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cDNA cloning of a snake venom metalloproteinase from the eastern diamondback rattlesnake (Crotalus adamanteus), and the expression of its disintegrin domain with anti-platelet effects.
Abstract A 5' truncated snake venom metalloproteinase was identified from a cDNA library constructed from venom glands of an eastern diamondback rattlesnake (Crotalus adamanteus). The 5'-rapid amplification of cDNA ends (RACE) was used to obtain the 1865 bp full-length cDNA sequence of a snake venom metalloproteinase (CamVMPII). CamVMPII encodes an open reading frame of 488 amino acids, which includes a signal peptide, a pro-domain, a metalloproteinase domain, a spacer, and an RGD-disintegrin domain. The predicted amino acid sequence of CamVMPII showed a 91%, 90%, 83%, and 82% sequence homology to the P-II class e...
Source: Toxicon - January 10, 2013 Category: Toxicology Authors: Suntravat M, Jia Y, Lucena SE, Sánchez EE, Pérez JC Tags: Toxicon Source Type: research

Incidence of fatal snake bite in Australia: A coronial based retrospective study (2000-2016).
CONCLUSIONS: Death from snake bite remains rare in Australia, and has maintained a steady rate for over 20 years. Usually considered a 'rural issue', and with varying recorded causes of death, a nationally co-ordinated effort to further review the national picture of envenoming in Australia can inform education and resource needs within state and local contexts. PMID: 28288937 [PubMed - as supplied by publisher]
Source: Toxicon - March 9, 2017 Category: Toxicology Authors: Welton R, Liew D, Braitberg G Tags: Toxicon Source Type: research