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Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke
Publication date: 19 November 2016 Source:Neuroscience, Volume 337 Author(s): Honglin Yan, Jingping Yuan, Likun Gao, Jie Rao, Jichang Hu Maternally expressed gene 3 (MEG3) is suggested to function as a long non-coding RNA (lncRNA) and to play roles in various human cancers. However, the functional properties of MEG3 in ischemic stroke remain unknown. Here, we report that expression of MEG3 is upregulated following ischemia in adult mice. Moreover, cerebral ischemia recruits p53 into the MEG3 complex in ischemic tissues. MEG3 directly binds with the p53 DNA binding domain (DBD) consisting of amino acids 271–282 (p53-DBD2...
Source: Neuroscience - October 1, 2016 Category: Neuroscience Source Type: research