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Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
Lancet Respir Med. 2021 Jul 27:S2213-2600(21)00310-6. doi: 10.1016/S2213-2600(21)00310-6. Online ahead of print.ABSTRACTBACKGROUND: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes.METHODS: We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK. We included peo...
Source: Respiratory Care - July 30, 2021 Category: Respiratory Medicine Authors: Christopher C Butler Ly-Mee Yu Jienchi Dorward Oghenekome Gbinigie Gail Hayward Benjamin R Saville Oliver Van Hecke Nicholas Berry Michelle A Detry Christina Saunders Mark Fitzgerald Victoria Harris Ratko Djukanovic Stephan Gadola John Kirkpatrick Simon d Source Type: research