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Individual and Combined Risk Factors for Incident Atrial Fibrillation and Incident Stroke: An Analysis of 3 Million At-Risk US Patients Arrhythmia and Electrophysiology
Conclusions Adults with combinations of known risk factors are at increased risk of incident AF and stroke, but combinations of risk factors are not always additive.
Source: JAHA:Journal of the American Heart Association - July 23, 2015 Category: Cardiology Authors: Chyou, J. Y., Hunter, T. D., Mollenkopf, S. A., Turakhia, M. P., Reynolds, M. R. Tags: Arrhythmia and Electrophysiology Source Type: research

Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction Heart Failure
Conclusion Increased stiffness is the major early pathological process that predisposes to congestive heart failure without abnormalities in systolic function and relaxation in a clinically relevant animal model of aortic stenosis.
Source: JAHA:Journal of the American Heart Association - May 20, 2015 Category: Cardiology Authors: Ishikawa, K., Aguero, J., Oh, J. G., Hammoudi, N., A. Fish, L., Leonardson, L., Picatoste, B., Santos-Gallego, C. G., M. Fish, K., Hajjar, R. J. Tags: Heart Failure Source Type: research

Patient Outcomes According to Adherence to Treatment Guidelines for Rhythm Control of Atrial Fibrillation Coronary Heart Disease
Conclusions Adherence to published guidelines in the antiarrhythmic management of AF is associated with improved patient outcomes.
Source: JAHA:Journal of the American Heart Association - April 6, 2015 Category: Cardiology Authors: Qin, D., Leef, G., Alam, M. B., Rattan, R., Munir, M. B., Patel, D., Khattak, F., Vaghasia, N., Adelstein, E., Jain, S. K., Saba, S. Tags: Coronary Heart Disease Source Type: research

Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community-Based Cohort of African Americans Epidemiology
Conclusions In our community-based sample of African Americans, baseline BMI and BP, and change in BP on follow-up were key determinants of increase in standardized log-LVMI, which in turn carried an adverse prognosis, underscoring the need for greater control of BP and weight in this group.
Source: JAHA:Journal of the American Heart Association - February 5, 2015 Category: Cardiology Authors: Fox, E. R., Musani, S. K., Samdarshi, T. E., Taylor, J. K., Beard, W. L., Sarpong, D. F., Xanthakis, V., McClendon, E. E., Liebson, P. R., Skelton, T. N., Butler, K. R., Mosley, T. H., Taylor, H., Vasan, R. S. Tags: Epidemiology Source Type: research

Predictors of Long-term Clinical Endpoints in Patients With Refractory Angina Coronary Heart Disease
Conclusions Clinically stable patients with RA who are medically managed have a modest mortality, but a high incidence of hospitalization and resource use over 3 years. These findings point to the need for novel therapies aimed at symptom mitigation in this population and their potential impact on health care utilization and costs.
Source: JAHA:Journal of the American Heart Association - January 30, 2015 Category: Cardiology Authors: Povsic, T. J., Broderick, S., Anstrom, K. J., Shaw, L. K., Ohman, E. M., Eisenstein, E. L., Smith, P. K., Alexander, J. H. Tags: Coronary Heart Disease Source Type: research

Cardiac Hemodynamics are Linked With Structural and Functional Features of Brain Aging: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study Epidemiology
Conclusions A graded decrease in cardiac functioning is associated with features of brain aging. Older persons with cardiac or cognitive signs and symptoms may have both cardiac and cerebral diseases and should be evaluated accordingly.
Source: JAHA:Journal of the American Heart Association - January 27, 2015 Category: Cardiology Authors: Sabayan, B., van Buchem, M. A., Sigurdsson, S., Zhang, Q., Harris, T. B., Gudnason, V., Arai, A. E., Launer, L. J. Tags: Epidemiology Source Type: research

Abnormal Stress-Related Measures of Arterial Stiffness in Middle-Aged and Elderly Men and Women With Impaired Fasting Glucose at Risk for a First Episode of Symptomatic Heart Failure Epidemiology
Conclusion Middle- and older-aged individuals with diabetes or impaired fasting glucose have higher stress measures of arterial stiffness than those with normal fasting glucose. These data emphasize the need for future studies with larger sample sizes to determine whether stress-related elevations in arterial stiffness are related to exercise intolerance and future episodes of heart failure experienced by those with abnormalities of fasting glucose. Clinical Trial Registration URL: http://clinicaltrials.gov/. Unique identifier: NCT00542503.
Source: JAHA:Journal of the American Heart Association - January 14, 2015 Category: Cardiology Authors: Vasu, S., Morgan, T. M., Kitzman, D. W., Bertoni, A., Stacey, R. B., Hamilton, C., Chiles, C., Thohan, V., Hundley, W. G. Tags: Epidemiology Source Type: research

Resistive and Pulsatile Arterial Hemodynamics and Cardiovascular Events: The Multiethnic Study of Atherosclerosis Heart Failure
Conclusions Greater total arterial compliance, manifest by higher stroke volume/pulse pressure is associated with a reduced incidence of subsequent CVE. In contrast, SVR was not independently associated with CVE in subjects free of overt cardiovascular disease at baseline. These findings support the concept that alternations in the large conduit vessels, rather than changes in microvascular resistance, are primarily related to incident cardiovascular disease.
Source: JAHA:Journal of the American Heart Association - December 11, 2014 Category: Cardiology Authors: Lilly, S. M., Jacobs, D., Bluemke, D. A., Duprez, D., Zamani, P., Chirinos, J. Tags: Heart Failure Source Type: research

Electrocardiographic Deep Terminal Negativity of the P Wave in V1 and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities (ARIC) Study Coronary Heart Disease
Conclusion DTNPV1 is predictive of SCD suggesting its potential utility in risk stratification in the general population.
Source: JAHA:Journal of the American Heart Association - November 21, 2014 Category: Cardiology Authors: Tereshchenko, L. G., Henrikson, C. A., Sotoodehnia, N., Arking, D. E., Agarwal, S. K., Siscovick, D. S., Post, W. S., Solomon, S. D., Coresh, J., Josephson, M. E., Soliman, E. Z. Tags: Coronary Heart Disease Source Type: research

Prognostic Value of Estimated Functional Capacity Incremental to Cardiac Biomarkers in Stable Cardiac Patients Coronary Heart Disease
Conclusion A simple self-assessment tool of functional capacity in stable patients undergoing elective diagnostic cardiac evaluation provides independent and incremental prognostic value for prediction of both significant coronary angiographic disease and long-term adverse clinical events.
Source: JAHA:Journal of the American Heart Association - October 20, 2014 Category: Cardiology Authors: Tang, W. H. W., Topol, E. J., Fan, Y., Wu, Y., Cho, L., Stevenson, C., Ellis, S. G., Hazen, S. L. Tags: Coronary Heart Disease Source Type: research

HIV Infection and Cardiovascular Disease in Women Epidemiology
Conclusions HIV is associated with an increased risk of CVD in women.
Source: JAHA:Journal of the American Heart Association - October 16, 2014 Category: Cardiology Authors: Womack, J. A., Chang, C.-C. H., So-Armah, K. A., Alcorn, C., Baker, J. V., Brown, S. T., Budoff, M., Butt, A. A., Gibert, C., Goetz, M. B., Gottdiener, J., Gottlieb, S., Justice, A. C., Leaf, D., McGinnis, K., Rimland, D., Rodriguez-Barradas, M. C., Sico, Tags: Epidemiology Source Type: research

Short-Term Change in eGFR and Risk of Cardiovascular Events Health Services and Outcomes Research
Conclusion Clinically relevant changes in eGFR are associated with increased risk of cardiovascular events. However, most of the apparent increase in risk can be accounted for by assessing comorbidity and baseline kidney function.
Source: JAHA:Journal of the American Heart Association - September 11, 2014 Category: Cardiology Authors: Turin, T. C., James, M. T., Jun, M., Tonelli, M., Coresh, J., Manns, B. J., Hemmelgarn, B. R. Tags: Health Services and Outcomes Research Source Type: research

Importance of Exercise Capacity in Predicting Outcomes and Determining Optimal Timing of Surgery in Significant Primary Mitral Regurgitation Valvular Heart Disease
Conclusion In patients with primary MR that underwent exercise echocardiography followed by MV surgery, lower achieved metabolic equivalents were associated with worse long-term outcomes. In those with preserved exercise capacity, delaying MV surgery by ≥1 year did not adversely affect outcomes.
Source: JAHA:Journal of the American Heart Association - September 11, 2014 Category: Cardiology Authors: Naji, P., Griffin, B. P., Barr, T., Asfahan, F., Gillinov, A. M., Grimm, R. A., Rodriguez, L. L., Mihaljevic, T., Stewart, W. J., Desai, M. Y. Tags: Valvular Heart Disease Source Type: research

Prognostic Implications of Left Ventricular Dyssynchrony for Major Adverse Cardiovascular Events in Asymptomatic Women and Men: The Multi-Ethnic Study of Atherosclerosis Heart Failure
Conclusions In an asymptomatic cohort, greater LV dyssynchrony determined by cardiac magnetic resonance imaging predicts adverse cardiovascular outcome in women but not in men. Clinical Trial Registration URL: http://clinicaltrials.gov. Unique identifier: NCT00005487.
Source: JAHA:Journal of the American Heart Association - August 4, 2014 Category: Cardiology Authors: Sharma, R. K., Volpe, G., Rosen, B. D., Ambale-Venkatesh, B., Donekal, S., Fernandes, V., Wu, C. O., Carr, J., Bluemke, D. A., Lima, J. A. C. Tags: Heart Failure Source Type: research

B-type Natriuretic Peptides for the Prediction of Cardiovascular Events in Patients With Stable Coronary Heart Disease: The Heart and Soul Study Coronary Heart Disease
Conclusions Both BNP and NT-proBNP were significant predictors of MACE in stable coronary heart disease; however, NT-proBNP was superior to BNP for net risk reclassification for MACE.
Source: JAHA:Journal of the American Heart Association - July 22, 2014 Category: Cardiology Authors: Mishra, R. K., Beatty, A. L., Jaganath, R., Regan, M., Wu, A. H. B., Whooley, M. A. Tags: Coronary Heart Disease Source Type: research

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