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Catheter Ablation for Atrial Fibrillation
Atrial fibrillation (AF) is the most common heart rhythm disturbance, with an estimated 33.5 million people affected worldwide. By age 75 years, more than 10% of the population will have developed AF. It is well recognized that AF increases the risk of thromboembolic stroke; however, AF also increases the risk of other highly morbid conditions such as heart failure (HF). As a result, even in the modern era of anticoagulation, mortality rates among patients with AF remain up to 2-fold higher than mortality rates among individuals without AF. For many patients, AF also has a major detrimental effect on quality of life, simil...
Source: JAMA - Journal of the American Medical Association - March 15, 2019 Category: General Medicine Source Type: research

Bivalirudin vs Heparin With or Without Tirofiban During Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction The BRIGHT Randomized Clinical Trial
ImportanceThe safety and efficacy of bivalirudin compared with heparin with or without glycoprotein IIb/IIIa inhibitors in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) are uncertain.ObjectiveTo determine if bivalirudin is superior to heparin alone and to heparin plus tirofiban during primary PCI.Design, Setting, and ParticipantsMulticenter, open-label trial involving 2194 patients with AMI undergoing primary PCI at 82 centers in China between August 2012 and June 2013.InterventionsPatients were randomly assigned to receive bivalirudin with a post-PCI infusion (...
Source: JAMA - Journal of the American Medical Association - March 16, 2015 Category: Journals (General) Source Type: research