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Source: JAHA:Journal of the American Heart Association

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Total 381 results found since Jan 2013.

CYP2C19 Metabolizer Status and Clopidogrel Efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) Study Genetics
Conclusions There were significant differences in recurrent stroke by CYP2C19 genotype-inferred metabolizer status in white subcortical stroke patients receiving dual antiplatelet therapy with aspirin and clopidogrel, consistent with cardiovascular studies on CYP2C19 and clopidogrel; however, the bleeding risk that led to early termination of the antiplatelet arm of the SPS3 trial does not appear to be explained by CYP2C19 genotype. This study was relatively underpowered; therefore, these findings should be interpreted with caution and warrant replication. Clinical Trial Registration URL: www.clinicaltrials.gov. Unique id...
Source: JAHA:Journal of the American Heart Association - May 27, 2015 Category: Cardiology Authors: McDonough, C. W., McClure, L. A., Mitchell, B. D., Gong, Y., Horenstein, R. B., Lewis, J. P., Field, T. S., Talbert, R. L., Benavente, O. R., Johnson, J. A., Shuldiner, A. R. Tags: Genetics Source Type: research

Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial Arrhythmia and Electrophysiology
ConclusionsPatients with PAD in ARISTOTLE had a higher crude risk of stroke or systemic embolism compared with patients without PAD that was not present after adjustment. The benefits of apixaban versus warfarin for stroke and systemic embolism were similar in patients with and without PAD. These findings highlight the need to optimize the treatment of patients with atrial fibrillation and PAD.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00412984.
Source: JAHA:Journal of the American Heart Association - January 17, 2017 Category: Cardiology Authors: Hu, P. T., Lopes, R. D., Stevens, S. R., Wallentin, L., Thomas, L., Alexander, J. H., Hanna, M., Lewis, B. S., Verheugt, F. W. A., Granger, C. B., Jones, W. S. Tags: Arrhythmias, Atrial Fibrillation, Anticoagulants, Peripheral Vascular Disease Original Research Source Type: research

Is an Oral Anticoagulant Necessary for Young Atrial Fibrillation Patients With a CHA2DS2-VASc Score of 1 (Men) or 2 (Women)? Arrhythmia and Electrophysiology
Conclusions For atrial fibrillation patients aged 20 to 49 years with 1 risk factor in addition to sex, non–vitamin K antagonist OACs should be considered for stroke prevention to minimize the risk of a potentially fatal or disabling event.
Source: JAHA:Journal of the American Heart Association - October 3, 2016 Category: Cardiology Authors: Hung, Y., Chao, T.-F., Liu, C.-J., Tuan, T.-C., Lin, Y.-J., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Liao, J.-N., Chung, F.-P., Lin, W.-Y., Lin, W.-S., Cheng, S.-M., Chen, T.-J., Lip, G. Y. H., Chen, S.-A. Tags: Atrial Fibrillation Arrhythmia and Electrophysiology Source Type: research

Associations of Stressful Life Events and Social Strain With Incident Cardiovascular Disease in the Women's Health Initiative Epidemiology
Conclusions Higher SLE and social strain were associated with higher incident CVD independent of sociodemographic factors and depressive symptoms, but not behavioral and biological risk factors.
Source: JAHA:Journal of the American Heart Association - June 27, 2014 Category: Cardiology Authors: Kershaw, K. N., Brenes, G. A., Charles, L. E., Coday, M., Daviglus, M. L., Denburg, N. L., Kroenke, C. H., Safford, M. M., Savla, T., Tindle, H. A., Tinker, L. F., Van Horn, L. Tags: Epidemiology Source Type: research

Effects of Cardiac Resynchronization Therapy on Cardiac Remodeling and Contractile Function: Results From Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) Heart Failure
Conclusion In patients with NYHA Class I/II heart failure, cardiac resynchronization therapy exerts favorable changes in left ventricular end-systolic and end-diastolic volumes and the volume intercept. The volume intercept may be useful to gain insight into prognosis in heart failure. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00271154.
Source: JAHA:Journal of the American Heart Association - September 11, 2015 Category: Cardiology Authors: St. John Sutton, M., Cerkvenik, J., Borlaug, B. A., Daubert, C., Gold, M. R., Ghio, S., Chirinos, J. A., Linde, C., Ky, B. Tags: Heart Failure Source Type: research

Prevalence of Eligibility Criteria for the Systolic Blood Pressure Intervention Trial in US Adults Among Excluded Groups: Age
Conclusions A substantial percentage of US adults with diabetes mellitus or history of stroke and a small percentage <50 years old meet the other SPRINT eligibility criteria.
Source: JAHA:Journal of the American Heart Association - July 11, 2016 Category: Cardiology Authors: Bress, A. P., Tanner, R. M., Hess, R., Gidding, S. S., Colantonio, L. D., Shimbo, D., Muntner, P. Tags: Epidemiology, High Blood Pressure, Hypertension Source Type: research

Clinical and Magnetic Resonance Imaging Predictors of Very Early Neurological Response to Intravenous Thrombolysis in Patients With Middle Cerebral Artery Occlusion Cardiovascular Surgery
Conclusions Lack of VENI provides an early estimate of 3-month outcome and recanalization after IV-tPA. Baseline NIHSS, onset to treatment time, and diffusion weighted imaging—Alberta Stroke Programme Early CT Score could help to predict lack of VENI and, in turn, might help early selection of candidates for complementary reperfusion strategies.
Source: JAHA:Journal of the American Heart Association - December 5, 2013 Category: Cardiology Authors: Apoil, M., Turc, G., Tisserand, M., Calvet, D., Naggara, O., Domigo, V., Baron, J.-C., Oppenheim, C., Touze, E. Tags: Cardiovascular Surgery Source Type: research

Prospective National Study of the Prevalence, Incidence, Management and Outcome of a Large Contemporary Cohort of Patients With Incident Non-Valvular Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions In the present study the prevalence and incidence of AF, stroke, and death were comparable to those reported in Europe and North America. The low use of anticoagulation calls for measures to increase adherence to current treatment recommendations in order to improve outcomes.
Source: JAHA:Journal of the American Heart Association - January 21, 2015 Category: Cardiology Authors: Haim, M., Hoshen, M., Reges, O., Rabi, Y., Balicer, R., Leibowitz, M. Tags: Arrhythmia and Electrophysiology Source Type: research

Obesity and Subtypes of Incident Cardiovascular Disease Epidemiology
Conclusions The link between obesity and HF was stronger than those for other CVD subtypes and was uniquely unexplained by traditional risk factors. Weight management is likely critical for optimal HF prevention, and nontraditional pathways linking obesity to HF need to be elucidated.
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Ndumele, C. E., Matsushita, K., Lazo, M., Bello, N., Blumenthal, R. S., Gerstenblith, G., Nambi, V., Ballantyne, C. M., Solomon, S. D., Selvin, E., Folsom, A. R., Coresh, J. Tags: Cardiovascular Disease, Epidemiology, Obesity Source Type: research

Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvencion con DIeta MEDiterranea (PREDIMED) Trial Epidemiology
Conclusions Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels. Clinical Trial Registration URL: www.controlled-trials.com. Unique identifier: ISRCTN 35739639.
Source: JAHA:Journal of the American Heart Association - September 14, 2016 Category: Cardiology Authors: Zheng, Y., Hu, F. B., Ruiz-Canela, M., Clish, C. B., Dennis, C., Salas-Salvado, J., Hruby, A., Liang, L., Toledo, E., Corella, D., Ros, E., Fito, M., Gomez-Gracia, E., Aros, F., Fiol, M., Lapetra, J., Serra-Majem, L., Estruch, R., Martinez-Gonzalez, M. A. Tags: Etiology, Cardiovascular Disease, Diet and Nutrition, Epidemiology, Acute Coronary Syndromes Source Type: research

Psoriasis and Major Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis of Observational Studies Epidemiology
Conclusions Mild and severe psoriasis are associated with an increased risk of myocardial infarction and stroke. Severe psoriasis is also associated with an increased risk of cardiovascular mortality. Future studies should include more complete covariate adjustment and characterization of psoriasis severity.
Source: JAHA:Journal of the American Heart Association - April 4, 2013 Category: Cardiology Authors: Armstrong, E. J., Harskamp, C. T., Armstrong, A. W. Tags: Epidemiology Source Type: research

Reduction in Overall Occurrences of Ischemic Events With Vorapaxar: Results From TRACER Coronary Heart Disease
Conclusions Vorapaxar reduced overall occurrences of ischemic events, but increased bleeding. These exploratory findings broaden our understanding of vorapaxar's potential and expand our understanding of the value of capturing recurrent events. Clinical Trial Registration URL: ClinicalTrials.gov. Unique identifier: NCT00527943.
Source: JAHA:Journal of the American Heart Association - July 10, 2014 Category: Cardiology Authors: White, H. D., Huang, Z., Tricoci, P., Van de Werf, F., Wallentin, L., Lokhnygina, Y., Moliterno, D. J., Aylward, P. E., Mahaffey, K. W., Armstrong, P. W. Tags: Coronary Heart Disease Source Type: research

Resistive and Pulsatile Arterial Hemodynamics and Cardiovascular Events: The Multiethnic Study of Atherosclerosis Heart Failure
Conclusions Greater total arterial compliance, manifest by higher stroke volume/pulse pressure is associated with a reduced incidence of subsequent CVE. In contrast, SVR was not independently associated with CVE in subjects free of overt cardiovascular disease at baseline. These findings support the concept that alternations in the large conduit vessels, rather than changes in microvascular resistance, are primarily related to incident cardiovascular disease.
Source: JAHA:Journal of the American Heart Association - December 11, 2014 Category: Cardiology Authors: Lilly, S. M., Jacobs, D., Bluemke, D. A., Duprez, D., Zamani, P., Chirinos, J. Tags: Heart Failure Source Type: research

The Effect of Hurricane Sandy on Cardiovascular Events in New Jersey Epidemiology
Conclusion In the 2 weeks following Hurricane Sandy, there were increases in the incidence of, and 30-day mortality from, MI and in the incidence of stroke.
Source: JAHA:Journal of the American Heart Association - December 8, 2014 Category: Cardiology Authors: Swerdel, J. N., Janevic, T. M., Cosgrove, N. M., Kostis, J. B., the Myocardial Infarction Data Acquisition System (MIDAS 24) Study Group Tags: Epidemiology Source Type: research