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Calcium Channel Subunit α2δ-1 as a Potential Biomarker Reflecting Illness Severity and Neuroinflammation in Patients with Acute Ischemic Stroke
Cerebral infarction (commonly known as ischemic stroke) is a leading cause of morbidity, mortality and disability worldwide. Activation of presynaptic voltage-gated calcium channels (VGCCs) and glutamate release plays a central role in neuronal necrosis after cerebral ischemia.1,2 Previous studies seemed to be encouraging that nimodipine, a dihydropyridine calcium channel antagonist, had a significant benefit in mortality and neurologic outcome in patients with mild stroke or within 12 hours of stroke, although there was still controversial.
Source: Journal of Stroke and Cerebrovascular Diseases - May 25, 2021 Category: Neurology Authors: Xiaoqin Xiong, Linjing Zhang, Yunhui Li, Shuang Guo, Wei Chen, Lijun Huang, Yi Luo Source Type: research

Carotid Calcium Volume and Stenosis after Stent Implantation
Internal carotid artery (ICA) stenosis could be treated with stent placement. It was hypothesized that calcium amount could be predictive of vessel stenosis after stent placement. We utilised computed tomography (CT) angiography to quantify volume of calcium material in bulbar ICA.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Johannes Sebastian Mutzenbach, Lukas Machegger, Luis Rafael Moscote-Salazar, Monika Killer-Oberpfalzer, Erasmia M üller-Thies-Broussalis, Slaven Pikija Source Type: research

miR-134-5p inhibition reduces infarct-induced cardiomyocyte apoptosis via Creb1 upregulation
Patients presenting with symptoms related to acute coronary syndrome account for a total of 5% to 10% of all visits to the emergency department.1,2 However, the ability to accurately diagnose and treat patients that present with acute myocardial infarction (AMI) is often challenging and time-consuming. Following AMI-induced ischemia, many pathological changes occur to the cardiomyocytes, including reactive oxygen species (ROS) overload, calcium dyshomeostasis, metabolic dysfunction, and cell death.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Jibin Yang, Shiwen Liu, Hao Wang, Ying Liu, Yong Liu Source Type: research

The Relation of Calcium Volume Score and Stenosis of Carotid Artery
The aim of this study was to investigate the value of extracranial carotid artery calcium score in predicting severity of carotid arterial stenosis.
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2019 Category: Neurology Authors: Maryam Moradi, Mohammad Mehdi Baradaran Mahdavi, Mehdi Karami Nogourani Source Type: research

Intracranial Artery Calcium Burden Predicts Recurrent Cerebrovascular Events in Transient Ischaemic Attack Patients
Background: Patients with initial transient ischaemic attack (TIA) subsequently have a higher risk of recurrent TIA or acute ischemic stroke (AIS). The role of scoring intracranial arterial calcification (IAC) in predicting the prevalence of stroke remains unclear. We aim to evaluate if radiological CT calcium score measuring IAC burden could predict future ischemic events in a cohort of TIA patients. Methods: We studied consecutive patients from July 2014 to December 2015 who presented with first episode of TIA.
Source: Journal of Stroke and Cerebrovascular Diseases - June 13, 2019 Category: Neurology Authors: Wan Yee Kong, Benjamin YQ Tan, Eide Sterling Ellis, Nicholas JH Ngiam, Wilson GW Goh, Vijay K Sharma, Bernard PL Chan, Leonard LL Yeo Source Type: research

Factors Influencing Quality of Life in Stroke Patients: Focus on Eating Habits
This study aimed to identify lifestyle factors about eating habits that may affect the quality of life (QOL) in elderly stroke patients. Methods: Fifty elderly patients with a first-ever stroke were enrolled. QOL was assessed by the Stroke and Aphasia QOL Scale-39-J. Lifestyle factors about eating habits were collected using questionnaires (Questions 1-17) for the intake of salt, calcium, magnesium, potassium, taurine, fiber, and protein, and the frequency of breakfast.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2019 Category: Neurology Authors: Reina Chiba, Saya Tominaga, Kasumi Mikami, Maiko Kitajima, Mayumi Urushizaka, Toshiko Tomisawa, Junko Chiba, Joji Hagii, Minoru Yasujima, Tomohiro Osanai Source Type: research

Preventive Treatment with Lomerizine Increases Cerebral Blood Flows during the Interictal Phase of Migraine
We examined rCBF after lomerizine treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2017 Category: Neurology Authors: Ken Ikeda, Joe Aoyagi, Sayori Hanashiro, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Yuichi Ishikawa, Ken Miura, Kiyoko Murata, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki Source Type: research