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Vagus Nerve Stimulation for Stroke Motor Recovery —What Is Next?
Source: Translational Stroke Research - June 2, 2022 Category: Neurology Source Type: research

Optimizing Dosing of Vagus Nerve Stimulation for Stroke Recovery
AbstractVagus nerve stimulation (VNS) paired with rehabilitative training enhances recovery of function in models of stroke and is currently under investigation for use in chronic stroke patients. Dosing is critical in translation of pharmacological therapies, but electrical stimulation therapies often fail to comprehensively explore dosing parameters in preclinical studies. Varying VNS parameters has non-monotonic effects on plasticity in the central nervous system, which may directly impact efficacy for stroke. We sought to optimize stimulation intensity to maximize recovery of motor function in a model of ischemic strok...
Source: Translational Stroke Research - June 24, 2020 Category: Neurology Source Type: research

Central Noradrenergic Agonists in the Treatment of Ischemic Stroke —an Overview
AbstractIschemic stroke is the leading cause of morbidity and mortality with a significant health burden worldwide and few treatment options. Among the short- and long-term effects of ischemic stroke is the cardiovascular sympathetic autonomic dysfunction, presented in part as the by-product of the ischemic damage to the noradrenergic centers of the brain. Unlike high levels in the plasma, the brain may face suboptimal levels of norepinephrine (NE), with adverse effects on the clinical and functional outcomes of ischemic stroke. The intravenous administration of NE and other sympathomimetic agents, in an attempt to increas...
Source: Translational Stroke Research - July 19, 2019 Category: Neurology Source Type: research