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Short-term lithium treatment protects the brain against ischemia-reperfusion injury by enhancing the neuroplasticity of cortical neurons
CONCLUSION: Our study confirmed that neuroplasticity in cortical neurons is crucial for lithium-induced brain function 50 recovery after brain ischemia.PMID:34396932 | DOI:10.1080/01616412.2021.1965427
Source: Neurological Research - August 16, 2021 Category: Neurology Authors: Shih-Huang Tai Liang-Chun Chao Tung-Yi Huang Che-Chao Chang Sheng-Yang Huang Tian-Shung Wu E-Jian Lee Source Type: research

Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period
CONCLUSION: Lithium upregulates BDNF, GAP-43, and PSD-95, which partly accounts for its improvement of neuroplasticity and provision of long-term neuroprotection in the ischemic brain.Abbreviations: BDNF: brain-derived neurotrophic factor; ECM: extracellular matrix; EDTA: ethylenediaminetetraacetic acid; GAP-43: growth-associated protein-43; GSK-3β: glycogen synthase kinase-3β; HBSS: Hank's balanced salt solution; LCBF: local cortical blood perfusion; LDF: laser-Doppler flowmetry; MCAO: middle cerebral artery occlusion; MMP: matrix metalloproteinase; NMDA: N-methyl-D-aspartate; NMDAR: N-methyl-D-aspartate receptor; OCT: ...
Source: Neurological Research - March 29, 2022 Category: Neurology Authors: Shih-Huang Tai Sheng-Yang Huang Liang-Chun Chao Yu-Wen Lin Chien-Chih Huang Tian-Shung Wu Yan-Shen Shan Ai-Hua Lee E-Jian Lee Source Type: research