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Correlation between cerebral blood volume values and outcomes in endovascular therapy for acute ischemic stroke
Conclusions We found that cortical CBV loss is predictive of poor clinical outcomes, whereas basal ganglia CBV loss is predictive of hemorrhagic transformation but without translation into poor clinical outcomes. Our study findings support published results of baseline preintervention CBV as a predictor of outcomes in patients undergoing intra-arterial stroke therapies.
Source: Journal of NeuroInterventional Surgery - September 13, 2015 Category: Neurosurgery Authors: Mokin, M., Morr, S., Fanous, A. A., Shallwani, H., Natarajan, S. K., Levy, E. I., Snyder, K. V., Siddiqui, A. H. Tags: Ischemic stroke Source Type: research

Outcomes after endovascular treatment for anterior circulation stroke presenting as wake-up strokes are not different than those with witnessed onset beyond 8 hours
Conclusions Rates of good outcomes, parenchymal hematoma, and final infarct volumes following endovascular treatment may not be different in patients with WUS compared with patients with witnessed onset of symptoms beyond 8 h.
Source: Journal of NeuroInterventional Surgery - November 13, 2015 Category: Neurosurgery Authors: Aghaebrahim, A., Leiva-Salinas, C., Jadhav, A. P., Jankowitz, B., Zaidi, S., Jumaa, M., Urra, X., Amorim, E., Zhu, G., Giurgiutiu, D.-V., Horev, A., Reddy, V., Hammer, M., Wechsler, L., Wintermark, M., Jovin, T. Tags: Ischemic stroke Source Type: research

Collateral flow as causative of good outcomes in endovascular stroke therapy
Conclusions Improved collateral flow in patients with AIS undergoing endovascular therapy was associated with improved radiographic and clinical outcomes. Independent of age, vessel occlusion and time, in patients with comparable ischemic burdens, changes in collateral grade alone led to significant differences in initial stroke severity as well as ultimate clinical outcome.
Source: Journal of NeuroInterventional Surgery - December 13, 2015 Category: Neurosurgery Authors: Sheth, S. A., Sanossian, N., Hao, Q., Starkman, S., Ali, L. K., Kim, D., Gonzalez, N. R., Tateshima, S., Jahan, R., Duckwiler, G. R., Saver, J. L., Vinuela, F., Liebeskind, D. S., for the UCLA Collateral Investigators Tags: Ischemic stroke Source Type: research

Operator assessment versus core laboratory adjudication of recanalization following endovascular treatment of acute ischemic stroke: a systematic review and meta-analysis
Conclusion Operator angiographic reads are statistically significantly higher than core laboratory-read readings following stroke thrombectomy, especially for complete recanalization. These differences should be considered when interpreting reports of angiographic outcomes after thrombectomy.
Source: Journal of NeuroInterventional Surgery - January 11, 2023 Category: Neurosurgery Authors: Ibrahim, M. K., Shehata, M. A., Ghozy, S., Bilgin, C., Jabal, M. S., Heiferman, D. M., Kadirvel, R., Kallmes, D. F. Tags: Ischemic stroke Source Type: research

E-036 age, stroke severity, use of stent retrievers, general anesthesia, and hemorrhagic conversion may predict outcome in stroke patients who undergo successful intra-arterial therapy
ConclusionAge, NIHSS score, use of stent retrievers, mode of anesthesia, and symptomatic ICH might affect functional outcome in stroke patients who achieve successful recanalization via intra-arterial therapy. Prospective studies, or a meta-analysis of sub-groups in the recently published prospective trials are needed to confirm the association between those factors, or others, and functional outcome. Identification of such predictors might help in screening acute stroke patients for intra-arterial therapy.DisclosuresM. Noufal: None. J. Mankad: None. D. Shirilla: None. A. Lakraj: None. J. Cox: None. A. Sattar: None. W. Wal...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Noufal, M., Mankad, J., Shirilla, D., Lakraj, A., Cox, J., Sattar, A., Wally, W., Sallowm, Y., Lynch, J., Zaidat, O. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

E-074 Predictors of hemorrhagic conversion following mechanical thrombectomy for acute ischemic stroke (AIS)
ConclusionHistory of prior stroke, radiographic evidence of infarct burden, and radiographic success of thrombectomy may be considered significant predictors for hemorrhagic conversion following AIS in patients who undergo mechanical thrombectomy.Disclosures A. Boyke: None. K. Javed: None. J. Dardick: None. I. Naidu: None. J. Ryvlin: None. D. Kadaba: None. N. Haranhalli: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Boyke, A., Javed, K., Dardick, J., Naidu, I., Ryvlin, J., Kadaba, D., Haranhalli, N. Tags: Electronic poster abstracts Source Type: research

O-016 Outcomes after endovascular mechanical thrombectomy for low national institutes of health stroke scale (NIHSS): a multicenter study
ConclusionsMT is an effective and safe treatment for appropriately selected ischemic stroke patients presenting with low NIHSS. Diabetes and prior stroke are predictors of functional dependence at 90 days, and prior stroke is also associated with mortality, suggesting that MT should be offered judiciously to patients with these risk factors. Our findings signal the need for a randomized trial comparing MT versus medical management for LVO patients with low NIHSS.Disclosures I. Abecassis: 2; C; IschemaView (Rapid), Remedy Robotics. E. Almallouhi: None. R. Chalhoub: None. S. Kassab: None. E. Bass: None. D. Ding: None. I. Mai...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Abecassis, I., Almallouhi, E., Chalhoub, R., Kassab, S., Bass, E., Ding, D., Maier, I., Psychogios, M., Liman, J., Alawieh, A., Wolfe, S., Arthur, A., Kan, P., Kim, J., De Leacy, R., Osbun, J., Jabbour, P., Grossbereg, J., Park, M., Mascitelli, J., Levitt Tags: SNIS 19th annual meeting oral abstracts Source Type: research

E-189 Outcomes of tenecteplase versus alteplase after mechanical thrombectomy in a multiethnic stroke consortium registry
ConclusionIn this prospective, multi-center stroke consortium study, IV TNK in comparison to tPA prior to MT for ischemic stroke resulted in non-inferior outcomes related to angiographic reperfusion and functional status at discharge. These findings compliment the current literature and include a large Hispanic US cohort. Further analysis will include expansion of contributing centers and use of propensity scoring.Abstract E-189 Table 1 and 2Disclosures M. Gaub: None. D. Ramaswamy: None. A. Cardentey: None. S. Bandela: None. G. Gealogo: None. J. Mascitelli: None. F. Al Saiegh: None. L. Birnbaum: 2; C; Rapid AI, Imperative Care.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Gaub, M., Ramaswamy, D., Cardentey, A., Bandela, S., Gealogo, G., Mascitelli, J., Al Saiegh, F., Birnbaum, L. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-229 Mechanical thrombectomy in low alberta stroke program early CT score (ASPECTS) in hyperacute stroke - a systematic review and meta-analysis
ConclusionMT in hyperacute stroke patients with low ASPECTS (≤5) may result in ambulatory clinical outcomes with acceptable hemorrhage risk. Although a high proportion of patients achieved successful recanalization, this benefit did not fully translate to better clinical outcomes.Abstract E-229 Figure 1Disclosures A. Baig: None. M. Bouslama: None. R. Turner: None. A. Aguirre: None. C. Kuo: None. J. Lim: None. B. Donnelly: None. P. Lai: None. K. Raygor: None. E. Levy: 2; C; Claret Medical, GLG Consulting, Guidepoint Global, Imperial Care, Medtronic, Rebound, StimMed, Misionix, Mosiac, and others. 4; C; NeXtGen Biologics,...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Baig, A., Bouslama, M., Turner, R., Aguirre, A., Kuo, C., Lim, J., Donnelly, B., Lai, P., Raygor, K., Levy, E., Siddiqui, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-008 Clinical and Radiographic Outcome of Acute Ischemic Stroke Patient who Presented with Middle Cerebral Artery Occlusion-A Single Center Experience
Conclusions Solitaire retrieval device achieves a very high rate of recanalazitation in acute ischemic stroke with MCA occlusion and results in a good clinical outcome. However, a considerable valuable time is still lost from ER arrival to IR arrival. Patients who required endotracheal intubation at presentation and or had NIHSS 20 or higher are associated with poor outcome despite TICI3 recanalization. Further studied are required. Disclosures Y. Lodi: None. V. Reddy: None. A. Devasenapathy: None. J. Chou: None. K. Shehades: None. K. Sethi: None. D. Galyon: None. S. Bajwa: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Lodi, Y., Reddy, V., Devasenapathy, A., Chou, J., Shehades, K., Sethi, K., Galyon, D., Bajwa, S. Tags: Electronic poster abstracts Source Type: research

E-084 proximal versus distal occlusions in the posterior circulation: acute stroke etiology in endovascular therapy
ConclusionsWhile clinically devastating, posterior circulation stroke, may have favorable outcomes if endovascular strategies are targeted to arterial occlusion etiology.DisclosuresM. Nour: None. S. Tateshima: 2; C; Reverse Medical, Stryker Neurovascular, Silkroad Medical, Blockade Medical. G. Duckwiler: 2; C; Sequent Medical, Asahi Medical. R. Jahan: 2; C; Covidien, Medina. N. Gonzalez: None. V. Szeder: None. L. Ai: None. J. Saver: 6; C; Dr. Saver is an employee of the University of California. The University of California, Regents receive funding for Dr. Saver’s services as a scientific consultant. D. Liebeskind: 2...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Nour, M., Tateshima, S., Duckwiler, G., Jahan, R., Gonzalez, N., Szeder, V., Ai, L., Saver, J., Liebeskind, D. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

E-096 COVID status is related to clot burden during thrombectomy in acute stroke patients
ConclusionOf 230 patients included in this interim analysis across 24 centers in the United States, between 02/2021 and 01/2022, 16 patients had a history of COVID. Comparing COVID-positive to non-positive, patients with COVID were younger (median 66.5 years vs 71.5 years, p 0.042), and had more intracranial clot by weight (median 101.0 mg vs 42.0 mg, p 0.047). There was a trend toward COVID positive patients to have more clot volume (median 180 cc vs 77.5 cc p 0.08), suggesting the difference was a higher clot burden instead of more density to the thrombus. These results suggest different histopathological characteristics...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fraser, J., Dabney, A., Vicari, J., Rivet, D., Woodward, B., Nanda, A., Fiorella, D., Baltan, S., Sohrabji, F., Pennypacker, K., Kellner, C. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Association of clot burden score with radiographic and clinical outcomes following Solitaire stent retriever thrombectomy: analysis of the SWIFT PRIME trial
Conclusions The combination of IV thrombolysis and stent retriever thrombectomy with the Solitaire device is highly effective in achieving successful recanalization and a good clinical outcome throughout the entire range of CBS values.
Source: Journal of NeuroInterventional Surgery - September 12, 2017 Category: Neurosurgery Authors: Mokin, M., Levy, E. I., Siddiqui, A. H., Goyal, M., Nogueira, R. G., Yavagal, D. R., M Pereira, V., Saver, J. L. Tags: Ischemic stroke Source Type: research

LB-005 The INSIGHT registry: a multi-center, multi-omic stroke clot study, preliminary results
ConclusionThese preliminary results demonstrate the real-world applicability of the INSIGHT study to typical stroke thrombectomy population. Furthermore, the tissue processing protocols are providing high-quality RNA and protein for analysis, which is currently underway.DisclosuresJ. Fraser: 1; C; Penumbra, University of Kentucky. 2; C; Stream Biomedical, Medtronic. 4; C; Cerelux, Fawkes Biotechnology. J. Vicari: None. A. Nanda: None. E. Cheng-Ching: None. K. Woodward: None. B. Rapoport: None. C. Kellner: None.
Source: Journal of NeuroInterventional Surgery - July 29, 2021 Category: Neurosurgery Authors: Fraser, J., Vicari, J., Nanda, A., Cheng-Ching, E., Woodward, K., Rapoport, B., Kellner, C. Tags: Late-breaking oral abstracts Source Type: research

Clinical, angiographic and radiographic outcome differences among mechanical thrombectomy devices: initial experience of a large-volume center
Conclusions Although our initial data confirm the superiority of SR technology over the Merci device, there was no significant difference in near complete/complete reperfusion, final infarct volumes or clinical outcomes between SR and Penumbra thromboaspiration.
Source: Journal of NeuroInterventional Surgery - February 12, 2015 Category: Neurosurgery Authors: Kass-Hout, T., Kass-Hout, O., Sun, C.-H. J., Kass-Hout, T., Belagaje, S., Anderson, A., Frankel, M., Gupta, R., Nogueira, R. Tags: Ischemic stroke Source Type: research

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