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Maternal levels of Epstein-Barr virus IgG antibodies and risk of multiple sclerosis in offspring in the Finnish Maternity Cohort (S44.006)
Conclusions:Elevated maternal levels of VCA IgG are associated with an increased risk of MS in the offspring. Further studies are needed to elucidate potential biological mechanisms.Study Supported by: This study was funded by the National Institute of Neurological Disorders and Stroke (NIH R01 NS073633, PI: Ascherio).Disclosure: Dr. Munger has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Aivo has nothing to disclose. Dr. Hongell has nothing to disclose. Dr. Soilu-Hanninen has nothing to disclose. Dr. Surcel has nothing to disclose. Dr. Ascherio has received personal compensation for activities with Almirall...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Munger, K., Zhang, Z., Aivo, J., Hongell, K., Soilu-Hanninen, M., Surcel, H.-M., Ascherio, A. Tags: MS Risk Factors and Modifications Source Type: research

Concentration Dependent Inhibitory Effect of a Nucleoside-based Analog Against Human Herpesvirus-6 Replication (P6.304)
Human herpesvirus-6 (HHV-6) is associated with a number neurological disorders including multiple sclerosis (MS). To test the hypothesis of HHV-6 association in MS, certain approved human herpesvirus therapies have been investigated for treatment against HHV-6 in MS patients. However, antiviral therapies specific for HHV-6 do not exist. Therefore, antivirals that primarily targert other β-herpesviruses such as human cytomegalovirus (HCMV) are often used in these trials but with minimal efficacy. Recently, a subset of nucleoside-based analogs was reported with improved efficacy against herpesviruses. Therefore, our goa...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lee, N., Leibovitch, E., Jacobson, S. Tags: HTLV and Other Viral Infections Source Type: research

Infectious burden and cognitive function: The Northern Manhattan Study
Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
Source: Neurology - March 25, 2013 Category: Neurology Authors: Katan, M., Moon, Y. P., Paik, M. C., Sacco, R. L., Wright, C. B., Elkind, M. S. V. Tags: All Infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia ARTICLE Source Type: research

Primary Central Nervous System Vasculitis Triggered by Cytomegalovirus Encephalitis (P01.231)
CONCLUSIONS: Our case is the first reported case in the literature of proven CMV encephalitis triggering a subsequent non-infectious CNS vasculitis probably secondary to an autoimmune response. The absence of findings in the initial MRIs of the brain in spite of an intermittently symptomatic patient and the subsequent development of ischemic infarcts supports the theory of intermittent focal hypoperfusion, finally leading to infarction. The high clinical suspicion even with lack of clear evidence of the disease process and empirical treatment led to a successful clinical recovery.Disclosure: Dr. Rosales has nothing to disc...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Rosales, D., Garcia-Gracia, C., Salgado, E., Salanga, V. Tags: P01 Cerebrovascular Disease I Source Type: research