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Differential effect of mechanical thrombectomy and intravenous thrombolysis in atrial fibrillation associated stroke
Conclusions In patients treated with MT, comorbid AF is associated with faster procedural time, fewer passes, and increased rates of first pass success without increased risk of intracranial hemorrhage or worse functional outcomes. These results are in contrast to the increased hemorrhage rates and worse functional outcomes observed in AF associated stroke treated with supportive care and or IVT. These data suggest that MT negates the AF penalty in ischemic stroke.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Akbik, F., Alawieh, A., Cawley, C. M., Howard, B. M., Tong, F. C., Nahab, F., Saad, H., Dimisko, L., Mustroph, C., Samuels, O. B., Pradilla, G., Maier, I., Goyal, N., Starke, R. M., Rai, A., Fargen, K. M., Psychogios, M. N., Jabbour, P., De Leacy, R., Gil Tags: Ischemic stroke Source Type: research

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke
Conclusions An assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.
Source: Journal of NeuroInterventional Surgery - August 13, 2021 Category: Neurosurgery Authors: Itsekson Hayosh, Z., Abu Bandora, E., Shelestovich, N., Nulman, M., Bakon, M., Yaniv, G., Khaitovitch, B., Balan, S., Gerasimova, A., Drori, T., Mausbach, S., Schwammenthal, Y., Afek, A., Chapman, J., Shavit Stein, E., Orion, D. Tags: Ischemic stroke Source Type: research

Analysis of microRNA signatures in ischemic stroke thrombus
Conclusions The microRNA expression pattern can provide information regarding the mechanism of stroke by reflecting the underlying pathological status of the organ from which the thrombus was derived.
Source: Journal of NeuroInterventional Surgery - April 12, 2022 Category: Neurosurgery Authors: Kim, J.-M., Byun, J.-S., Kim, J., Park, M.-S., Hong, S. A., Nam, T.-K., Choi, H. H., Hong, S., Han, S.-H., Jeong, H.-B., Park, K.-Y., Kim, H. R. Tags: Ischemic stroke Source Type: research

Predictors of futile recanalization after endovascular treatment in acute ischemic stroke: a meta-analysis
Conclusion This study identified female sex, comorbidities, admission systolic blood pressure, serum glucose, occlusion site, non-bridging therapy, and post-procedural complication as predictors of futile recanalization, and also confirmed previously reported factors. Further large-scale prospective studies are needed.
Source: Journal of NeuroInterventional Surgery - August 12, 2022 Category: Neurosurgery Authors: Deng, G., Xiao, J., Yu, H., Chen, M., Shang, K., Qin, C., Tian, D.-S. Tags: Ischemic stroke Source Type: research

Early arrival at the emergency department is associated with better collaterals, smaller established infarcts and better clinical outcomes with endovascular stroke therapy: SWIFT study
Conclusions Time was a critical factor in successful clinical outcomes for neurothrombectomy in the SWIFT trial. Shorter times to presentation were associated with better collaterals, smaller established infarcts, and better clinical outcome after revascularization.
Source: Journal of NeuroInterventional Surgery - May 12, 2016 Category: Neurosurgery Authors: Liebeskind, D. S., Jahan, R., Nogueira, R. G., Jovin, T. G., Lutsep, H. L., Saver, J. L., for the SWIFT Investigators Tags: Editor''s choice, Ischemic stroke Source Type: research

Factors associated with successful revascularization using the aspiration component of ADAPT in the treatment of acute ischemic stroke
Conclusions Aspiration success was associated with younger age. Our findings suggest that ADAPT can be used for the vast majority of patients but it may be beneficial to use a different method first in the elderly.
Source: Journal of NeuroInterventional Surgery - June 16, 2017 Category: Neurosurgery Authors: Mascitelli, J. R., Kellner, C. P., Oravec, C. S., De Leacy, R. A., Oermann, E. K., Yaeger, K., Paramasivam, S., Fifi, J. T., Mocco, J. Tags: Ischemic stroke Source Type: research

Bridging thrombolysis in atrial fibrillation stroke is associated with increased hemorrhagic complications without improved outcomes
Conclusion In this large thrombectomy registry, AF patients exposed to IVT before MT had increased hemorrhagic complications without improved functional outcomes, in contrast with non-AF patients. Prospective trials are warranted to assess whether AF patients represent a subgroup of LVO patients who may benefit from a direct to thrombectomy approach at thrombectomy capable centers.
Source: Journal of NeuroInterventional Surgery - September 14, 2022 Category: Neurosurgery Authors: Akbik, F., Alawieh, A., Dimisko, L., Howard, B. M., Cawley, C. M., Tong, F. C., Nahab, F., Samuels, O. B., Maier, I., Feng, W., Goyal, N., Starke, R. M., Rai, A., Fargen, K. M., Psychogios, M. N., Jabbour, P., De Leacy, R., Keyrouz, S. G., Dumont, T. M., Tags: Ischemic stroke Source Type: research

Relative CBV ratio on perfusion-weighted MRI indicates the probability of early recanalization after IV t-PA administration for acute ischemic stroke
Conclusions The results of this study suggest that the rCBV ratio on PWI might serve as a useful indicator of ER after IV t-PA administration.
Source: Journal of NeuroInterventional Surgery - February 14, 2016 Category: Neurosurgery Authors: Sohn, S.-W., Park, H.-S., Cha, J.-K., Kim, D.-H., Kang, M.-J., Choi, J.-H., Nah, H.-W., Huh, J.-T. Tags: Ischemic stroke Source Type: research

Preprocedural determination of an occlusion pathomechanism in endovascular treatment of acute stroke: a machine learning-based decision
Conclusions An ML-PM could accurately determine an occlusion pathomechanism with common preprocedural findings. A decision flowchart consisting of the four most influential findings was clinically applicable and superior to single common preprocedural findings for determining an occlusion pathomechanism.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Baek, J.-H., Kim, B. M., Kim, D. J., Heo, J. H., Nam, H. S., Kim, Y. D., Rho, M. H., Chung, P.-W., Won, Y. S., Chung, Y. Tags: Ischemic stroke Source Type: research

P-008 Evaluating Racial/Ethnic Disparity in Endovascular Thrombectomy Outcome for Acute Stroke Patients: 4,763 patients using Premier data 2011 to 2015
ConclusionsThere were no differences in hospital outcome among races/ethnicities in endovascular thrombectomy outcomes for acute stroke patients in the Premier data. Racial/ethnic disparities play role for patients’ selection not for patients’ outcome in endovascular thrombectomy.DisclosuresS. Park: None. M. Pilot: None. M. Alexander: 1; C; Consultant for Stryker Neurovascular, Medtronic, and Penumbra, Inc. A. Rosengart: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Park, S., Pilot, M., Alexander, M., Rosengart, A. Tags: Oral poster abstracts Source Type: research

E-051 Disparities in stroke: Associating socioeconomic factors with ischemic stroke outcome
ConclusionsMedian income based on zip code is a SES indicator that is potentially associated with functional outcomes of ischemic stroke patients undergoing mechanical thrombectomy. Further studies addressing this relationship are needed.Disclosures A. Nguyen: None. G. M. Cortez: None. M. Baretta: None. A. Aghaebrahim: None. E. Sauvageau: None. R. Hanel: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Nguyen, A., Cortez, G., Baretta, M., Aghaebrahim, A., Sauvageau, E., Hanel, R. Tags: Electronic poster abstracts Source Type: research

E-086 The effect of covid-19 vaccines on stroke outcomes: a single-center study
ConclusionAlthough vaccination did not show any significant difference in stroke patient outcomes on follow-up, vaccines were associated with lower rates of morbidity and mortality at discharge among stroke patients during the pandemic.Abstract E-086 Table 1Comparison of outcomes between COVID-19-positive unvaccinated vs. fully vaccinated patients presenting with stroke.*Adjusted for hypertension, atrial fibrillation, PVD, admission NIHSS, ASPECTS, tandem occlusion, and thrombectomy Unvaccinated Vaccinated Effect Variable Unadjusted Value (95% CI ) Unadjusted p-value Adjusted Value (95% CI )* Adjusted p-value* Primary Out...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: El Naamani, K., Amllay, A., Chen, C., Capone, S., Abbas, R., Sioutas, G., Munoz, A., Yudkoff, C., Carreras, A., Samabngi, A., Hunt, A., Jain, P., Stine, E., Sathe, A., Smit, R., Yazbeck, F., Tjoumakaris, S., Gooch, M., Herial, N., Rosenwasser, R., Zarzour Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-033 The smoking-thrombolysis paradox in large vessel occlusion acute ischemic stroke after endovascular therapy
Conclusion In stroke patients treated with mechanical thrombectomy, smoking does not seem to be associated with outcomes regardless of stroke subtype or location. Disclosures J. Grossberg: None. M. Bouslama: None. L. Rebello: None. D. Haussen: None. M. Frankel: None. R. Nogueira: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Grossberg, J., Bouslama, M., Rebello, L., Haussen, D., Frankel, M., Nogueira, R. Tags: Electronic Poster Abstracts Source Type: research

O-016 Outcomes after endovascular mechanical thrombectomy for low national institutes of health stroke scale (NIHSS): a multicenter study
ConclusionsMT is an effective and safe treatment for appropriately selected ischemic stroke patients presenting with low NIHSS. Diabetes and prior stroke are predictors of functional dependence at 90 days, and prior stroke is also associated with mortality, suggesting that MT should be offered judiciously to patients with these risk factors. Our findings signal the need for a randomized trial comparing MT versus medical management for LVO patients with low NIHSS.Disclosures I. Abecassis: 2; C; IschemaView (Rapid), Remedy Robotics. E. Almallouhi: None. R. Chalhoub: None. S. Kassab: None. E. Bass: None. D. Ding: None. I. Mai...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Abecassis, I., Almallouhi, E., Chalhoub, R., Kassab, S., Bass, E., Ding, D., Maier, I., Psychogios, M., Liman, J., Alawieh, A., Wolfe, S., Arthur, A., Kan, P., Kim, J., De Leacy, R., Osbun, J., Jabbour, P., Grossbereg, J., Park, M., Mascitelli, J., Levitt Tags: SNIS 19th annual meeting oral abstracts Source Type: research

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