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Gap between recognition and response to stroke scenarios among Saudi population: Cross-sectional survey study
The objective of this study is to assess the presence of a gap in the Saudi population between the recognition of stroke symptoms and the appropriate response to call EMS.
Source: Journal of Stroke and Cerebrovascular Diseases - July 23, 2023 Category: Neurology Authors: Majed Mohammad Al-Hayani, Razan Ahmad Aljudibi, Yasser Alatawi, Badrah Saeed Alghamdi Source Type: research

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL): A challenging diagnosis and a rare multiple sclerosis mimic
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is an extremely rare hereditary cerebral small vessel disease caused by homozygous or compound heterozygous mutations in the gene coding for high-temperature requirement A serine peptidase 1 (HtrA1). Given the rare nature of the disease, delays in diagnosis and misdiagnosis are not uncommon. In this article, we reported the first case of CARASIL from Saudi Arabia with a novel homozygous variant c.1156C>T in exon 7 of the HTRA1 gene.
Source: Journal of Stroke and Cerebrovascular Diseases - June 20, 2023 Category: Neurology Authors: Bader Shirah, Hussein Algahtani, Raghad Algahtani, Ahmed Alfares, Ahmed Hassan Tags: Case Report Source Type: research

Corrigendum to ‘Health Behaviors among Stroke Survivors in the United States: A Propensity Score-Matched Study’ Journal of Stroke & Cerebrovascular Diseases, Vol. 27, No. 8 (August), 2018: pp 2124 –2133
The authors regret to inform the readers that there was an unnoticed mistake in the paper. An affiliation of Dr. Wali was not listed at the time of publication due to an oversight from the author. The aforementioned missing affiliation is the following: Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Source: Journal of Stroke and Cerebrovascular Diseases - February 9, 2021 Category: Neurology Authors: Haytham Wali, Sawsan Kurdi, Jawad Bilal, Irbaz Bin Riaz, Sandipan Bhattacharjee Tags: Corrigendum Source Type: research

Anterior circulation large vessel occlusion stroke in Saudi Arabia: Prevalence, predictors, and outcome
Anterior circulation Large Vessel Occlusion (LVO) stroke comes with significant morbidity and mortality. With the advent of endovascular interventions, its management has revolutionized. For health authorities to build systems and allocate resources, its burden, predictors, and outcome must be determined.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Ali M. Al Khathaami, Mohammed A. Aldriweesh, Bayan A. Al Bdah, Muath A. Alhasson, Sultan A. Alsaif, Waleed A. Alluhidan, Faisal M. Almutairi, Mohammed A. Alskaini, Nasser Alotaibi, Saeed A.M. Alghamdi Source Type: research

Stroke literacy in the population of the Eastern Province of Saudi Arabia; immediate steps are essential to bridge the gap
Stroke is one of the core non-communicable diseases (NCDs), which is preventable and demands appropriate preventive measures for reducing disease burden.1 Stroke has become the major challenge to health care system in Saudi Arabia (SA). According to the World Health Organization (WHO), stroke was the second commonest cause of death after coronary artery disease with deaths reaching 11, 409, or 11.7% of total deaths. The age adjusted deaths rate was 89.82 per 100,000 population.2 A recently published study reported an incidence rate for the first-time ever stroke as 57.64 per 100,000 person-years.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Azra Zafar, Aishah Ibrahim Albakr, Rizwana Shahid, Saima Nazish, Danah Aljaafari, Fahd Ali Alkhamis, Ahmed Abdulfattah Aldajani, Amir H. Msmar, Ismail A. Khatri Source Type: research

A Novel Heterozygous Variant in Exon 19 of NOTCH3 in a Saudi Family with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL; OMIM #125310) is the most common cause of monogenic familial cerebral small vessel disease. It typically manifests at middle adulthood with highly variable clinical features including migraine with aura, recurrent transient ischemic attacks or ischemic strokes, mood disorders, and progressive cognitive decline. It is caused by mutations in the NOTCH3 gene, which maps to the short arm of chromosome 19 and encode for epidermal growth factor-like repeats.
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Hussein Algahtani, Bader Shirah, Suzan Y. Alharbi, Mohammad H. Al-Qahtani, Angham Abdulrahman Abdulkareem, Muhammad Imran Naseer Tags: Case Report Source Type: research

Utilization of Intravenous Tissue Plasminogen Activator and Reasons for Nonuse in Acute Ischemic Stroke in Saudi Arabia
Background: Recombinant tissue plasminogen activator (rt-PA, alteplase) within 4.5 hours of symptom onset decreases the rate of disability after acute ischemic stroke (AIS). Due to various reasons, alteplase remains underutilized in certain regions ( ∼3% in low- and middle-income countries). Aims: We aimed to estimate the alteplase utilization rate and identify the reasons for nonuse in Saudi Arabia. Methods: We retrospectively reviewed all patients admitted with suspected stroke in the past 24 hours to the stroke unit at King Abdulaziz Medica l City, Riyadh, Saudi Arabia from February 2016 to July 2018.
Source: Journal of Stroke and Cerebrovascular Diseases - March 11, 2020 Category: Neurology Authors: Ali M. Al Khathaami, Bayan Al Bdah, Maisoun Tarawneh, Mohammed Alskaini, Faris Alotaibi, Abdulaziz Alshalan, Mohammed Almuhraj, Daham Aldaham, Nasser Alotaibi Source Type: research

An Epidemiological Model for First Stroke in Saudi Arabia
The Kingdom of Saudi Arabia has a young but ageing population, leading to concerns for planning for future growth in the number of strokes to provide necessary care. An understanding of the expected evolution of stroke incidence is therefore necessary to plan infrastructure changes. Our aim was to predict the number of first strokes occurring in Saudi Arabia over a 10-year period.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2019 Category: Neurology Authors: Fahmi Al-Senani, Mohamed Al-Johani, Mohammad Salawati, Adel Alhazzani, Lewis B. Morgenstern, Valeska Seguel Ravest, Matthieu Cuche, Simon Eggington Source Type: research

Embolic Stroke of Undetermined Source in Saudi Arabia: Prevalence, Patient Characteristics, and Outcomes
Background: Embolic stroke of undetermined source (ESUS) is a newly introduced clinical construct to better characterize cryptogenic stroke. It is associated with considerable morbidity and mortality and a high recurrence rate. It has not previously been investigated in Saudi stroke patients. We aimed to conduct a descriptive analysis of ESUS in Saudi Arabia, including its frequency among patients with acute stroke, characteristics, and outcomes. Methods: We reviewed all ischemic stroke patients admitted to the stroke unit at King Abdulaziz Medical City-Riyadh, Saudi Arabia, from February 2016 to July 2018.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2019 Category: Neurology Authors: Ali M. Al Khathaami, Bayan Al Bdah, Abdulmjeed Alnosair, Rayan Alrebdi, Shorug Alwayili, Sulaiman Alhamzah, Abdulkarim Al Turki, Nasser Alotaibi Source Type: research