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Progressive thrombosis of cervical and intracranial arteries related to Ponatinib treatment for Chronic Myeloid Leukemia
Ponatinib is a third-generation Tyrosine Kinase Inhibitor (TKI), approved as first-line treatment for Chronic Myeloid Leukaemia (CML) chronic phase.Here we describe a CML patient with a history of subsequent TIAs and an ischemic stroke during Ponatinib treatment. Patient was admitted for a 3-day history of sudden onset left hemiparesis due to an acute ischemic stroke. MRI showed bilaterally the almost total absence of signal in the intracranial tract of anterior circulation and low signal of cerebral posterior circulation.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: E Spina, R Renna, LA Lanterna, ML Colleoni, V Andreone Tags: Case Report Source Type: research

Nilotinib-Associated Atherosclerosis Presenting as Multifocal Intracranial Stenosis and Acute Stroke
Nilotinib is considered an effective and well-tolerated frontline agent used in the treatment of chronic myelogenous leukemia (CML). It is a breakpoint cluster region-Ableson (BCR-ABL) tyrosine kinase inhibitor (TKI) that has been associated with accelerated arterial stenosis, presumably of atherosclerotic etiology. However, reports are mostly limited to peripheral artery occlusive disease (PAOD), specifically in the lower extremities.1 The mechanism by which it promotes atherosclerosis is poorly understood but endothelial and perivascular factors, mast cell depletion, and metabolic factors such as promotion of dyslipidemi...
Source: Journal of Stroke and Cerebrovascular Diseases - June 2, 2021 Category: Neurology Authors: Bhavika Kakadia, Richa Thakkar, Emma Sanborn, Giselle Alexandra Suero-Abreu, Tudor G. Jovin, Ryna Then Tags: Case Report Source Type: research

Rapidly Progressive Intracranial Vasculopathy in Graft Versus Host Disease
We report a previously undescribed noninflammatory vasculopathy causing multifocal intracranial arterial occlusions and cerebral infarctions in a man following allogenic hematopoietic stem cell transplantation for chronic lymphocytic leukemia, which we propose to be a central nervous system manifestation of graft versus host disease.
Source: Journal of Stroke and Cerebrovascular Diseases - March 12, 2019 Category: Neurology Authors: Theodore Bowen, Shawn A. Silver, Cathy Sila Tags: Case Report Source Type: research