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A short review of proprotein convertase subtilisin/kexin type 9 inhibitors.
Authors: Alali RA Abstract Cardiovascular disease is the leading cause of morbidity and mortality globally, as estimated by the World Health Organization, where in 2016, 15.2 million deaths were attributed to ischemic heart disease and stroke. It is therefore essential to try to reduce the incidence of Cardiovascular disease by controlling modifiable risk factors. One such major modifiable risk factor is cholesterol, which influences the pathogenesis and progression of atherosclerosis. Statins are often prescribed to lower blood levels of low density lipoprotein cholesterol, thereby reducing the risk of Cardiovascu...
Source: Reviews in Cardiovascular Medicine - June 13, 2019 Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research

UK heart disease and stroke death rates now lower than cancer
Conclusion This valuable research informs on the burden of cardiovascular disease and associated mortality across European countries. It demonstrates that CVD is still the most common cause of death across Europe, but rates have been falling over the past 10 years. This fall means that in several European countries, including the UK, cancer rates now overtake CVD death rates in men. Generally, CVD disability and burden of disease seems to be greater in Eastern European countries. The WHO mortality data and population data are quite up-to-date and should be reliable, though as the researchers say, there was a lack of high ...
Source: NHS News Feed - August 15, 2016 Category: Consumer Health News Tags: Heart/lungs Cancer Neurology Source Type: news

Adherence to Medical Therapy and the Global Burden of Cardiovascular Disease ∗
Ischemic heart disease and cerebrovascular disease account for>20% of worldwide mortality and are the 2 leading causes of death on a global basis (1). Although mortality from ischemic heart disease is greater than that from stroke worldwide, the mortality from stroke is actually higher than from ischemic heart disease in 39% of countries. For example, mortality from stroke is generally higher than that for ischemic heart disease in China, Africa, and South America. In addition, stroke disability–adjusted life-year loss rates exceed ischemic heart disease-related disability in 32% of countries (2). Because of this, strate...
Source: Journal of the American College of Cardiology - March 29, 2016 Category: Cardiology Source Type: research

Studies support broader use of cholesterol-lowering statins
The latest guidelines used to determine who should take a cholesterol-lowering statin to prevent heart disease appear to be more accurate and cost-efficient than the previous guidelines. That’s according to two studies led by Harvard researchers, both published in this week’s Journal of the American Medical Association. For many years, the main deciding factor in who needed to take a statin was the level of an individual’s harmful low-density lipoprotein cholesterol (LDL). Updated guidelines published in 2013 by the American College of Cardiology and the American Heart Association moved away from LDL and ...
Source: New Harvard Health Information - July 16, 2015 Category: Consumer Health News Authors: Julie Corliss Tags: Drugs and Supplements cholesterol high cholesterol statins Source Type: news