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Source: Journal of Stroke and Cerebrovascular Diseases
Therapy: Stem Cell Therapy
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Total 26 results found since Jan 2013.
Survival and Differentiation of Transplanted Neural Stem Cells Derived from Human Induced Pluripotent Stem Cells in A Rat Stroke Model
Conclusions: To our knowledge, this is the first report of transplantation of NSCs derived from human iPSCs in a stroke model. Human iPSC-derived NSCs survived in the postischemic rat brain and appeared to differentiate, primarily into neurons. This cell transplantation approach for stroke appears to be feasible, but further optimization is needed.
Source: Journal of Stroke and Cerebrovascular Diseases - November 14, 2011 Category: Neurology Authors: Matthew B. Jensen, Hongmei Yan, Rajeev Krishnaney-Davison, Abdullah Al Sawaf, Su-Chun Zhang Tags: Original Articles Source Type: research
Involvement of T-bet and GATA3 transcription factors in Mesenchymal stem cells and royal jelly combination treatment in brain stroke
Stroke as a common non-communicable disease can manifest itself as ischemic (87%) and hemorrhagic.1 However, the viable cells surrounding the infarct core have been shown to be at risk for infarct and apoptosis. Some therapeutic approaches are trying to improve neuronal recovery in the region and reduce post-stroke disability.2,3 Currently, to dissolve the clot and rescue the surrounding cells in the ischemic condition, tissue plasminogen activator (tPA) is administrated within the first three hours of the onset of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2022 Category: Neurology Authors: Mohammad Kazemi Arababadi, Mohammad Reza Rahmani, Fatemeh Asadi, Ahmad Shabanizadeh, Aliakbar Yousefi-Ahmadipour Source Type: research
Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2
Ischemic stroke is a frequently occurring cerebrovascular disease (CVD) linked to high mortality, disability, and incidence rates, and the second factor causing global mortality41,3. There are two common sources of embolism in ischamic strokes: large artery atherosclerosis and small artery atherosclerosis. Ischemic stroke can be treated clinically with thrombolytic therapy4. Although ischemic stroke is treatable, post-cerebral ischemia blood reperfusion frequently induces inflammation, oxidative stress (OS) or additional unfavorable events that may exacerbate brain injury20,24.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2023 Category: Neurology Authors: Yingju Wang, Hongping Chen, Xuehui Fan, Chen Xu, Meng Li, Hongxue Sun, Jihe Song, Feihong Jia, Wan Wei, Fangchao Jiang, Guozhong Li, Di Zhong Source Type: research
Reparative Therapy for Acute Ischemic Stroke with Allogeneic Mesenchymal Stem Cells from Adipose Tissue: A Safety Assessment
Few studies have evaluated the possible beneficial effect of the administration of stem cells in the early stages of stroke. Intravenous administration of allogeneic mesenchymal stem cells (MSCs) from adipose tissue in patients with acute stroke could be a safe therapy for promoting neurovascular unit repair, consequently supporting better functional recovery. We aim to assess the safety and efficacy of MSC administration and evaluate its potential as a treatment for cerebral protection and repair.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2014 Category: Neurology Authors: Exuperio Díez-Tejedor, María Gutiérrez-Fernández, Patricia Martínez-Sánchez, Berta Rodríguez-Frutos, Gerardo Ruiz-Ares, Manuel Lara Lara, Blanca Fuentes Gimeno Source Type: research
NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons
Developing new medicines is a complex process where understanding the reasons for both failure and success takes us forward. One gap in our understanding of most candidate stroke drugs before clinical trial is whether they have a protective effect on human tissues. NXY-059 is a spin-trap reagent hypothesized to have activity against the damaging oxidative biology which accompanies ischemic stroke. Re-examination of the preclinical in vivo dataset for this agent in the wake of the failed SAINT-II RCT highlighted the presence of a range of biases leading to overestimation of the magnitude of NXY-059's effects in laboratory animals.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2018 Category: Neurology Authors: Ana Antonic, Mirella Dottori, Malcolm R. Macleod, Geoffrey A. Donnan, David W. Howells Source Type: research
Mesenchymal Stem Cells: The Potential Therapeutic Cell Therapy to Reduce Brain Stroke Side Effects
Tissue plasminogen activator (tPA) is the gold standard treatment for ischemic stroke in the time window of 3-4.5 hours after the onset of symptoms. However, tPA administration is associated with inflammation and neurotoxic effects. Mesenchymal stem cells (MSC)-based therapy is emerging as a promising therapeutic strategy to control different inflammatory conditions. This project was designed to examine the protective role of MSC administration alone or in combination with royal jelly (RJ) five hours after stroke onset.
Source: Journal of Stroke and Cerebrovascular Diseases - February 23, 2021 Category: Neurology Authors: Ahmad Shabanizadeh, Mohammad Reza Rahmani, Aliakbar Yousefi-Ahmadipour, Fatemeh Asadi, Mohammad Kazemi Arababadi Source Type: research
Dental Pulp Stem Cell Therapy in Ischemic Stroke: A Meta-Analysis of Preclinical Studies
More preclinical research evidence has shown that dental pulp stem cells (DPSCs) transplantation is expected to promote the recovery of ischemic stroke (IS), but it still lacks an evidence-based analysis. The purpose of this study was to investigate the effects of DPSCs on neurological function and infarct size in Sprague-Dawley (SD) rats with middle cerebral artery embolization (MCAO).
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2022 Category: Neurology Authors: Hongxia Wang, Mengjiao Sun, Jing Sun, Panpan Gong, Ning Liu, Manxia Wang Source Type: research
Cerebral dopamine neurotrophic factor increases proliferation, Migration and differentiation of subventricular zone neuroblasts in photothrombotic stroke model of mouse
Cerebral ischemic stroke can induce the proliferation of subventricular zone (SVZ) neural stem cells (NSCs) in the adult brain. However, this reparative process is restricted because of NSCs ’ death shortly after injury or disability of them to reach the infarct boundary. In the present study, we investigated the ability of cerebral dopamine neurotrophic factor (CDNF) on the attraction of SVZ-resident NSCs toward the lesioned area and neurological recovery in a photothrombotic (PT) st roke model of mice
Source: Journal of Stroke and Cerebrovascular Diseases - September 15, 2022 Category: Neurology Authors: Zahra Shabani, Hamid Soltani Zangbar, Ava Nasrolahi Source Type: research
Short-term beneficial effects of human dental pulp stem cells and their secretome in a rat model of mild ischemic stroke
Although cell therapy has been applied in regenerative medicine for decades, recent years have seen greatly increased attention being given to the use of stem cell-based derivatives such as cell-free secretome. Dental pulp stem cells (DPSCs) are widely available, easily accessible, and have high neuroprotective and angiogenic properties. In addition, DPSC-derived secretome contains a rich mixture of trophic factors. The current investigation evaluated the short-term therapeutic effects of human DPSCs and their secretome in a rat model of mild ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - June 22, 2023 Category: Neurology Authors: Nahid Jashire Nezhad, Anahid Safari, Mohammad Reza Namavar, Mohammad Nami, Saeideh Karimi-Haghighi, Sareh Pandamooz, Mehdi Dianatpour, Negar Azarpira, Zahra Khodabandeh, Shahrokh Zare, Etrat Hooshmandi, Mahnaz Bayat, Maryam Owjfard, Seyedeh Shaghayegh Zaf Source Type: research
Evaluation of the Safety and Efficacy of the Therapeutic Potential of Adipose-Derived Stem Cells Injected in the Cerebral Ischemic Penumbra
Stroke represents an attractive target for cell therapy. Although different types of cells have been employed in animal models with variable results, the human adipose-derived stem cells (hASCs) have demonstrated favorable characteristics in the treatment of diseases with inflammatory substrate, but experience in their intracerebral administration is lacking. The purpose of this study is to evaluate the effect and safety of the intracerebral application of hASCs in a stroke model.
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2018 Category: Neurology Authors: Ulises G ómez-Pinedo, Leyre Sanchez-Rojas, María Soledad Benito-Martin, Cristina Lendinez, Gonzalo León-Espinosa, Fernando Rascón, Jone Herrero, Begoña Castro, Lidia Moreno-Jiménez, Maite del Olmo, Jordi A. Matias-Guiu, Jorge Matias-Guiu, Juan A. Ba Source Type: research
Neuroprotective Effects of and -Modified Bone Mesenchymal Stem Cells in Focal Cerebral Ischemia in Rats
Administration of bone marrow stromal cells (BMSCs) has been reported to ameliorate functional deficits in rat ischemia models. In the present study, we tried to reveal the underlying mechanism of the improvement of neurological function after stroke by BMSCs transfected with brain-derived neurotrophic factor (BDNF) and/or Noggin.
Source: Journal of Stroke and Cerebrovascular Diseases - November 30, 2015 Category: Neurology Authors: Hongyan Lu, Xingmiao Liu, Nan Zhang, Xiaodong Zhu, Hao Liang, Li Sun, Yan Cheng Source Type: research
A Combined Approach to Intracerebral Hemorrhage: Intravenous Mesenchymal Stem Cell Therapy with Minimally Invasive Hematoma Evacuation
We report the first case of a patient with intracerebral hemorrhage (ICH) treated with combination MSC therapy and endoscopic hematoma evacuation.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Kaneez Zahra, Marion T. Turnbull, Abba C. Zubair, Jason L. Siegel, Carla P. Venegas-Borsellino, Rabih G. Tawk, William D. Freeman Tags: Case Report Source Type: research
The Effect of Umbilical Cord Mesenchymal Stem Cells Combined with Tetramethylpyrazine Therapy on Ischemic Brain Injury: A Histological Study
Relatively poor survival and differentiation performance of umbilical cord mesenchymal stem cells (ucMSCs) limits its application of transplantation. The purpose of this study was to investigate the combined effect of ucMSCs and tetramethylpyrazine (TMP) on the histological therapy of ischemia stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - September 16, 2020 Category: Neurology Authors: Huiling Cao, Yingying Cheng, Jie Zhang, Min Xu, Liang Ge Source Type: research
Corrigendum to ’ Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha’ Journal of Stroke and Cerebrovascular Diseases 31/2 (2022) 106221
The authors regret
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2022 Category: Neurology Authors: Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, LuKui Chen Tags: Corrigendum Source Type: research
