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P 67 Electrophysiological correlates of language improvements after intensive language therapy in patients with chronic post-stroke aphasia
Aphasia affects approximately one third of all stroke patients and may lead to chronic disability. Effective neurorehabilitation programs focusing on improving speech and language in patients with post-stroke aphasia are essential. A better understanding of the neurobiological processes accompanying language deficits and rehabilitation may bear fruit in the advancement of neurorehabilitation programs.
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: G. Lucchese, F. Pulverm üller, B. Stahl, F. Dreyer, B. Mohr Tags: Poster Source Type: research

FV 13 Electrophysiological correlates of language recovery – an MEG study of neuroplasticity in chronic post stroke aphasia
Previous studies have demonstrated that efficient language and communication therapy in chronic post stroke aphasia leads to significant clinical language improvements (Pulverm üller et al., 2001) and promotes neuroplasticity. Brain areas frequently associated with functional restitution of language comprise perilesional sites in the left hemisphere (MacGregor et al., 2015) as well as right-hemispheric regions, homotopic to those lesioned in the left (Mohr et al., 2014). To date, however, the neuronal mechanisms underlying therapy-induced language changes and functional restitution are still largely unclear.
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: B. Mohr, S. Difrancesco, L. MacGregor, Y. Shtyrov Tags: Free Lecture Source Type: research

P 165 Incidence, clinical characteristics and longterm course of headache in patients with stroke (DMKG multicenter study)
Post stroke headache is a symptom which is generally not further differentiated. According to previous European and American studies, it is a common phenomenon. Nevertheless, other symptoms of stroke, such as palsy or aphasia, are dominating clinical assessments. However, the symptom “headache” can be an essential part of the clinical picture as in subarachnoid bleeding or cerebral venous thrombosis and it is unclear which risk factors modulate the symptoms and the occurrence of headache in stroke.
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: S. Dietrich, A. D üring, D. Rothkirch, F. Filippopulos, O. Eren, T. Dresler, T. Buchwald, A. Straube, S. Zierz, G. Goßrau, T. Kraya Tags: Poster Source Type: research

P 145 Deficient body structural description in apraxia
Apraxia is a common cognitive deficit after left hemisphere (LH) stroke. It has been suggested that a disturbed representation of the human body underlies apraxic deficits. Thus, we here tested the hypothesis that a deficient body structural description (BSD), i.e., a deficient representation of a body part ”s position (relative to a standard human body), contributes to apraxia, while controlling for a deficient semantic representation of the human body (body image, BI) and aphasia.A quantitative pointing task to assess putative BSD deficits and an apraxia assessment including imitation and pantomime tasks were applied t...
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: H. Salimi Dafsari, A. Dovern, G.R. Fink, P.H. Weiss Tags: Poster Source Type: research

EP 6. Longitudinal resting state functional connectivity patterns in the early phase of recovery from Aphasia in temporoparietal stroke
Poststroke aphasia recovery evolves in space and time. Substantial language improvements can be observed within the first days after stroke. However, underlying changes in the functional status of the language network during the acute phase remain to be demonstrated.
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: J. Klingbeil, A. Stockert, M. Wawrzyniak, K. Wrede, D. Saur Source Type: research

EP 3. Impact of energy expenditure and cognitive function on long- term outcome after stroke
Stroke leads to lesion-induced deficits like hemiparesis and aphasia. Furthermore patients suffer from low aerobic endurance and high energy expenditure of walking as well as from cognitive decline. Motor and Activity of daily living (ADL) rehabilitation might be negatively impacted by these factors. Here, our aim was to evaluate how (a) energy expenditure of walking and (b) cognitive function in the subacute phase after stroke correlate to long-term outcomes (gait speed, activities of daily life).
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: T. Rackoll, C. Werner, A. Fl öel Source Type: research

FV 1. Perilesional activation in poststroke language recovery
Poststroke aphasia recovery evolves in time. Increased perilesional activity associated with treatment-related language improvements has been confirmed in the chronic phase (Fridriksson et al., 2011), but has not yet been systematically demonstrated during the early phases of stroke recovery. The pathophysiology of stroke suggests that perilesional reorganisation evolves within days, lasting for months after stroke, while increased neuronal excitability might provide a basis for perilesional neuroplasticity (Schiene et al., 1999).
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: A. Stockert, J. Klingbeil, M. Wawrzyniak, K. Wrede, D. Saur Tags: Orals – Functional Imaging Source Type: research

ID 448 – Brain-guided therapy in post-stroke aphasia
Find a novel approach for therapy of post-stroke aphasia utilizing personal-emotional words identified in a pre-therapy brain function assessment.
Source: Clinical Neurophysiology - February 11, 2016 Category: Neuroscience Authors: E. Willmott, S.C. Purdy Source Type: research

Adult onset ictal aphasia with epileptic discharges in Broca’s and Wernicke’s areas
Aphasia can sometimes present with epileptic seizures, especially in temporal lobe epilepsy affecting the dominant hemisphere. Child-onset epilepsy with aphasia is known as Landau-Kleffner Syndrome (Caraballo et al., 2014), whereas adult-onset epilepsy presenting with aphasia is quite rare, as aphasia more often presents with stroke in adult patients. Here we describe a patient with adult-onset epilepsy exhibiting ictal aphasia, and whose epileptic discharges were detected by magnetoencephalography (MEG) in the motor and sensory speech areas.
Source: Clinical Neurophysiology - November 19, 2015 Category: Neuroscience Authors: Shin-ichi Tokushige, Yasuo Terao, Naohiro Uchio, Shoji Tsuji, Masato Yumoto Tags: Letter to the Editor Source Type: research

112. Low frequency repetitive transcranial magnetic stimulation in early phase of rehabilitation of patients with post-stroke aphasia
About 50% of post-stroke patients remain aphasic a condition that greatly impede their reintegration to society. Results of Repetitive Transcranial Magnetic Stimulation (rTMS) as supplementary treatment for sub-acute post-stroke aphasia are controversial. We assessed the efficacy of inhibitory rTMS with conventional speech therapy to help recovery language performance in sub-acute stroke aphasia.In a randomised case-control double-blind study 12 non-fluent aphasic were consecutively enrolled. All patients suffered a first-ever stroke in the sub-acute stage defined as time since lesion onset from 1 month post-stroke.
Source: Clinical Neurophysiology - December 13, 2014 Category: Neuroscience Authors: R. Carrai, A. Grippo, A. Angelini, A. Vettori, T. Atzori, C. Falsini, M. Martini, A. Pizzi Source Type: research

146. Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca’s region improves naming in chronic post-stroke aphasia
This study aimed to compare the effect of excitatory, inhibitory and sham rTMS delivered with H-coil over the right inferior frontal gyrus (IFG) in chronic aphasic patients. Five right-handed post-stroke aphasic patients underwent a picture naming task before and immediately after each of three sessions of rTMS: excitatory (10Hz), inhibitory (1Hz) and sham rTMS, in random sequence and separated by at least 1 week. Only the excitatory 10Hz stimulation was associated with a significant improvement in naming performance, (p=0.043) and was significantly more effective than 1Hz rTMS (p=0.043). A single session of excitatory dee...
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: R. Chieffo, F. Ferrari, P. Battista, E. Houdayer, A. Nuara, F. Alemanno, J. Abutalebi, A. Zangen, G. Comi, S.F. Cappa, L. Leocani Tags: Society Proceedings Source Type: research

P 240. Improvement of language functions in a chronic non-fluent post-stroke aphasic patient following sequential bilateral non-invasive neuromodulation by theta burst magnetic stimulation
Conclusions: Described sequential bilateral physiologically balanced TMS modulation of activation of the language related areas of both hemispheres may result in considerable and rather fast language benefits in chronic nfA patients. Whether this approach is better than usual unilateral stimulation requires further studies.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: S. Filipovic, V. Stevanovic, I. Avramovic, M. Jelic, I. Avramovic, A. Jeremic, K. Kacar, S. Milanovic, L. Konstantinovic, J. Vuksanovic Tags: Society Proceedings Source Type: research

P 126. Righthemispheric inhibitory rTMS in patients with letfsided brain infarcts: Effect on cerebral blood flow using PET and speech performance
Discussion: rTMS with inhibitory effect on the rightsided homologous speech area plus speech therapy in patients with left sided brain infarcts and aphasia results in better recovery of language performance compared to patients who received speech therapy only.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: A. Hartmann, I. Rubi-Fessen, W.-D. Heiß, L. Kracht, J. Kessler, T. Rommel Tags: Society Proceedings Source Type: research

P 102. Transcranial direct current stimulation for improving aphasia after stroke. First results of a systematic Cochrane Review
Conclusion: Our review showed that in some studies tDCS might facilitate word retrieval after stroke and hence might improve aphasia. However, it is still unclear if tDCS could improve functional communication. Thus further research seems to be needed.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: B. Elsner, J. Kugler, M. Pohl, J. Mehrholz Tags: Society Proceedings Source Type: research

P 114. Anodal transcranial direct current stimulation in early treatment of post-stroke non-fluent aphasia
Conclusions: The findings provide only a weak evidence of A-tDCS behavioural gains during early neurorehabilitation of post-stroke aphasia. Further research is needed to investigate the effectiveness of this kind of neuromodulation. Different modes and parameters of tDCS should be explored considering such important factors determining recovery from aphasia as type and severity of language impairment, lesion site and size, time since stroke, and degree of hemispheric language laterality.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: K. Polanowska, M. Leśniak, J. Seniów Tags: Society Proceedings Source Type: research

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