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Source: JAHA:Journal of the American Heart Association
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Total 381 results found since Jan 2013.
Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease Coronary Heart Disease
Conclusions
Although high Lp-PLA2 activity was associated with increased risk of cardiovascular events, pharmacological lowering of Lp-PLA2 activity by 65% did not significantly reduce cardiovascular events in patients with stable coronary heart disease, regardless of the baseline level or the magnitude of change of Lp-PLA2 activity.
Clinical Trial Registration
URL: https://www.clinicaltrials.gov. Unique identifier: NCT00799903.
Source: JAHA:Journal of the American Heart Association - June 20, 2016 Category: Cardiology Authors: Wallentin, L., Held, C., Armstrong, P. W., Cannon, C. P., Davies, R. Y., Granger, C. B., Hagström, E., Harrington, R. A., Hochman, J. S., Koenig, W., Krug-Gourley, S., Mohler, E. R., Siegbahn, A., Tarka, E., Steg, P. G., Stewart, R. A. H., Weiss, Tags: Biomarkers, Risk Factors, Pharmacology, Treatment, Coronary Artery Disease Coronary Heart Disease Source Type: research
Impact of Sleep-Disordered Breathing on Long-Term Outcomes in Patients With Acute Coronary Syndrome Who Have Undergone Primary Percutaneous Coronary Intervention Coronary Heart Disease
Conclusions
The study's results showed that the presence of SDB among patients with acute coronary syndrome following primary percutaneous coronary intervention is associated with a higher incidence of major adverse cardiocerebrovascular events during long-term follow-up.
Source: JAHA:Journal of the American Heart Association - June 14, 2016 Category: Cardiology Authors: Mazaki, T., Kasai, T., Yokoi, H., Kuramitsu, S., Yamaji, K., Morinaga, T., Masuda, H., Shirai, S., Ando, K. Tags: Risk Factors, Quality and Outcomes, Acute Coronary Syndromes Coronary Heart Disease Source Type: research
Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction Coronary Heart Disease
Conclusion
High levels of sIL-6R were associated with future cardiovascular events and mortality in STEMI patients, suggesting an important role of the IL-6 signaling system.
Source: JAHA:Journal of the American Heart Association - June 12, 2016 Category: Cardiology Authors: Ritschel, V. N., Seljeflot, I., Arnesen, H., Halvorsen, S., Eritsland, J., Fagerland, M. W., Andersen, G. O. Tags: Biomarkers, Inflammation, Ischemia Coronary Heart Disease Source Type: research
High-Fat-Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders Vascular Medicine
Conclusions
High-fat diet, independently of metabolic disorders, significantly promotes the progression of AD-like pathology through enhancement of cerebral amyloid angiopathy and oxidative stress.
Source: JAHA:Journal of the American Heart Association - June 12, 2016 Category: Cardiology Authors: Lin, B., Hasegawa, Y., Takane, K., Koibuchi, N., Cao, C., Kim-Mitsuyama, S. Tags: Diet and Nutrition, Cerebrovascular Disease/Stroke, Cognitive Impairment Vascular Medicine Source Type: research
Transcatheter Aortic Valve Implantation With or Without Preimplantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-Analysis Interventional Cardiology
Conclusions
Our analysis suggests that TAVI procedures with or without preimplantation BAV were associated with similar outcomes for a number of clinically relevant end points. Further studies including a large number of patients are needed to ascertain the impact of TAVI without preimplantation BAV as a standard practice.
Source: JAHA:Journal of the American Heart Association - June 12, 2016 Category: Cardiology Authors: Bagur, R., Kwok, C. S., Nombela-Franco, L., Ludman, P. F., de Belder, M. A., Sponga, S., Gunning, M., Nolan, J., Diamantouros, P., Teefy, P. J., Kiaii, B., Chu, M. W. A., Mamas, M. A. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Catheter-Based Coronary and Valvular Interventions Interventional Cardiology Source Type: research
No Decline in the Risk of Stroke Following Incident Atrial Fibrillation Since 2000 in the Community: A Concerning Trend Epidemiology
Conclusions
Strokes/TIAs are frequent after AF, occurring in 10% of patients after 5 years of follow-up. The occurrence of stroke/TIA did not decline over the last decade, which may be influenced by a leveling off of anticoagulation use. This concerning trend has major public health implications.
Source: JAHA:Journal of the American Heart Association - June 12, 2016 Category: Cardiology Authors: Chamberlain, A. M., Brown, R. D., Alonso, A., Gersh, B. J., Killian, J. M., Weston, S. A., Roger, V. L. Tags: Atrial Fibrillation, Epidemiology, Ischemic Stroke, Transient Ischemic Attack (TIA) Source Type: research
Effectiveness and Safety of Dabigatran, Rivaroxaban, and Apixaban Versus Warfarin in Nonvalvular Atrial Fibrillation Health Services and Outcomes Research
Conclusions
In patients with nonvalvular atrial fibrillation, apixaban was associated with lower risks of both stroke and major bleeding, dabigatran was associated with similar risk of stroke but lower risk of major bleeding, and rivaroxaban was associated with similar risks of both stroke and major bleeding in comparison to warfarin.
Source: JAHA:Journal of the American Heart Association - June 12, 2016 Category: Cardiology Authors: Yao, X., Abraham, N. S., Sangaralingham, L. R., Bellolio, M. F., McBane, R. D., Shah, N. D., Noseworthy, P. A. Tags: Atrial Fibrillation, Secondary Prevention, Anticoagulants, Transplantation, Cerebrovascular Disease/Stroke Health Services and Outcomes Research Source Type: research
Accuracy of ICD-9-CM Codes by Hospital Characteristics and Stroke Severity: Paul Coverdell National Acute Stroke Program Health Services and Outcomes Research
Conclusions
We identified disagreements in stroke/TIA coding by hospital characteristics and stroke severity, particularly for milder ischemic strokes. Such systematic variations in ICD-9-CM coding practices can affect stroke case identification in epidemiological studies and may have implications for hospital-level quality metrics.
Source: JAHA:Journal of the American Heart Association - May 30, 2016 Category: Cardiology Authors: Chang, T. E., Lichtman, J. H., Goldstein, L. B., George, M. G. Tags: Health Services, Quality and Outcomes Health Services and Outcomes Research Source Type: research
Dairy Consumption and Risk of Stroke: A Systematic Review and Updated Dose-Response Meta-Analysis of Prospective Cohort Studies Arrhythmia and Electrophysiology
Conclusions
Milk and cheese consumption were inversely associated with stroke risk. Results should be placed in the context of the observed heterogeneity. Future epidemiological studies should provide more details about dairy types, including fat content. In addition, the role of dairy in Asian populations deserves further attention.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: de Goede, J., Soedamah-Muthu, S. S., Pan, A., Gijsbers, L., Geleijnse, J. M. Tags: Cardiovascular Disease Arrhythmia and Electrophysiology Source Type: research
Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) Stroke
Conclusions
Small+medium HDL-P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL-P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Kim, D. S., Li, Y. K., Bell, G. A., Burt, A. A., Vaisar, T., Hutchins, P. M., Furlong, C. E., Otvos, J. D., Polak, J. F., Arnan, M. K., Kaufman, J. D., McClelland, R. L., Longstreth, W. T., Jarvik, G. P. Tags: Lipids and Cholesterol, Oxidant Stress, Cardiovascular Disease, Cerebrovascular Disease/Stroke Source Type: research
Derivation and Validation of a Modified Short Form of the Stroke Impact Scale Stroke
Conclusions
Using multiple, complementary methods, we have derived an SF-SIS and demonstrated content, convergent, and discriminant validity. This shortened SIS should allow collection of robust quality of life data with less associated test burden.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: MacIsaac, R., Ali, M., Peters, M., English, C., Rodgers, H., Jenkinson, C., Lees, K. R., Quinn, T. J., the VISTA Collaboration Tags: Stroke Source Type: research
Comparative Effectiveness of Interventions for Stroke Prevention in Atrial Fibrillation: A Network Meta-Analysis Arrhythmia and Electrophysiology
Conclusions
The entire spectrum of therapy to prevent thromboembolism in nonvalvular AF significantly reduced stroke/systemic embolism events and mortality.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Tereshchenko, L. G., Henrikson, C. A., Cigarroa, J., Steinberg, J. S. Tags: Atrial Fibrillation, Anticoagulants, Treatment, Meta Analysis, Cerebrovascular Disease/Stroke Arrhythmia and Electrophysiology Source Type: research
Intravenous Thrombolysis for Acute Ischemic Stroke in Patients Receiving Antiplatelet Therapy: A Systematic Review and Meta-analysis of 19 Studies Stroke
Conclusions
Patients with acute ischemic stroke receiving long-term antiplatelet medications were associated with greater risks of developing symptomatic intracranial hemorrhage after systemic thrombolysis. However, the overall independent association between prestroke antiplatelet therapy and unfavorable outcomes or mortality was insignificant.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Luo, S., Zhuang, M., Zeng, W., Tao, J. Tags: Meta Analysis, Quality and Outcomes, Ischemic Stroke Source Type: research
Stroke Ready Intervention: Community Engagement to Decrease Prehospital Delay Stroke
Conclusions
Stroke Ready increased stroke preparedness, a necessary step toward increasing acute stroke treatment rates.
Clinical Trial Registration
URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01499173.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Skolarus, L. E., Zimmerman, M. A., Bailey, S., Dome, M., Murphy, J. B., Kobrossi, C., Dombrowski, S. U., Burke, J. F., Morgenstern, L. B. Tags: Race and Ethnicity, Cerebrovascular Disease/Stroke Source Type: research
Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial Stroke
Conclusions
Age has a greater influence on major bleeding than thromboembolic risk in patients with atrial fibrillation. Given the higher rates of bleeding and death with increasing age, treatment of elderly patients with edoxaban provides an even greater absolute reduction in safety events over warfarin, compared to treatment with edoxaban versus warfarin in younger patients.
Clinical Trial Registration
URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00781391.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Kato, E. T., Giugliano, R. P., Ruff, C. T., Koretsune, Y., Yamashita, T., Kiss, R. G., Nordio, F., Murphy, S. A., Kimura, T., Jin, J., Lanz, H., Mercuri, M., Braunwald, E., Antman, E. M. Tags: Atrial Fibrillation, Complications, Mortality/Survival, Intracranial Hemorrhage, Ischemic Stroke Source Type: research