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Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats
Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic agent recombinant tissue plasminogen activator. α1-Antitrypsin (AAT), a serine proteinase inhibitor with potent anti-inflammatory, anti-apoptotic, antimicrobial, and cytoprotective activities, could be beneficial in stroke. The goal of this study is to test whether AAT can improve ischemic stroke outcome in an established rat model. Middle cerebral artery occlusion was induced in male rats via intracranial (i.c.) microinjection of endothelin-1. Five to 10 minutes after...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Huong L. Moldthan, Aaron C. Hirko, Jeffrey S. Thinschmidt, Maria B. Grant, Zhimin Li, Joanna Peris, Yuanqing Lu, Ahmed S. Elshikha, Michael A. King, Jeffrey A. Hughes, Sihong Song Tags: Original Articles Source Type: research

Neurogenic cardiac outcome in patients after acute ischemic stroke: The brain and heart connection
This study aims to identify the association between cardiac outcomes and middle cerebral artery (MCA) ischemic stroke, with or without insular cortex involvement, as well as the impact of new-onset atrial fibrillation (AF) after AIS on recurrent stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 28, 2022 Category: Neurology Authors: Jiangyong Min, Grant Young, Abdullah Umar, Andrew Kampfschulte, Asad Ahrar, Malgorzata Miller, Nadeem Khan, Nabil Wees, Nagib Chalfoun, Muhib Khan Tags: Review Article Source Type: research

Computational Image Analysis of Nonenhanced Computed Tomography for Acute Ischaemic Stroke: A Systematic Review
Noncontrast enhanced computed tomography (NCCT) remains the most common method for brain imaging patients who present acutely with ischaemic stroke. Computational methods may improve NCCT analysis in this context. We systematically reviewed current research.
Source: Journal of Stroke and Cerebrovascular Diseases - March 2, 2020 Category: Neurology Authors: Paul Mikhail, Michael Gia Duy Le, Grant Mair Source Type: research

Corrigendum to ‘Predictive value of the combination between the intracranial arterial culprit plaque characteristics and the Essen Stroke Risk Score for short-term stroke recurrence’ Journal of Stroke and Cerebrovascular Diseases Volume 31, Issue 9, September 2022, 106624
This study was funded by grants from the Nantong Municipal Science and Technology Plan Project (Nos. MS12020041, MS12021101, HS2019002) and Nantong Municipal Health Commission Youth Project (No. MB2020001).
Source: Journal of Stroke and Cerebrovascular Diseases - October 13, 2022 Category: Neurology Authors: Kaixuan Ren, Huayun Jiang, Tiantian Li, Chengqun Qian, Shenchu Gong, Tianle Wang, Li Zhu Tags: Corrigendum Source Type: research

Corrigendum to ‘Should IV Thrombolysis be given in Patients with Suspected Ischemic Stroke but Unknown Symptom Onset and Without Diffusion-Weighted Imaging Lesion? - Results of a Case-Control Study’ Journal of Stroke and Cerebrovascular Diseases, Vol. 29, No. 2 (February), 2020: 104515
The authors regret that there were two instances of inaccuracies in the published article. The name of a co-author was misspelled and should correctly be Prof. Karl Georg Haeusler. Furthermore the following must also be stated as a conflict of interest: KGH reports study grants by Bayer and Sanofi-Aventis, lecture fees / advisory board fees from Sanofi-Aventis, Pfizer, Bristol-Myers-Squibb, Boehringer Ingelheim, Daiichi Sankyo, Biotronik, WL Gore& Associates and Medtronic. The authors would like to apologise for any inconvenience caused.
Source: Journal of Stroke and Cerebrovascular Diseases - March 11, 2020 Category: Neurology Authors: Mert Seyhan, Daniel Mackenrodt, Ignaz Gunreben, Wolfgang M üllges, Karl Georg Haeusler, Mirko Pham, Christoph Kleinschnitz, Peter Kraft Tags: Corrigendum Source Type: research

Cerebral White Matter Hypoperfusion Increases with Small-Vessel Disease Burden. Data From the Third International Stroke Trial
Leukoaraiosis is associated with impaired cerebral perfusion, but the effect of individual and combined small-vessel disease (SVD) features on white matter perfusion is unclear.
Source: Journal of Stroke and Cerebrovascular Diseases - March 14, 2017 Category: Neurology Authors: Francesco Arba, Grant Mair, Trevor Carpenter, Eleni Sakka, Peter A.G. Sandercock, Richard I. Lindley, Domenico Inzitari, Joanna M. Wardlaw, IST-3 Trial Collaborators Source Type: research

Telestroke Consultation in the Emergency Medical Services Unit: A Novel Approach to Improve Thrombolysis Times
Faster treatment times are associated with improved outcomes in patients with acute ischemic stroke. In this prospective pilot study, we assess the feasibility of initiating telestroke consultation in emergency medical services unit (TEMS).
Source: Journal of Stroke and Cerebrovascular Diseases - March 6, 2021 Category: Neurology Authors: Sami Al Kasab, Eyad Almallouhi, Cheryl Grant, Dale Hewitt, Jessica Hewitt, Morgan Baki, Perette Sabatino, David Jones, Christine A. Holmstedt Source Type: research

Erratum
In the article “The impact factors on the cost and length of stay among acute ischemic stroke” by Huang YC et al. in the October 2013 issue (2013;22(7):e152-8; doi:10.1016/j.jstrokecerebrovasdis.2012.10.014), the wrong study period was listed in the Abstract and Methods section of the article. Grant support also needed to be acknowledged. The corrected lines appear below. The authors regret the errors.
Source: Journal of Stroke and Cerebrovascular Diseases - September 26, 2014 Category: Neurology Tags: Erratum Source Type: research

Beating the Clock: Time Delays to Thrombolytic Therapy with Advanced Imaging and Impact of Optimized Workflow
This study is to assess the time delay while using this scanner compared with our 64-slice scanner.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2015 Category: Neurology Authors: Santanu Chakraborty, James Ross, Mathew J. Hogan, Dar Dowlatshahi, Grant Stotts Source Type: research

Asymmetric cerebral edema presenting with severe neurologic impairment and seizures after cardiac and thoracic interventions
A syndrome of focal neurologic deficits with characteristic imaging features, acute encephalopathy, and seizures after cardiac and thoracic interventions has been previously briefly reported in the literature. In a retrospective observational study, we aim to identify the prevalence and characteristics of this syndrome, in addition to discussing the possible underlying pathophysiology.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Ibrahim Migdady, Alexander Rae-Grant Source Type: research

Cerebral Microhemorrhage and Purpuric Rash in COVID-19: The Case for a Secondary Microangiopathy
We report the case of a COVID-19 patient with diffuse microhemorrhages on brain MRI, positive anticardiolipin antibodies, and purpuric rash with biopsy showing a thrombotic vasculopathy, all features suggestive of secondary microangiopathy.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Aaron Shoskes, Ibrahim Migdady, Anthony Fernandez, Paul Ruggieri, Alexander Rae-Grant Tags: Case Report Source Type: research