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Maternal levels of Epstein-Barr virus IgG antibodies and risk of multiple sclerosis in offspring in the Finnish Maternity Cohort (S44.006)
Conclusions:Elevated maternal levels of VCA IgG are associated with an increased risk of MS in the offspring. Further studies are needed to elucidate potential biological mechanisms.Study Supported by: This study was funded by the National Institute of Neurological Disorders and Stroke (NIH R01 NS073633, PI: Ascherio).Disclosure: Dr. Munger has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Aivo has nothing to disclose. Dr. Hongell has nothing to disclose. Dr. Soilu-Hanninen has nothing to disclose. Dr. Surcel has nothing to disclose. Dr. Ascherio has received personal compensation for activities with Almirall...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Munger, K., Zhang, Z., Aivo, J., Hongell, K., Soilu-Hanninen, M., Surcel, H.-M., Ascherio, A. Tags: MS Risk Factors and Modifications Source Type: research

What Genetics are Associated with Multiple Sclerosis?
Discussion Multiple sclerosis (MS) is “a chronic degenerative, often episodic disease of the central nervous system marked by patchy destruction of the myelin that surrounds and insulates nerve fibers, usually appearing in young adulthood and manifested by one or more mild to severe neural and muscular impairments, as spastic weakness in one or more limbs, local sensory losses, bladder dysfunction, or visual disturbances.” It is a chronic disease and therefore symptoms must occur more than once. The first episode is called an acute demyelinating attack. Fifteen to forty-five percent of children with their first...
Source: PediatricEducation.org - April 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Concentration Dependent Inhibitory Effect of a Nucleoside-based Analog Against Human Herpesvirus-6 Replication (P6.304)
Human herpesvirus-6 (HHV-6) is associated with a number neurological disorders including multiple sclerosis (MS). To test the hypothesis of HHV-6 association in MS, certain approved human herpesvirus therapies have been investigated for treatment against HHV-6 in MS patients. However, antiviral therapies specific for HHV-6 do not exist. Therefore, antivirals that primarily targert other β-herpesviruses such as human cytomegalovirus (HCMV) are often used in these trials but with minimal efficacy. Recently, a subset of nucleoside-based analogs was reported with improved efficacy against herpesviruses. Therefore, our goa...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lee, N., Leibovitch, E., Jacobson, S. Tags: HTLV and Other Viral Infections Source Type: research