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Specialty: Allergy & Immunology
Infectious Disease: Chagas Disease
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IL-1 β is not critical to chronic heart dysfunction in mice with Chagas disease
In conclusion, the absence of functional IL-1β/IL-1R signaling did not prevent or reverse the decrease of SV or the incidence of cardiac arrhythmias induced by chronic T. cruzi infection, implying this is not a critical mechanism in generating or maintaining CCC. Since similar cardiac abnormalities were previously credited to IL-1β signaling, ruling out this mechanism is important to discourage further attempts of IL-1β blockade as a therapeutical measure.
Source: Frontiers in Immunology - October 14, 2022 Category: Allergy & Immunology Source Type: research
