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Deep Brain Stimulation May Improve Function Years After Stroke
After deep brain stimulation (DBS) of the cerebellar dentate nucleus, a brain region involved in control of voluntary movements, 9 out of 12 patients who had experienced a stroke up to 3 years earlier experienced clinically important improvements in motor function and decreases in impairment, according to results from a phase 1 trial published in Nature Medicine.
Source: JAMA - Journal of the American Medical Association - August 30, 2023 Category: General Medicine Source Type: research

BA1 Bivalent COVID-19 Vaccine Use and Stroke in England
This study investigates the association between bivalent COVID-19 vaccines and ischemic stroke, as well as the effect of simultaneous influenza vaccination on the association.
Source: JAMA - Journal of the American Medical Association - June 15, 2023 Category: General Medicine Source Type: research

WHO: Nations Must Do More to Reduce Salt Consumption by 2025
In 2013, 194 countries committed to a World Health Organization (WHO) goal of reducing global sodium intake, which in excess can increase people ’s risk of heart disease, stroke, and premature death, by 30% by 2025. A report published by the WHO, however, showed that the world is not on track to meet that target.
Source: JAMA - Journal of the American Medical Association - March 22, 2023 Category: General Medicine Source Type: research

Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease
This randomized clinical trial compares the efficacy of a treat-to-target low-density lipoprotein cholesterol (LDL-C) strategy of 50 to 70 mg/dL as the goal vs high-intensity statin therapy for the 3-year composite of death, myocardial infarction, stroke, or coronary revascularization in patients with coronary artery disease.
Source: JAMA - Journal of the American Medical Association - March 6, 2023 Category: General Medicine Source Type: research

Effect of Argatroban Plus Alteplase vs Alteplase on Neurologic Function After Acute Ischemic Stroke
This randomized clinical trial examines the efficacy of argatroban plus altepase for acute ischemic stroke within 4.5 hours from onset.
Source: JAMA - Journal of the American Medical Association - February 9, 2023 Category: General Medicine Source Type: research

Stroke Risk From Diabetes, High Blood Pressure May Decrease With Age
Research appearing in Neurology found that the risk for stroke due to select factors was lower in magnitude at older ages.
Source: JAMA - Journal of the American Medical Association - January 25, 2023 Category: General Medicine Source Type: research

Acute Myocardial Infarction and Ischemic Stroke After COVID-19 by Vaccination Status
This retrospective cohort study examines the incidence of acute myocardial infarction and ischemic stroke after COVID-19 infection among vaccinated vs unvaccinated adults in Korea.
Source: JAMA - Journal of the American Medical Association - July 22, 2022 Category: General Medicine Source Type: research

Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine
This population based study evaluated the short-term risk of severe cardiovascular risks among French residents 75 years or older after they received the BNT162b2 mRNA vaccination.
Source: JAMA - Journal of the American Medical Association - November 22, 2021 Category: General Medicine Source Type: research

Temporal Trends in Stroke Thrombolysis in the US by Race and Ethnicity, 2009-2018
This study investigates the temporal trend in racial and ethnic differences in use of intravenous thrombolysis for stroke treatment between 2009 and 2018 in a representative sample of US adults.
Source: JAMA - Journal of the American Medical Association - October 11, 2021 Category: General Medicine Source Type: research

Intensive Medical Management to Prevent Large and Small Artery Atherothrombotic Stroke
This Viewpoint examines the potential of using newer strategies to prevent ischemic stroke due to large and small artery atherothrombosis, including agents to lower LDL cholesterol, as well as increase eicosapentaenoic acid levels, insulin sensitivity and synthesis, and folic acid levels.
Source: JAMA - Journal of the American Medical Association - July 1, 2021 Category: General Medicine Source Type: research

Changes in Patterns of Acute MI or Ischemic Stroke Hospitalization During COVID-19 Surges
This study evaluates changes in rates of patients hospitalized for acute myocardial infarction (AMI) or suspected stroke during COVID-19 surges in the US as a measure of willingness to seek care during the pandemic.
Source: JAMA - Journal of the American Medical Association - June 2, 2021 Category: General Medicine Source Type: research

National Initiatives to Prevent Myocardial Infarction and Stroke
This Viewpoint discusses the Million Hearts initiative, a national effort that aims to prevent a million myocardial infarctions and strokes over 5 years, and proposes actions and strategies federal agencies can take to advance tobacco control, sodium reduction, trans fat elimination, hypertension control, and centering the US health care system on primary care.
Source: JAMA - Journal of the American Medical Association - March 12, 2021 Category: General Medicine Source Type: research

Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19
This JAMA Insights review summarizes the pathophysiology underlying the thrombotic diathesis characteristic of acute SARS-CoV-2 infection and current recommendations for the prevention, diagnosis, and management of the most common thrombotic complications in COVID-19, including acute myocardial infarction (AMI), ischemic stroke, and venous thromboembolism (VTE).
Source: JAMA - Journal of the American Medical Association - November 23, 2020 Category: General Medicine Source Type: research

Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Ischemic Stroke
This randomized clinical trial compares the effects of 2 tenecteplase doses (0.40 vs 0.25 mg/kg) prior to endovascular thrombectomy on blood flow restoration to brain ischemic territory in patients with large vessel occlusion ischemic stroke.
Source: JAMA - Journal of the American Medical Association - February 20, 2020 Category: General Medicine Source Type: research

Cardiovascular Corner: Prescription Omega-3s, Stroke Rehab, and Statins After Age 75
This Medical News article is an update on important clinical research in the world of heart disease and stroke.
Source: JAMA - Journal of the American Medical Association - September 11, 2019 Category: General Medicine Source Type: research

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