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Total 93 results found since Jan 2013.

Real-world analysis of a Biolimus A9 polymer-free drug-coated stent with very short dual antiplatelet therapy in patients at high bleeding risk.
CONCLUSION: In real-world patients at high risk of bleeding, implantation of the polymer-free metallic stent coated with Biolimus-A9 (Biofreedom®; Biosensors Europe, Morges, Switzerland) followed by 1 -month DAPT showed encouraging results without any stent thrombosis. PMID: 31965195 [PubMed - as supplied by publisher]
Source: Herz - January 24, 2020 Category: Cardiology Tags: Herz Source Type: research

Evidence-based reduction of cardiovascular risk in patients with diabetes.
Authors: Schütt KA Abstract Patients with type 2 diabetes mellitus exhibit a markedly increased propensity to develop cardiovascular diseases, such as myocardial infarction, stroke and heart failure. The results from large cardiovascular outcome trials conducted in recent years with novel hypoglycemic agents, such as dipeptidyl peptidase 4 (DPP-4) inhibitors, sodium-glucose transporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists have led to novel therapeutic strategies to reduce the cardiovascular risk in patients with diabetes. This overview article summarizes the evidence derived ...
Source: Herz - December 12, 2019 Category: Cardiology Tags: Herz Source Type: research

Effect of new oral anticoagulants on platelet indices in non-valvular atrial fibrillation patients.
Authors: Duzen IV, Oguz E, Cekici Y, Yavuz F, Vuruskan E, Sincer I, Poyraz F, Alıcı H, Yuksek U, Demirtas AO, Sucu M Abstract New-generation oral anticoagulants (NOACs) are now preferred as a first-line treatment in the management of atrial fibrillation for prevention of thromboembolic complications. Mean platelet volume (MPV), one of the indicators of increased platelet activity, is also associated with an increased stroke risk in atrial fibrillation patients. The aim of this study was to evaluate changes in MPV, platelet distribution width (PDW) and plateletcrit following use of NOACs. The study included 116 ...
Source: Herz - August 17, 2019 Category: Cardiology Tags: Herz Source Type: research

Pulmonary and cardiac drugs: clinically relevant interactions.
Authors: Olschewski H, Canepa M, Kovacs G Abstract Chronic heart and lung diseases are very common in the elderly population. The combination of chronic heart failure and chronic obstructive pulmonary disease (COPD) is also common and, according to current guidelines, these patients should be treated for both diseases. In patients with heart failure, beta-blockers are very important drugs because their use is associated with significantly improved morbidity and mortality. These beneficial effects were documented in patients with and without COPD, although theoretically there is a risk for bronchoconstriction, parti...
Source: Herz - July 14, 2019 Category: Cardiology Tags: Herz Source Type: research

Left heart function in COPD : Impact of lung deflation.
Authors: Struß N, Bauersachs J, Welte T, Hohlfeld JM Abstract Chronic obstructive pulmonary disease (COPD) primarily affects the lungs; however, cardiovascular conditions are among the most common extrapulmonary comorbidities. Besides shared risk factors such as cigarette smoking, pathophysiological connections between the lung and the heart have been identified as mediators of reduced cardiac output. Recent research has focused on hyperinflation of the lung as a pulmonary cause for heart dysfunction. Hyperinflation is a typical lung abnormality seen in COPD; it is characterized by increased residual volume, int...
Source: Herz - June 14, 2019 Category: Cardiology Tags: Herz Source Type: research

Erratum to: Stroke in patients with prosthetic valve endocarditis : Single-center cohort study in China.
Authors: Cao GF, Liu W, Cao L, Wang Y Abstract Erratum to: Herz 2019 https://doi.org/10.1007/s00059-019-4809-4 The original article has been corrected. The data given in Table 4 for patient No. 13 were wrong. Please find here the corrected Table.The authors and publisher apologize for this …. PMID: 31139843 [PubMed - as supplied by publisher]
Source: Herz - May 31, 2019 Category: Cardiology Tags: Herz Source Type: research

Right ventricular function in  pulmonary (arterial) hypertension.
Right ventricular function in pulmonary (arterial) hypertension. Herz. 2019 May 17;: Authors: Tello K, Gall H, Richter M, Ghofrani A, Schermuly R Abstract The right ventricle (RV) is the main determinant of prognosis in pulmonary hypertension. Adaptation and maladaptation of the RV are of crucial importance. In the course of disease, RV contractility increases through changes in muscle properties and muscle hypertrophy. At a certain point, the point of "uncoupling," the afterload exceeds contractility, and maladaptation as well as dilation occurs to maintain stroke volume (SV). To understand the adap...
Source: Herz - May 19, 2019 Category: Cardiology Tags: Herz Source Type: research

Oral anticoagulation and antiplatelet therapy in patients with atrial fibrillation after coronary interventions.
This article reviews the current data from studies testing strategies with NOACs plus one or two antiplatelet substances in comparison to triple therapy with VKA. PMID: 31087108 [PubMed - as supplied by publisher]
Source: Herz - May 16, 2019 Category: Cardiology Tags: Herz Source Type: research

Left atrial appendage closure in non-valvular atrial fibrillation.
Authors: Häusler KG, Landmesser U Abstract Atrial fibrillation is the most frequent cardiac arrhythmia worldwide, causing approximately 20% of all ischemic strokes. Therefore, oral anticoagulation is recommended in patients with atrial fibrillation with at least a moderate risk of stroke; however, there is a significant proportion of patients who cannot undergo long-term oral anticoagulation. As the left atrial appendage is of major relevance for atrial fibrillation-induced thrombus formation, catheter-based or surgical closure of the left atrial appendage appears to be a promising therapeutic option. Large regi...
Source: Herz - May 12, 2019 Category: Cardiology Tags: Herz Source Type: research

Stroke in patients with prosthetic valve endocarditis : Single-center cohort study in China.
CONCLUSION: Stroke is a common complication in PVE that increases patient mortality. Rheumatic heart disease, double valve replacement, and fungal infection may be risk factors for patients with PVE complicated by stroke. PMID: 31076822 [PubMed - as supplied by publisher]
Source: Herz - May 12, 2019 Category: Cardiology Tags: Herz Source Type: research

Embolic stroke of undetermined source (ESUS) : How much monitoring is necessary?
Authors: Stegmann T, Wachter R, Schäbitz WR Abstract The clinical construct of embolic stroke of unknown source (ESUS) was first described in 2014. It is defined as cryptogenic ischemic stroke after the exclusion of a lacunar infarct, a significant (≥50%) stenosis of extracranial or intracranial arteries and a cardiac source of embolism. Initially, there was hope that these patients would benefit from anticoagulation. This was based on the suspicion that imaging criteria of stroke mimic features of embolism from cardiac sources or the great arteries. In two large randomized trials with 12,600 patients neither ri...
Source: Herz - May 9, 2019 Category: Cardiology Tags: Herz Source Type: research

Heart and brain-two terms, one central problem : The stroke.
Authors: Erbel R, Diener HC PMID: 31041491 [PubMed - as supplied by publisher]
Source: Herz - May 2, 2019 Category: Cardiology Tags: Herz Source Type: research

Cardiac imaging after ischemic stroke : Echocardiography, CT, or MRI?
Authors: Camen S, Haeusler KG, Schnabel RB Abstract About 20-25% of all ischemic strokes are of cardioembolic etiology, with atrial fibrillation and heart failure as the most common underlying pathologies. Diagnostic work-up by noninvasive cardiac imaging is essential since it may lead to changes in therapy, e.g., in-but not exclusively-secondary stroke prevention. Echocardiography remains the cornerstone of cardiac imaging after ischemic stroke, with the combination of transthoracic and transesophageal echocardiography as gold standard thanks to their high sensitivity for many common pathologies. Transesophageal e...
Source: Herz - April 5, 2019 Category: Cardiology Tags: Herz Source Type: research

Closure of the patent foramen ovale (PFO) in cryptogenic stroke.
Authors: Diener HC, Knebel F Abstract Autopsy studies and echocardiographic investigations have shown that around 20-25% of the healthy population have a patent foramen ovale (PFO). In patients younger than 55 years the risk of a cryptogenic stroke is increased in the presence of a PFO. The first three randomized studies could not demonstrate superiority of an interventional closure of a PFO compared to antithrombotic treatment in patients with cryptogenic stroke. The results of three recently published studies and the extension of an earlier study showed a superiority of an interventional closure of a PFO comp...
Source: Herz - April 5, 2019 Category: Cardiology Tags: Herz Source Type: research

Clinical implications of cardiovascular outcome trials in type  2 diabetes.
Clinical implications of cardiovascular outcome trials in type 2 diabetes. Herz. 2019 Feb 25;: Authors: Mellbin LG, Wang A, Rydén L Abstract Cardiovascular disease (CVD) is the main reason for premature death in patients with type 2 diabetes. Hyperglycemia, the hallmark of diabetes, has long been considered the link between diabetes and CVD, and many trials focused on preventing CVD manifestations by means of tight glucose control. However, diabetes is a multifactorial disease in which, e. g., insulin resistance, endothelial dysfunction, and factors such as hypertension and dyslipidemia contrib...
Source: Herz - February 27, 2019 Category: Cardiology Tags: Herz Source Type: research