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Prevalence and factors influencing the occurrence of spasticity in stroke patients: a retrospective study
CONCLUSION: Most stroke patients do not have spasticity, especially the elderly, patients with ischemic stroke, and those with mild functional impairment, suggesting that not all upper motor nerve injuries lead to increased muscle tension. For young individuals, patients with hemorrhagic stroke, and those with moderate to severe functional impairment, close follow-up is necessary to identify the occurrence of spasticity early on and then formulate corresponding rehabilitation strategies for prompt intervention.PMID:36153827 | DOI:10.1080/01616412.2022.2127249
Source: Neurological Research - September 25, 2022 Category: Neurology Authors: Huan Cheng Xiangqin Fang Lingyi Liao Yong Tao Changyue Gao Source Type: research

Preexisting dual antiplatelet treatment increases the risk of post-thrombolysis intracranial hemorrhage in Chinese stroke patients.
DISCUSSION: The risk of developing sICH is low when thrombolysis is given to patients who are on ASA alone. However, there is potential increased risk of sICH if a patient is on dual AP treatment. PMID: 24861494 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis.
Authors: Kumar A, Sharma R, Misra S, Nath M, Kumar P Abstract Studies on relationship between methylenetetrahydrofolate reductase gene (MTHFR) gene A1298C polymorphism with the risk of ischemic as well as hemorrhagic stroke have shown discordant results. Present meta-analysis was aimed to clarify the relationship between MTHFR gene A1298C polymorphism with risk of stroke. A comprehensive literature search for all published articles was performed in electronic database including PubMed, EMbase, Cochrane Library, Trip Databases, Worldwide Science, CINAHL, and Google Scholar up to 31st  December 2019. Pooled odds r...
Source: Neurological Research - August 1, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Association of inflammatory and platelet volume markers with clinical outcome in patients with anterior circulation ischaemic stroke after endovascular thrombectomy.
Conclusions: MPV, PDW, and MPV/PC are associated with stroke severity. Higher NLR levels upon admission may predict unfavorable functional outcomes in patients with AIS after undergoing EVT.Abbreviations ACA: anterior cerebral artery; AIS: acute ischemic stroke; ASPECTS: alberta stroke program early CT score; BMI: body mass index; DBP: diastolic blood pressure; END: early neurological deterioration; EVT: endovascular thrombectomy; hs-CRP: high-sensitivity C-reactive protein; HT: hemorrhagic transformation; ICA: internal carotid artery; IL-6: interleukin-6; IS: ischemic progression; LAA: Large-Artery Atherosclerosis; MCA: m...
Source: Neurological Research - January 8, 2021 Category: Neurology Tags: Neurol Res Source Type: research

The effect of robot-assisted walking in different modalities on cardiorespiratory responses and energy consumption in patients with subacute stroke
DISCUSSION: By decreasing GF and BWS values during robot-assisted walking, adequate cardio-metabolic and energy response in both subacute stroke patients and healthy individuals could be achieved. These results show us that it is important to consider the cardiorespiratory function of the patient when choosing training protocols.PMID:36884354 | DOI:10.1080/01616412.2023.2188520
Source: Neurological Research - March 8, 2023 Category: Neurology Authors: Ahmet Mert Say ın Neslihan Duruturk Birol Balaban S üleyman Korkusuz Source Type: research

Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds.
CONCLUSIONS: For the treatment of high-risk TIA or minor stroke patients, the clopidogrel-aspirin treatment did not increase the number of CMB than Aspirin alone. It appears that the extent of CMB was associated with the extent of existing CMB occurred in previous stroke, which was mostly located in cortical, subcortical zone. PMID: 26391570 [PubMed - in process]
Source: Neurological Research - September 25, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Frequency and risk factors of spontaneous hemorrhagic transformation following ischemic stroke on the initial brain CT or MRI: data from the China National Stroke Registry (CNSR).
DISCUSSION: Spontaneous HT occurred in 0.92% of the patients with IS in the acute stage. Being female, excess alcohol consumption, atrial fibrillation, and a prolonged period between IS onset and initial imaging were associated with an increased risk of spontaneous HT. PMID: 27320249 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

AST to ALT ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke.
CONCLUSIONS: Higher AAR was associated with an increased risk of HT after ischemic stroke. In addition, AAR might be a better biomarker for predicting HT than ALT or AST. PMID: 32697140 [PubMed - as supplied by publisher]
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Argatroban plus aspirin versus aspirin in acute ischemic stroke.
CONCLUSION: Argatroban is effective and safe for the treatment of moderate AIS with similar efficacy to high-dose aspirin in the acute phase of AIS, although no additional benefit on short-term outcome was observed. For patients with mild AIS, argatroban may be inferior to high-dose aspirin. PMID: 30052164 [PubMed - as supplied by publisher]
Source: Neurological Research - July 30, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Predictors of mortality and recurrent stroke within five years of intracerebral hemorrhage.
Conclusion Predictors of recurrent stroke were older females, hypertension, diabetes, and brain stem hemorrhage. These findings may help to determine specific treatment strategies and improve quality of health care for such patients. PMID: 30134784 [PubMed - in process]
Source: Neurological Research - August 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
CONCLUSION: Pathogenesis of AF is involved abnormal changes of hemostasis, endothelial dysfunction, antithrombotic state and inflammation. The homeostatic markers, which play role in these pathways, and the presence of BMBs could use to form a prognostic clinic assessment tool to predict bleeding risk. PMID: 30207930 [PubMed - as supplied by publisher]
Source: Neurological Research - September 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between the platelet to leukocyte ratio and mechanical thrombectomy outcomes in acute ischemic stroke patients.
CONCLUSION: Platelet to leukocyte ratio may be use to assess the risk of functional outcome and sICH in patients with acute anterior circulation occlusion stroke undergoing endovascular treatment in real world China. PMID: 32643590 [PubMed - as supplied by publisher]
Source: Neurological Research - July 11, 2020 Category: Neurology Tags: Neurol Res Source Type: research

C-Reaction Protein and the Severity of Intracerebral Hemorrhage: A Study from Chinese Stroke Center Alliance
CONCLUSIONS: High CRP level was independently associated with poorer clinical outcome and higher in-hospital death in patients with ICH.PMID:34559025 | DOI:10.1080/01616412.2021.1980842
Source: Neurological Research - September 24, 2021 Category: Neurology Authors: Dandan Wang Jing Wang Zixiao Li Hongqiu Gu Kaixuan Yang Xingquan Zhao Yongjun Wang Source Type: research

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