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Source: The Lancet Neurology
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Total 249 results found since Jan 2013.
Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Lesly A Pearce , Leslie A McClure , David C Anderson , Claudia Jacova , Mukul Sharma , Robert G Hart , Oscar R Benavente Background The primary outcome results for the SPS3 trial suggested that a lower systolic target blood pressure (<130 mm Hg) might be beneficial for reducing the risk of recurrent stroke compared with a higher target (130–149 mm Hg), but that the addition of clopidogrel to aspirin was not beneficial compared with aspirin plus placebo. In this prespecified secondary outcome analysis of the SPS3 trial, we...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke: secondary analyses from CLOTS 3, a randomised trial
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Background The results of the CLOTS 3 trial showed that intermittent pneumatic compression (IPC) reduced the risk of deep vein thrombosis and improved survival in immobile patients with stroke. IPC is now being widely used in stroke units. Here we describe the disability, living circumstances, quality of life, and hospital costs of patients in CLOTS 3. Methods In CLOTS 3, a parallel group trial in 94 UK hospitals, immobile patients with stroke from days 0 to 3 of admission were assigned with a computer-generated allocation sequence in a 1:1 r...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Jane S Paulsen , Jeffrey D Long , Christopher A Ross , Deborah L Harrington , Cheryl J Erwin , Janet K Williams , Holly James Westervelt , Hans J Johnson , Elizabeth H Aylward , Ying Zhang , H Jeremy Bockholt , Roger A Barker Background Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and pr...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study
Publication date: Available online 28 November 2014 Source:The Lancet Neurology Author(s): Johann Willeit , Theresa Geley , Johannes Schöch , Heinrich Rinner , Andreas Tür , Hans Kreuzer , Norbert Thiemann , Michael Knoflach , Thomas Toell , Raimund Pechlaner , Karin Willeit , Natalie Klingler , Silvia Praxmarer , Michael Baubin , Gertrud Beck , Klaus Berek , Christian Dengg , Klaus Engelhardt , Thomas Erlacher , Thomas Fluckinger , Wilhelm Grander , Josef Grossmann , Hermann Kathrein , Norbert Kaiser , Benjamin Matosevic , Heinrich Matzak , Markus Mayr , Robert Perfler , Werner Poewe , Alexandra Rauter , Gudrun Schoen...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Covering all the bases to improve acute stroke care
Publication date: Available online 28 November 2014 Source:The Lancet Neurology Author(s): Steven R Levine
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Neuropsychiatric outcomes after stroke
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Merja E Kallio
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Neuropsychiatric outcomes after stroke – Authors' reply
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Sebastian Köhler , Maree L Hackett , John T O'Brien , Gillian E Mead
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
Chronic kidney disease and stroke
Publication date: November 2014 Source:The Lancet Neurology, Volume 13, Issue 11 Author(s): Cheng-Yang Hsieh , Huey-Juan Lin , Chih-Hung Chen , Edward Chia-Cheng Lai , Yea-Huei Kao Yang
Source: The Lancet Neurology - October 17, 2014 Category: Neurology Source Type: research
Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial
This study is registered with ClinicalTrials.gov, number NCT00349622. Findings Stage 3 included 66 participants from stages 1 and 2 and 448 new participants. In total, 340 participants were randomly allocated to ceftriaxone and 173 to placebo. During stages 1 and 2, mean ALSFRS-R declined more slowly in participants who received 4 g ceftriaxone than in those on placebo (difference 0·51 units per month, 95% CI 0·02 to 1·00; p=0·0416), but in stage 3 functional decline between the treatment groups did not differ (0·09, −0·06 to 0·24; p=0·2370). No significant differences in survival between the groups were recorde...
Source: The Lancet Neurology - October 17, 2014 Category: Neurology Source Type: research
