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Cardiovascular comorbidities in atopic dermatitis: Potential implications for the use of Janus kinase inhibitors
To the Editor: The Food and Drug Administration recently approved the use of 2 oral Janus kinase (JAK) inhibitors —abrocitinib and upadacitinib—for patients with moderate-to-severe atopic dermatitis (AD) not adequately controlled with systemic therapies, including biologics, or when the use of such treatments is inadvisable.1,2 In September 2021, the Food and Drug Administration issued a boxed warning for a ll JAK inhibitors regarding the increased risk of serious infections, heart attack, stroke, cancer, blood clots, and death.
Source: Journal of the American Academy of Dermatology - August 19, 2023 Category: Dermatology Authors: J. Mark Jackson, Amanda Althoff, Lawrence Rasouliyan, Stacey Long, Carla L. Zema Tags: Research letter Source Type: research

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury Neuroscience
Recombinant tissue plasminogen activator (tPA) is a Food and Drug Administration-approved thrombolytic treatment for ischemic stroke. tPA is also naturally expressed in glial and neuronal cells of the brain, where it promotes axon outgrowth and synaptic plasticity. However, there are conflicting reports of harmful versus neuroprotective effects of tPA in...
Source: Proceedings of the National Academy of Sciences - September 25, 2018 Category: Science Authors: Yuguo Xia, Hongjian Pu, Rehana K. Leak, Yejie Shi, Hongfeng Mu, Xiaoming Hu, Zhengyu Lu, Lesley M. Foley, T. Kevin Hitchens, C. Edward Dixon, Michael V. L. Bennett, Jun Chen Tags: PNAS Plus Source Type: research

3 reasons your child shouldn’t go “gluten-free” (unless your doctor says so)
Follow me at @drClaire There is a puzzling and worrisome new phenomenon that I am seeing as a pediatrician: parents who are putting their children on gluten-free diets. It’s puzzling because in the vast majority of cases it isn’t necessary — and it’s worrisome because, although parents are doing it because they think it’s healthy, a gluten-free diet can be very unhealthy for children. Gluten is a protein found in wheat, rye, barley, and some other grains. It’s in bread and other baked goods, cereals, pastas — and in many other foods in small amounts. For people with celiac disease, even those small amounts ca...
Source: New Harvard Health Information - June 7, 2016 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Healthy Eating Parenting Source Type: news

Development of the Trevo ProVue Retriever for intracranial clot removal in acute ischemic stroke
It is estimated that 15 million people worldwide have a stroke each year. Of the estimated 795,000 strokes that occur in the United States annually, the majority are ischemic strokes resulting from an obstruction within a vessel supplying blood to the brain. The treatment goal for these patients is to restore blood flow as quickly as possible. Increasingly, endovascular treatments that interact directly with the clot are being pursued as options. Receiving U.S. Food and Drug Administration clearance in 2012, the Trevo® Retriever is a stent‐like structure to be deployed at the site of an occlusion to allow the occluding ...
Source: Annals of the New York Academy of Sciences - November 14, 2014 Category: Science Authors: Heather C. Prince, Amelia J. Saliba, Jaime Wheeler, Scott Bruder Tags: Original Article Source Type: research

Phases in development of an interactive mobile phone-based system to support self-management of hypertension
Inger Hallberg,1,11 Charles Taft,1,11 Agneta Ranerup,2,11 Ulrika Bengtsson,1,11 Mikael Hoffmann,3,10 Stefan Höfer,4 Dick Kasperowski,5 Åsa Mäkitalo,6 Mona Lundin,6 Lena Ring,7,8 Ulf Rosenqvist,9 Karin Kjellgren1,10,11 1Institute of Health and Care Sciences, 2Department of Applied Information Technology, University of Gothenburg, Gothenburg, 3The NEPI Foundation, Linköping, Sweden; 4Department of Medical Psychology, Innsbruck Medical University, Innsbruck, Austria; 5Department of Philosophy, Linguistics and Theory of Science, 6Department of Education, Communication and Learning, University of Gothenburg...
Source: Integrated Blood Pressure Control - May 6, 2014 Category: Cardiology Tags: Integrated Blood Pressure Control Source Type: research