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Preventive Treatment with Lomerizine Increases Cerebral Blood Flows during the Interictal Phase of Migraine
We examined rCBF after lomerizine treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2017 Category: Neurology Authors: Ken Ikeda, Joe Aoyagi, Sayori Hanashiro, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Yuichi Ishikawa, Ken Miura, Kiyoko Murata, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki Source Type: research

Evaluation of Intraplaque Neovascularization Using Superb Microvascular Imaging and Contrast-Enhanced Ultrasonography
Several studies have shown a linkage between intraplaque neovascularization (IPN) and plaque instability. Although contrast-enhanced ultrasonography (CEUS) may help visualize IPN in the carotid artery, its benefits are limited in Japan, where there is no health insurance coverage for contrast agents in medical imaging. Superb microvascular imaging (SMI), however, enables the depiction of low-velocity blood flow. The current study compares the diagnostic accuracy of SMI and CEUS in the evaluation of IPN.
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2018 Category: Neurology Authors: Kazumasa Oura, Tadayoshi Kato, Hideki Ohba, Yasuo Terayama Source Type: research

Rectus Sheath Hematoma Following Intravenous Thrombolysis With Recombinant Tissue Plasminogen Activator for Cerebral Infarction: A Case Report
A 76-year-old Japanese man was admitted to our department because of aphasia and right hemiparesis. Brain magnetic resonance imaging showed cerebral infarction caused by occlusion of the left middle cerebral artery, and alteplase therapy was started. Thrombectomy was subsequently performed, resulting in recanalization. On day 4 after admission, he complained of epigastric pain when coughing. On day 8, contrast-enhanced computed tomography showed a left abdominal rectus sheath hematoma without extravasation.
Source: Journal of Stroke and Cerebrovascular Diseases - August 16, 2018 Category: Neurology Authors: Tatsuya Ueno, Takashi Nakamura, Hiroki Hikichi, Akira Arai, Chieko Suzuki, Masahiko Tomiyama Tags: Case Report Source Type: research

Trends of Antiplatelet Therapy for the Management of Moyamoya Disease in Japan: Results of a Nationwide Survey
This study reports results of a nationwide survey conducted in 2016 on the trends of antiplatelet therapy for moyamoya disease in Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - September 14, 2018 Category: Neurology Authors: Koichi Oki, Masahiro Katsumata, Yoshikane Izawa, Shinichi Takahashi, Norihiro Suzuki, Kiyohiro Houkin, Research Committee on Spontaneous Occlusion of Circle of Willis (Moyamoya disease) Source Type: research

Risk Factors for Hemorrhagic and Cardioembolic Complications of Intracerebral Hemorrhage Associated with Anticoagulants
This study investigated hemorrhagic and cardioembolic events and risk factors in intracerebral hemorrhage patients taking anticoagulants. Methods: The clinical data of 65 consecutive intracerebral hemorrhage patients taking anticoagulants were retrospectively reviewed.
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2018 Category: Neurology Authors: Sho Osawa, Tatsuya Shimizu, Tadashige Kano, Ryosuke Shintoku, Hiroya Fujimaki, Ken Asakura Source Type: research

The CADASIL Scale-J, A Modified Scale to Prioritize Access to Genetic Testing for Japanese CADASIL-Suspected Patients
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is definitely diagnosed by genetic testing. Such testing involves the analysis of exons 2-24 of NOTCH3, which encode the epidermal growth factor-like repeat domain, where CADASIL mutations are localized. We previously reported clinical diagnostic criteria for screening CADASIL-suspected Japanese patients prior to genetic testing. Because of its high sensitivity but low specificity, most patients need to undergo genetic testing.
Source: Journal of Stroke and Cerebrovascular Diseases - April 3, 2019 Category: Neurology Authors: Takashi Koizumi, Ikuko Mizuta, Akiko Watanabe-Hosomi, Mao Mukai, Ai Hamano, Jun Matsuura, Tomoyuki Ohara, Toshiki Mizuno Source Type: research

Helicopter Transport for Patients with Cerebral Infarction in Rural Japan
In this study, we evaluated the relationship between helicopter transport and the prognosis of patients with acute cerebral infarction in rural Japan. Methods: This retrospective, observational study included 546 patients with acute cerebral infarction attending Aomori Prefectural Central Hospital, which serves a rural region of Japan. Patients were separated into 2 transport groups: physician-staffed helicopter emergency medical services and ground emergency medical services.
Source: Journal of Stroke and Cerebrovascular Diseases - June 26, 2019 Category: Neurology Authors: Tatsuya Ueno, Haruo Nishijima, Hiroki Hikichi, Rie Haga, Akira Arai, Chieko Suzuki, Jin-ichi Nunomura, Kyoji Saito, Masahiko Tomiyama Source Type: research

Imaging Classification of Internal Carotid Artery Hypoplasia Based on Distal Ophthalmic Segment Occlusion
Background: Internal carotid artery (ICA) hypoplasia (ICAH) is rare. The classification of ICAH is largely unclear. The aim of the study is to propose a new imaging classification for ICAH based on the occlusion of the distal ophthalmic segment and discuss the clinical and radiological differences between the different types. Materials and Methods: This was a retrospective study of patients with congenital ICAH diagnosed at the Department of Neurology of the China-Japan Friendship Hospital between June 2011 and June 2016.
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2019 Category: Neurology Authors: Zhiyong Zhang, Zhiqin Liu, Zunjing Liu Source Type: research

A Case of Leukoencephalopathy and Small Vessels Disease Caused by a Novel HTRA1 Homozygous Mutation
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a heritable, rare small vessel disease, which is caused by HTRA1 mutations and mostly reported Japanese and Chinese population. CARASIL is an orphan disease, which presents with progressive motor and cognitive impairment, alopecia, and spondylosis. The disease typically starts with lumbago at early twenties. Ischemic strokes start at mid-twenties. Patients have no cardiovascular or any other risk factors.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2019 Category: Neurology Authors: Tuncay G ündüz, Yasemin Demirkol, Özlem Doğan, Serkan Demir, Nihan Hande Akçakaya Source Type: research

Cerebral Infarction after Transcatheter Aortic Valve Implantation in Japan: Retrospective Analysis at a Single High-Volume Center
Perioperative cerebral infarction is one of the concerning complications after transcatheter aortic valve implantation in patients with aortic stenosis. Several studies have reported on this complication; however, those included only Caucasians and analyzed a small number of cases. Here, we report on the characteristics and risk factors of symptomatic cerebral infarction after transcatheter aortic valve implantation in a single, high-volume center in Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2019 Category: Neurology Authors: Takashi Iizuka, Koichi Oki, Kentaro Hayashida, Kazushi Minami, Yoshikane Izawa, Shinichi Takahashi, Hideyuki Shimizu, Keiichi Fukuda, Jin Nakahara Source Type: research

Can Moyamoya Disease Susceptibility Gene Affect Extracranial Systemic Artery Stenosis?
We report a case of a unique Japanese pedigree associated with RNF213. A 53-year-old woman with no arteriosclerotic risk factors experienced coronary artery disease, followed by coronary artery bypass surgery. In 8 years, she suffered sudden abdominal pain.
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2019 Category: Neurology Authors: Shunsuke Nomura, Yasuo Aihara, Hiroyuki Akagawa, Kentaro Chiba, Koji Yamaguchi, Akitsugu Kawashima, Yoshikazu Okada, Takakazu Kawamata Source Type: research

Hypoglossal Nerve Palsy due to Compression by a Persistent Primitive Hypoglossal Artery: Case Report
A 51-year-old Japanese woman was admitted to our hospital because of speech difficulty following severe headache. Neurological examination showed dysarthria and tongue weakness on the right side, indicating right hypoglossal nerve palsy. Needle electromyography of the right side of the tongue showed fibrillation potentials. Magnetic resonance angiography and computed tomography angiography revealed a right, persistent, primitive hypoglossal artery (PPHA) that met Lie's diagnostic criteria. Digital subtraction angiography showed an extended PPHA with irregular caliber in the portion running through the right hypoglossal canal.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2019 Category: Neurology Authors: Hiroki Hikichi, Tatsuya Ueno, Masatoshi Iwamura, Haruo Nishijima, Akira Arai, Chieko Suzuki, Hiroshi Midorikawa, Jin-ichi Nunomura, Masahiko Tomiyama Tags: Case Report Source Type: research

Outcomes in Elderly Japanese Patients Treated for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Nationwide Study
Objective: Japan has the largest elderly population in the world. As data on the clinical outcomes in elderly patients with aneurysmal subarachnoid hemorrhage (aSAH), including those older than 80 years, are lacking, we analyzed the characteristics of 54,805 aSAH patients and recorded their treatments and clinical outcomes using a Japanese nationwide inpatient database. Methods: Using the Japanese Diagnostic Procedure Combination database, we identified aSAH patients aged 18 years or older who were hospitalized between July 1, 2010 and March 31, 2016.
Source: Journal of Stroke and Cerebrovascular Diseases - March 24, 2020 Category: Neurology Authors: Kohei Hironaka, Shotaro Aso, Masanori Suzuki, Fumihiro Matano, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Akio Morita Source Type: research

Recurrent Cerebral Venous Thrombosis Treated with Direct Oral Anticoagulants in a Japanese Man with Hereditary Protein C Deficiency
We herein report a case involving a 32-year-old Japanese man with recurrent cerebral venous thrombosis due to hereditary protein C deficiency. He was admitted to our hospital with impaired consciousness. Brain magnetic resonance imaging demonstrated high intensities diffusely along the bilateral sulci and magnetic resonance venography revealed left transverse sinus and superior sagittal sinus stenoses. His father had a history of cerebral infarction and venous thrombosis. The protein C activity level examined by chromogenic synthetic substrate assay was markedly reduced.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Kazuyuki Saito, Kazuyuki Ishii, Konosuke Furuta, Masaki Kobayashi, Yoshiaki Wada, Eriko Morishita Tags: Case Report Source Type: research

Reliability of the Modified Rankin Scale Assessment Using a Simplified Questionnaire in Japanese
We developed a Japanese version of the simplified modified Rankin Scale questionnaire, of which the agreement between patients or their family members and neurologists was verified in a previous single-center study. In the present study, the reliability of the questionnaire was evaluated in another hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2020 Category: Neurology Authors: Kenichiro Yi, Yuichiro Inatomi, Makoto Nakajima, Toshiro Yonehara, Mitsuharu Ueda Source Type: research

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