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CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling
Transl Res. 2023 Feb 12:S1931-5244(23)00022-1. doi: 10.1016/j.trsl.2023.01.007. Online ahead of print.ABSTRACTAccording to previous studies, circular RNAs (circRNAs) are involved in multiple pathological processes of acute ischemic stroke (AIS). However, the relationship between circFOXP1 and IS has not yet been reported. Here, we found that circFOXP1 expression was significantly decreased in the peripheral blood of AIS patients compared to controls and was associated with the severity and prognosis of AIS. Functionally, knockdown and overexpression of circFOXP1 promoted and inhibited apoptotic signaling, respectively, fol...
Source: Translational Research : the journal of laboratory and clinical medicine - February 14, 2023 Category: Laboratory Medicine Authors: Jialei Yang Wanting He Lian Gu Lulu Zhu Tian Liang Xueying Liang Qingqing Zhong Ruirui Zhang Aruo Nan Li Su Source Type: research