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Angioinvasive Aspergillus-associated Stroke in an Immunocompetent Host Following Cardiac Surgery and ECMO
Conclusions: Ischemic infarcts in the setting of CABG or ECMO are often presumed to be thromboembolic from the heart or device, related to underlying hemodynamic instability, or due to a clinically apparent systemic infection such as endocarditis. This report suggests that invasive cerebral aspergillosis should be considered in seemingly immunocompetent patients following CABG or ECMO. The mechanism is unclear, but may be related to systemic inflammatory dysregulation resulting in increased susceptibility to uncommon pathogens.
Source: The Neurologist - May 1, 2017 Category: Neurology Tags: Case Report/Case Series Source Type: research

Aspergillus arteritis of the right internal carotid artery resulting in massive stroke
Debajyoti Chatterjee, Bishan D Radotra, Kanchan K MukherjeeNeurology India 2016 64(5):1089-1091
Source: Neurology India - September 11, 2016 Category: Neurology Authors: Debajyoti Chatterjee Bishan D Radotra Kanchan K Mukherjee Source Type: research

Fungal Infections of the Central Nervous System
This article summarizes current knowledge on the epidemiology, clinical presentations, diagnosis, and management of selected fungal infections of the central nervous system (CNS). Key syndromes, differential diagnoses, and therapeutic interventions according to host immune status and exposure are reviewed. Recent Findings:: Advancements in imaging of the brain and spinal cord, and molecular DNA and antigen-based laboratory diagnostics afford improved sensitivity for CNS mycoses. Newer therapeutic strategies may improve outcomes if provided early and host immunosuppression is abrogated. Adjunctive corticosteroid use for dis...
Source: CONTINUUM - December 1, 2015 Category: Neurology Tags: Review Articles Source Type: research

Isolated Cerebral Mucormycosis: A Case Report (P5.022)
CONCLUSION: Isolated cerebral mucormycosis is a rare and fatal condition. It is should be considered in immunocompromised patients with persistent fever not responding to antibiotics, rapidly evolving focal neurologic deficits. High index of clinical suspicion and aggressive medical management with anti-fungal therapy may result in better outcomes.Disclosure: Dr. Dhakar has nothing to disclose. Dr. Rayes has nothing to disclose. Dr. Williams has nothing to disclose. Dr. Tselis has recieved research support from Teva Neuroscience and Biogenic Idec. Dr. Norris has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dhakar, M., Rayes, M., Williams, K., Tselis, A., Norris, G. Tags: General Neurology IV Source Type: research