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Distinct inflammatory responses differentiate cerebral infarct from transient ischaemic attack
Publication date: Available online 30 September 2016 Source:Journal of Clinical Neuroscience Author(s): Christopher W.L. Armstrong, Erika Bosio, Claire Neil, Simon G.A. Brown, Graeme J. Hankey, Daniel M. Fatovich We previously reported on a 26-year-old patient who presented early during a large and eventually fatal cerebral infarct. Microarray analysis of blood samples from this patient demonstrated initially up-regulated and subsequently down-regulated Granzyme B (GzmB) expression, along with progressive up-regulation of genes for S100 calcium binding protein A12 (S100A12) and matrix metalloproteinase 9 (MMP-9). To confi...
Source: Journal of Clinical Neuroscience - September 30, 2016 Category: Neuroscience Source Type: research

Changes in differential gene expression during a fatal stroke
We present a young woman (with an identical twin sister) who arrived at the Emergency Department (ED) within 1hour of her initial stroke symptoms. Previous microarray studies have demonstrated differential expression of multiple genes between stroke patients and healthy controls. However, for many of these studies there is a significant delay between the initial symptoms and collection of blood samples, potentially leaving the important early activators/regulators of the inflammatory response unrecognised. Blood samples were collected from the patient for an analysis of differential gene expression over time during the evo...
Source: Journal of Clinical Neuroscience - August 29, 2015 Category: Neuroscience Source Type: research