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Comparative Effectiveness and Safety of Dabigatran and Rivaroxaban in Atrial Fibrillation Patients Arrhythmia and Electrophysiology
ConclusionsRivaroxaban therapy was associated with a statistically significant increase in all‐cause death compared with dabigatran therapy in atrial fibrillation patients.
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Lai, C.-L., Chen, H.-M., Liao, M.-T., Lin, T.-T., Chan, K. A. Tags: Arrhythmias, Anticoagulants, Pharmacology, Cerebrovascular Disease/Stroke Original Research Source Type: research

Time in Therapeutic Range and Outcomes After Warfarin Initiation in Newly Diagnosed Atrial Fibrillation Patients With Renal Dysfunction Kidney in Cardiovascular Disease
BackgroundIt is unknown whether renal dysfunction conveys poor anticoagulation control in warfarin‐treated patients with atrial fibrillation and whether poor anticoagulation control associates with the risk of adverse outcomes in these patients.Methods and ResultsThis was an observational study from the Stockholm CREatinine Measurements (SCREAM) cohort including all newly diagnosed atrial fibrillation patients initiating treatment with warfarin (n=7738) in Stockholm, Sweden, between 2006 and 2011. Estimated glomerular filtration rate (eGFR; mL/min per 1.73 m2) was calculated from serum creatinine. Time‐in‐therapeuti...
Source: JAHA:Journal of the American Heart Association - March 1, 2017 Category: Cardiology Authors: Szummer, K., Gasparini, A., Eliasson, S., Arnlov, J., Qureshi, A. R., Barany, P., Evans, M., Friberg, L., Carrero, J. J. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Cardiovascular Disease, Anticoagulants, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study Arrhythmia and Electrophysiology
ConclusionsAlthough family history of AF is associated with increased likelihood for development of AF, once AF developed, long‐term risks of death and thromboembolic complications were similar in familial and nonfamilial AF patients.
Source: JAHA:Journal of the American Heart Association - November 18, 2016 Category: Cardiology Authors: Gundlund, A., Olesen, J. B., Staerk, L., Lee, C., Piccini, J. P., Peterson, E. D., Kober, L., Torp-Pedersen, C., Gislason, G. H., Fosbol, E. L. Tags: Atrial Fibrillation, Epidemiology Original Research Source Type: research

Short-Term Risk of Bleeding During Heparin Bridging at Initiation of Vitamin K Antagonist Therapy in More Than 90 000 Patients With Nonvalvular Atrial Fibrillation Managed in Outpatient Care Epidemiology
BackgroundSeveral studies have recently examined the risks of bleeding and of ischemic stroke and systemic embolism associated with perioperative heparin bridging anticoagulation in patients with nonvalvular atrial fibrillation. However, few studies have investigated bridging risks during vitamin K antagonist initiation in outpatient settings.Methods and ResultsA retrospective cohort study was conducted on individuals starting oral anticoagulation between January 2010 and November 2014 for nonvalvular atrial fibrillation managed in outpatient care and identified from French healthcare insurance. Bleeding and ischemic strok...
Source: JAHA:Journal of the American Heart Association - October 30, 2016 Category: Cardiology Authors: Bouillon, K., Bertrand, M., Boudali, L., Ducimetiere, P., Dray-Spira, R., Zureik, M. Tags: Atrial Fibrillation, Epidemiology Original Research Source Type: research

Is an Oral Anticoagulant Necessary for Young Atrial Fibrillation Patients With a CHA2DS2-VASc Score of 1 (Men) or 2 (Women)? Arrhythmia and Electrophysiology
ConclusionsFor atrial fibrillation patients aged 20 to 49 years with 1 risk factor in addition to sex, non–vitamin K antagonist OACs should be considered for stroke prevention to minimize the risk of a potentially fatal or disabling event.
Source: JAHA:Journal of the American Heart Association - October 3, 2016 Category: Cardiology Authors: Hung, Y., Chao, T.-F., Liu, C.-J., Tuan, T.-C., Lin, Y.-J., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Liao, J.-N., Chung, F.-P., Lin, W.-Y., Lin, W.-S., Cheng, S.-M., Chen, T.-J., Lip, G. Y. H., Chen, S.-A. Tags: Atrial Fibrillation Original Research Source Type: research

Detection of Atrial Fibrillation Among Patients With Stroke Due to Large or Small Vessel Disease: A Meta-Analysis Stroke
ConclusionsAF detection rate is similar in patients with small and large vessel strokes (2.2–2.4%). Because no studies reported on extended monitoring (>7 days) in these stroke populations, we could not estimate the yield of AF detection with long‐term cardiac monitoring. Randomized controlled trials are needed to examine the utility of AF detection with long‐term cardiac monitoring (>7 days) in this patient population.
Source: JAHA:Journal of the American Heart Association - September 25, 2016 Category: Cardiology Authors: Demeestere, J., Fieuws, S., Lansberg, M. G., Lemmens, R. Tags: Atrial Fibrillation, Secondary Prevention, Anticoagulants, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta-Analysis and Systematic Review Arrhythmia and Electrophysiology
ConclusionsUnderweight BMI is associated with an increased risk of stroke or systemic embolism, cardiovascular death, and all‐cause death in Asian patients with atrial fibrillation, whereas in all atrial fibrillation patients, overweight and obese BMI was not associated with increased risks of these outcomes.
Source: JAHA:Journal of the American Heart Association - September 8, 2016 Category: Cardiology Authors: Zhu, W., Wan, R., Liu, F., Hu, J., Huang, L., Li, J., Hong, K. Tags: Arrhythmias, Atrial Fibrillation, Obesity, Risk Factors Original Research Source Type: research

Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study Epidemiology
Conclusions Proximal depressive symptoms were associated with incident fatal and nonfatal stroke and CVD death even after controlling for multiple explanatory factors, further supporting the urgent need for timely management of depressive symptoms.
Source: JAHA:Journal of the American Heart Association - August 11, 2016 Category: Cardiology Authors: Moise, N., Khodneva, Y., Richman, J., Shimbo, D., Kronish, I., Safford, M. M. Tags: Quality and Outcomes Epidemiology Source Type: research

Stability of High-Quality Warfarin Anticoagulation in a Community-Based Atrial Fibrillation Cohort: The Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study Epidemiology
Conclusions Nearly 60% of AF patients with high-quality TTR1 on warfarin maintained TTR ≥70% over the next 6 months. A minority deteriorated to very poor TTR. Patient features did not strongly predict TTR in the second 6-month period. Our analyses support watchful waiting for AF patients with initial high-quality warfarin anticoagulation before considering alternative anticoagulants.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Dallalzadeh, L. O., Go, A. S., Chang, Y., Borowsky, L. H., Fang, M. C., Singer, D. E. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Anticoagulants Source Type: research

Ischemic Stroke Risk After Acute Coronary Syndrome Stroke
Conclusions Non-STEMI and STEMI confer an equally increased risk of IS. Studies exploring IS mechanisms in cardiac patients are needed to improve and tailor stroke prevention strategies.
Source: JAHA:Journal of the American Heart Association - July 12, 2016 Category: Cardiology Authors: Yaghi, S., Pilot, M., Song, C., Blum, C. A., Yakhkind, A., Silver, B., Furie, K. L., Elkind, M. S. V., Sherzai, D., Sherzai, A. Z. Tags: Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Source Type: research

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