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Prolonged High Fat Diet Worsens the Cellular Response to a Small, Covert-like Ischemic Stroke
Publication date: Available online 4 February 2019Source: NeuroscienceAuthor(s): Kathleen E. Fifield, Todd M. Rowe, Joanna B. Raman-Nair, Michiru Hirasawa, Jacqueline L. VanderluitAbstractObesity is associated with worse neurological outcomes following overt ischemic strokes. The majority of strokes however, are covert, small strokes that often evade detection. How obesity impacts the cellular response to covert strokes is unclear. Here, we used a diet-induced obesity model by feeding mice a high fat diet (HFD) and examining its impact on the behavioral and cellular responses to either an Endothelin-1-induced focal ischemi...
Source: Neuroscience - February 5, 2019 Category: Neuroscience Source Type: research

Peri-infarct depolarizations during focal ischemia in the awake Spontaneously Hypertensive Rat. Minimizing anesthesia confounds in experimental stroke
Publication date: 14 June 2016 Source:Neuroscience, Volume 325 Author(s): K. Kudo, L. Zhao, T.S. Nowak Anesthesia profoundly impacts peri-infarct depolarizations (PIDs), but only one prior report has described their monitoring during experimental stroke in awake animals. Since temporal patterns of PID occurrence are model specific, the current study examined PID incidence during focal ischemia in the awake Spontaneously Hypertensive Rat (SHR), and documented the impact of both prior and concurrent isoflurane anesthesia. For awake recordings, electrodes were implanted under isoflurane anesthesia 1day to 5weeks prior to...
Source: Neuroscience - April 10, 2016 Category: Neuroscience Source Type: research

Internal capsule stroke in the common marmoset
Publication date: 22 January 2015 Source:Neuroscience, Volume 284 Author(s): S. Puentes , T. Kaido , T. Hanakawa , N. Ichinohe , T. Otsuki , K. Seki White matter (WM) impairment and motor deficit after stroke are directly related. However, WM injury mechanisms and their relation to motor disturbances are still poorly understood. In humans, the anterior choroidal artery (AChA) irrigates the internal capsule (IC), and stroke to this region can induce isolated motor impairment. The goal of this study was to analyze whether AChA occlusion can injure the IC in the marmoset monkey. The vascular distribution of the marmoset bra...
Source: Neuroscience - November 20, 2014 Category: Neuroscience Source Type: research