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Source: Translational Stroke Research
Therapy: Dialysis
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Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man
We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in mouse and cell culture models and studied progression of microbleed burden on serial brain imaging from humans.Mouse studies: Two CKD models were investigated: adenine-induced tubulointerstitial nephritis and surgical 5/6 nephrectomy.Cell culture studies: bEnd.3 mouse brain endothelial cells were grown to confluence, and monolayer integrity was measured after exposure to 5 –15% human uremic serum or increasing concentrations of urea.Human studies: Progression of brain microbleeds was evaluated on serial ...
Source: Translational Stroke Research - May 3, 2019 Category: Neurology Source Type: research
