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Phosphofructokinase-1 inhibition promotes neuronal differentiation of neural stem cells and functional recovery after stroke
Publication date: Available online 6 February 2021Source: NeuroscienceAuthor(s): Fengyun Zhang, Qiangming Li, Haiying Liang, Yuxia Zhang
Source: Neuroscience - February 6, 2021 Category: Neuroscience Source Type: research

Intravenous Infusion of Mesenchymal Stem Cells Improves Impaired Cognitive Function in a Cerebral Small Vessel Disease Model
Publication date: Available online 16 April 2019Source: NeuroscienceAuthor(s): Masahito Nakazaki, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Junpei Suzuki, Yuichi Sasaki, Hiroshi Nagahama, Kazuo Hashi, Jeffery D. Kocsis, Osamu HonmouAbstractCerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood–brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atr...
Source: Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia
Publication date: 1 June 2018 Source:Neuroscience, Volume 380 Author(s): Krista M. Rodgers, Jared T. Ahrendsen, Olivia P. Patsos, Frank A. Strnad, Joan C. Yonchek, Richard J. Traystman, Wendy B. Macklin, Paco S. Herson Replacement of dead neurons following ischemia, either via enhanced endogenous neurogenesis or stem cell therapy, has long been sought. Unfortunately, while various therapies that enhance neurogenesis or stem cell therapies have proven beneficial in animal models, they have all uniformly failed to truly replace dead neurons in the ischemic core to facilitate long-term recovery. Remarkably, we observe robust...
Source: Neuroscience - April 17, 2018 Category: Neuroscience Source Type: research

Enhanced angiogenesis promoted by human umbilical mesenchymal stem cell transplantation in stroked mouse is Notch1 signaling associated
Publication date: 2 April 2015 Source:Neuroscience, Volume 290 Author(s): J. Zhu , Q. Liu , Y. Jiang , L. Wu , G. Xu , X. Liu Cellular therapy has provided hope for restoring neurological function post stroke through promoting endogenous neurogenesis, angiogenesis and synaptogenesis. The current study was based on the observation that transplantation of human umbilical cord mesenchymal stem cells (hUCMSCs) promoted the neurological function improvement in stroked mice and meanwhile enhanced angiogenesis in the stroked hemisphere. Grafted hUCMSCs secreted human vascular endothelial growth factor A (VEGF-A). Notch1 signali...
Source: Neuroscience - February 22, 2015 Category: Neuroscience Source Type: research