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Effect Modification of Long-Term Air Pollution Exposures and the Risk of Incident Cardiovascular Disease in US Women Epidemiology
Conclusions In this nationwide cohort, women with diabetes were identified as the subpopulation most sensitive to the adverse cardiovascular health effects of PM.
Source: JAHA:Journal of the American Heart Association - November 25, 2015 Category: Cardiology Authors: Hart, J. E., Puett, R. C., Rexrode, K. M., Albert, C. M., Laden, F. Tags: Epidemiology Source Type: research

Neuropsychological Status and Structural Brain Imaging in Adolescents With Single Ventricle Who Underwent the Fontan Procedure Congenital Heart Disease
Conclusions The neuropsychological deficits and high frequencies of structural brain abnormalities in adolescents who underwent the Fontan procedure highlight the need for research on interventions to improve the long-term outcomes in this high-risk group.
Source: JAHA:Journal of the American Heart Association - December 14, 2015 Category: Cardiology Authors: Bellinger, D. C., Watson, C. G., Rivkin, M. J., Robertson, R. L., Roberts, A. E., Stopp, C., Dunbar-Masterson, C., Bernson, D., DeMaso, D. R., Wypij, D., Newburger, J. W. Tags: Congenital Heart Disease Source Type: research

Incremental Value of the CRUSADE, ACUITY, and HAS-BLED Risk Scores for the Prediction of Hemorrhagic Events After Coronary Stent Implantation in Patients Undergoing Long or Short Duration of Dual Antiplatelet Therapy Coronary Heart Disease
Conclusions Our analysis suggests that the CRUSADE score predicts major bleeding similarly to ACUITY and better than HAS BLED in an all-comer population with percutaneous coronary intervention and potentially identifies patients at higher risk of hemorrhagic complications when treated with a long-term dual antiplatelet therapy regimen. Clinical Trial Registration URL: http://clinicaltrials.gov. Unique identifier: NCT00611286.
Source: JAHA:Journal of the American Heart Association - December 7, 2015 Category: Cardiology Authors: Costa, F., Tijssen, J. G., Ariotti, S., Giatti, S., Moscarella, E., Guastaroba, P., De Palma, R., Ando, G., Oreto, G., Zijlstra, F., Valgimigli, M. Tags: Coronary Heart Disease Source Type: research

Dietary {alpha}-Linolenic Acid, Marine {omega}-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvencion con DIeta MEDiterranea (PREDIMED) Study Epidemiology
Conclusions In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639.
Source: JAHA:Journal of the American Heart Association - January 26, 2016 Category: Cardiology Authors: Sala-Vila, A., Guasch-Ferre, M., Hu, F. B., Sanchez-Tainta, A., Bullo, M., Serra-Mir, M., Lopez-Sabater, C., Sorli, J. V., Aros, F., Fiol, M., Munoz, M. A., Serra-Majem, L., Martinez, J. A., Corella, D., Fito, M., Salas-Salvado, J., Martinez-Gonzalez, M. Tags: Diet and Nutrition Epidemiology Source Type: research

Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Strain in Patients With Significant Aortic Stenosis Valvular Heart Disease
Conclusions In normal LVEF patients with significant aortic stenosis, BNP and LV-GLS provide incremental (additive not duplicative) prognostic information over established predictors, suggesting that both play a synergistic role in defining outcomes.
Source: JAHA:Journal of the American Heart Association - January 5, 2016 Category: Cardiology Authors: Goodman, A., Kusunose, K., Popovic, Z. B., Parikh, R., Barr, T., Sabik, J. F., Rodriguez, L. L., Svensson, L. G., Griffin, B. P., Desai, M. Y. Tags: Metabolism, Valvular Heart Disease, Echocardiography, Cardiovascular Surgery Source Type: research

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain Coronary Heart Disease
Conclusion Low plasma homoarginine was identified as a risk marker for incident MACEs in patients with acute chest pain, in particular, in those with elevated hsTnI. Impaired homoarginine was associated with prevalent AF. Further studies are needed to investigate the link to AF and evaluate homoarginine as a therapeutic option for these patients.
Source: JAHA:Journal of the American Heart Association - April 12, 2016 Category: Cardiology Authors: Atzler, D., Baum, C., Ojeda, F., Keller, T., Cordts, K., Schnabel, R. B., Choe, C.-u., Lackner, K. J., Münzel, T., Böger, R. H., Blankenberg, S., Schwedhelm, E., Zeller, T. Tags: Atrial Fibrillation, Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Acute Coronary Syndromes Coronary Heart Disease Source Type: research

Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis Valvular Heart Disease
Conclusions Six-month mortality after IE is 25% and is predicted by host factors, IE characteristics, and IE complications. Surgery during the index hospitalization is associated with lower mortality but is performed less frequently in the highest risk patients. A simplified risk model may be used to identify specific risk subgroups in IE.
Source: JAHA:Journal of the American Heart Association - April 17, 2016 Category: Cardiology Authors: Park, L. P., Chu, V. H., Peterson, G., Skoutelis, A., Lejko-Zupa, T., Bouza, E., Tattevin, P., Habib, G., Tan, R., Gonzalez, J., Altclas, J., Edathodu, J., Fortes, C. Q., Siciliano, R. F., Pachirat, O., Kanj, S., Wang, A., for the International Collaborat Tags: Clinical Studies, Infectious Endocarditis, Valvular Heart Disease, Mortality/Survival Source Type: research

Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction Coronary Heart Disease
Conclusion High levels of sIL-6R were associated with future cardiovascular events and mortality in STEMI patients, suggesting an important role of the IL-6 signaling system.
Source: JAHA:Journal of the American Heart Association - June 12, 2016 Category: Cardiology Authors: Ritschel, V. N., Seljeflot, I., Arnesen, H., Halvorsen, S., Eritsland, J., Fagerland, M. W., Andersen, G. O. Tags: Biomarkers, Inflammation, Ischemia Coronary Heart Disease Source Type: research

Impact of Sleep-Disordered Breathing on Long-Term Outcomes in Patients With Acute Coronary Syndrome Who Have Undergone Primary Percutaneous Coronary Intervention Coronary Heart Disease
Conclusions The study's results showed that the presence of SDB among patients with acute coronary syndrome following primary percutaneous coronary intervention is associated with a higher incidence of major adverse cardiocerebrovascular events during long-term follow-up.
Source: JAHA:Journal of the American Heart Association - June 14, 2016 Category: Cardiology Authors: Mazaki, T., Kasai, T., Yokoi, H., Kuramitsu, S., Yamaji, K., Morinaga, T., Masuda, H., Shirai, S., Ando, K. Tags: Risk Factors, Quality and Outcomes, Acute Coronary Syndromes Coronary Heart Disease Source Type: research

Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease Coronary Heart Disease
Conclusions Although high Lp-PLA2 activity was associated with increased risk of cardiovascular events, pharmacological lowering of Lp-PLA2 activity by 65% did not significantly reduce cardiovascular events in patients with stable coronary heart disease, regardless of the baseline level or the magnitude of change of Lp-PLA2 activity. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00799903.
Source: JAHA:Journal of the American Heart Association - June 20, 2016 Category: Cardiology Authors: Wallentin, L., Held, C., Armstrong, P. W., Cannon, C. P., Davies, R. Y., Granger, C. B., Hagström, E., Harrington, R. A., Hochman, J. S., Koenig, W., Krug-Gourley, S., Mohler, E. R., Siegbahn, A., Tarka, E., Steg, P. G., Stewart, R. A. H., Weiss, Tags: Biomarkers, Risk Factors, Pharmacology, Treatment, Coronary Artery Disease Coronary Heart Disease Source Type: research

Universal Classification System Type of Incident Myocardial Infarction in Patients With Stable Atherosclerosis: Observations From Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2{degrees}P)-TIMI 50 Coronary Heart Disease
Conclusions Among stable patients with established atherosclerosis, the most common type of incident MI is spontaneous MI, and the reduction in MI with vorapaxar was consistent across MIs of varying type and size, including spontaneous infarctions ≥10x upper reference limit. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00526474.
Source: JAHA:Journal of the American Heart Association - July 17, 2016 Category: Cardiology Authors: Kidd, S. K., Bonaca, M. P., Braunwald, E., De Ferrari, G. M., Lewis, B. S., Merlini, P. A., Murphy, S. A., Scirica, B. M., White, H. D., Morrow, D. A. Tags: Clinical Studies, Ischemia, Platelets Coronary Heart Disease Source Type: research

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study Kidney in Cardiovascular Disease
Conclusions Even mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10-year Framingham risk for CHD and 10-year ASCVD risk among Chinese adults.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Lu, J., Mu, Y., Su, Q., Shi, L., Liu, C., Zhao, J., Chen, L., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Sun, J., Tags: Cardiovascular Disease, Epidemiology, Lifestyle, Risk Factors Kidney in Cardiovascular Disease Source Type: research

Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent Predictor of Poor Prognosis After Myocardial Infarction Coronary Heart Disease
Conclusions Nocturnal hypoxemia in OSA is an important predictor of poor prognosis for patients after MI. These findings suggest that routine use of low-cost nocturnal oximetry may be an economical and practical approach to stratify risk in post-MI patients.
Source: JAHA:Journal of the American Heart Association - July 26, 2016 Category: Cardiology Authors: Xie, J., Sert Kuniyoshi, F. H., Covassin, N., Singh, P., Gami, A. S., Wang, S., Chahal, C. A. A., Wei, Y., Somers, V. K. Tags: Risk Factors, Acute Coronary Syndromes Coronary Heart Disease Source Type: research

Physical Activity, Parental History of Premature Coronary Heart Disease, and Incident Atherosclerotic Cardiovascular Disease in the Atherosclerosis Risk in Communities (ARIC) Study Preventive Cardiology
Conclusions PA was associated with a reduced risk of ASCVD among individuals with and without a FHx of premature CHD.
Source: JAHA:Journal of the American Heart Association - August 29, 2016 Category: Cardiology Authors: Florido, R., Zhao, D., Ndumele, C. E., Lutsey, P. L., McEvoy, J. W., Windham, B. G., Pankow, J. S., Guallar, E., Michos, E. D. Tags: Epidemiology, Exercise, Lifestyle, Primary Prevention, Risk Factors Preventive Cardiology Source Type: research

Ventricular-Arterial Function and Coupling in the Adult Fontan Circulation Congenital Heart Disease
Conclusions Adult Fontan patients have contractile and diastolic dysfunction with normal afterload, impaired VA coupling, and reduced ventricular efficiency with heightened sensitivity to heart rate. Maintenance of CI is dependent on lower afterload, eccentric remodeling, and relative preservation of diastolic function. These data contribute to our understanding of circulatory physiology in adult Fontan patients.
Source: JAHA:Journal of the American Heart Association - September 22, 2016 Category: Cardiology Authors: Saiki, H., Eidem, B. W., Ohtani, T., Grogan, M. A., Redfield, M. M. Tags: Congenital Heart Disease, Cardiovascular Surgery Source Type: research

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