• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Role of 20-HETE,TRP channels & BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.
Role of 20-HETE,TRP channels & BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice. Am J Physiol Heart Circ Physiol. 2013 Oct 4; Authors: Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Laniado Schwartzman M, Sonntag WE, Ungvari ZI Abstract Hypertension in the elderly substantially increases the risk stroke and vascular cognitive impairment (VCI) in part due to an impaired functional adaptation of aged cerebral arteries to high blood pressure. To elucidate the mechanisms underlying impaired autoregulatory protec...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 4, 2013 Category: Physiology Authors: Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Laniado Schwartzman M, Sonntag WE, Ungvari ZI Tags: Am J Physiol Heart Circ Physiol Source Type: research

The Effects of Hypertension on the Cerebral Circulation.
Abstract Maintenance of brain function depends on a constant blood supply. Deficits in cerebral blood flow are linked to cognitive decline, and they have detrimental effects on the outcome of ischemia. Hypertension causes alterations in cerebral artery structure and function that can impair blood flow particularly during an ischemic insult, or during periods of low arterial pressure. This review will focus on the historical discoveries, novel developments and knowledge gaps in: 1) hypertensive cerebral artery remodeling; 2) vascular function, with emphasis on myogenic reactivity and endothelium-dependent dilation;...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2013 Category: Physiology Authors: Pires PW, Dams Ramos CM, Matin N, Dorrance AM Tags: Am J Physiol Heart Circ Physiol Source Type: research

Inotropic and Lusitropic Effects of Calcitonin Gene-Related Peptide in the Heart.
Abstract Previous studies have demonstrated positive-inotropic effects of calcitonin gene-related peptide (CGRP) but the mechanisms remain unclear. Therefore, two experiments were performed to determine the physiological correlates of the positive-inotropic effects of CGRP. Treatments designed to antagonize the effects of physiologically-active CGRP 1-37 included post-treatment with CGRP8-37 and pretreatment with LY294002 (LY, an inhibitor of PI3K), 17β-estradiol (E) and progesterone (P) were also used to modulate the effects of CGRP1-37. Experiment 1: In vitro studies on sarcomeres and cells of isolated adult ra...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2013 Category: Physiology Authors: Al-Rubaiee M, Gangula PR, Millis RM, Walker RK, Umoh NA, Cousins VM, Jeffress MA, Haddad GE Tags: Am J Physiol Heart Circ Physiol Source Type: research

Pages: 1  2  3  4