‑buffered saline‑injected normoglycemic rats were subjected to 30 min middle cerebral artery occlusion. Neurological deficits were ...
Source: International Journal of Molecular Medicine - June 3, 2021 Category: Molecular Biology Authors: Yongzhen Guo Lingdi Dong Ao Gong Jingwen Zhang Li Jing Tomas Ding Ping-An Andy Li Jian-Zhong Zhang Source Type: research
