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87. Anodal transcranial direct current stimulation of motor cortex does not ameliorates spasticity in multiple sclerosis
Spasticity is a common disorder and a major cause of a long-term disability in patients with multiple sclerosis (MS). Transcranial direct current stimulation (tDCs) is a potential tool to improve motor deficits in several neurological disease and, recently, it has been proposed as effective in decreasing spasticity after stroke. To assess whether anodal tDCS is effective in modulating lower limb spasticity in MS patients. We performed a single-centre randomized, double-blind, sham-controlled study to investigate efficacy of anodal vs sham tDCs in 20 relapsing-remitting MS patients.
Source: Clinical Neurophysiology - December 13, 2014 Category: Neuroscience Authors: R. Iodice, F. Manganelli, L. Ruggiero, R. Dubbioso, L. Santoro Source Type: research

The P300 in middle cerebral artery strokes or hemorrhages: Outcome predictions and source localization
Stroke is the leading cause of disability and is the third leading cause of death worldwide (Murray and Lopez, 1997). According to the World Health Organisation, a total of 15 million people suffer a stroke each year. Strokes can principally be classified into two main categories, ischemic and hemorrhagic (Donnan et al., 2008). 85% of all strokes are of ischemic origin (Qureshi et al., 2001) and most commonly occur within the territory of the middle cerebral artery (MCA). The MCA supplies the lateral portion of the cerebral cortex (about 60–70% of the hemisphere).
Source: Clinical Neurophysiology - November 1, 2014 Category: Neuroscience Authors: Mana R. Ehlers, Carmen López Herrero, Andreas Kastrup, Helmut Hildebrandt Source Type: research

The P300 in middle cerebral artery strokes or hemorrhages: outcome predictions and source localisation
Stroke is the leading cause of disability and is the third leading cause of death worldwide (Murray and Lopez, 1997). According to the World Health Organisation, a total of 15 million people suffer a stroke each year. Strokes can principally be classified into two main categories, ischemic and hemorrhagic (Donnan et al., 2008). 85 % of all strokes are of ischemic origin (Qureshi et al., 2001) and most commonly occur within the territory of the middle cerebral artery (MCA). The MCA supplies the lateral portion of the cerebral cortex (about 60 % - 70 % of the hemisphere).
Source: Clinical Neurophysiology - November 1, 2014 Category: Neuroscience Authors: Mana R. Ehlers, Carmen López Herrero, Andreas Kastrup, Helmut Hildebrandt Source Type: research

Timing of motor cortical stimulation during planar robotic training differentially impacts neuroplasticity in older adults
Neurorehabilitation efforts have focused on intense structured interventions to promote neuroplasticity because stroke is a leading cause of long-term disability world-wide. Robotic rehabilitation devices assist massed practice of upper extremity movement at high repetition rates (Lo et al., 2010; Conroy et al., 2011). They can also be used to change the learning environment, e.g., provide assistance or resistance to the motor task or train new mappings for movement to environmental effect (Krebs et al., 1998; Stein et al., 2004; MacClellan et al., 2005).
Source: Clinical Neurophysiology - September 15, 2014 Category: Neuroscience Authors: Crystal L. Massie, Shailesh S. Kantak, Priya Narayanan, George F. Wittenberg Source Type: research

A region-based two-step P300-based brain–computer interface for patients with amyotrophic lateral sclerosis
The brain–computer interface (BCI) or brain–machine interface (BMI) is an interface technology that enables communication with others and control of the environment or of a prosthesis without any muscle movement (Wolpaw et al., 2002; Birbaumer and Cohen, 2007; Daly and Wolpaw, 2008). In this decade, the use of BCI technology has become widespread, mainly for preclinical research, due to technical and mechanical improvements, and new technology been designed to help individuals with severe neurological disabilities, especially motor difficulties such as amyotrophic lateral sclerosis (ALS), spinal cord injury (SCI), and cerebral stroke.
Source: Clinical Neurophysiology - March 26, 2014 Category: Neuroscience Authors: Shiro Ikegami, Kouji Takano, Kiyohiko Kondo, Naokatsu Saeki, Kenji Kansaku Source Type: research

59. Alterations of the electroencephalographic rhythms in children with Sickle Cell disease (SCD): Source analysis with LORETA
Sickle Cell Disease (SCD) is a congenital familial pathology of the haemoglobin and it is classified as the most common genetic disease in the world.Neurological complications are very frequent: symptomatic stroke occurs in 11% of the SCD patients before they reach 20years of age, while 35% of the patients shows silent damages at the RMN with cognitive impairments and learning disabilities. The aim of this study is to verify the hypothesis that a different cerebral maturation between children with SCD and healthy controls exists. This has been achieved with the spectral analysis of electroencephalographic (EEG) rhythms and...
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: A. Bertoldo, P. Rampazzo, R. Manara, R. Colombatti, L. Sainati, M. Ermani Tags: Society Proceedings Source Type: research

P 181. Impact of offline transcranial direct current stimulation on consolidation of motor sequence learning in healthy elderly subjects
Conclusions: Offline application of anodal tDCS over M1 post training improves consolidation of motor sequence learning in elderly subjects until at least 22h post training. Further studies are needed to investigate the potential benefit of offline-tDCS in motor learning in healthy elderly and stroke patients.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: M. Wegscheider, J.-J. Rumpf, C. Fricke, D. Weise, J. Classen Tags: Society Proceedings Source Type: research

P 168. TMS neurophysiology and interventional rTMS in children with perinatal stroke: Safety and tolerability in the PLASTIC CHAMPS trial
Introduction/Question: Perinatal stroke causes hemiplegic cerebral palsy and lifelong disability. TMS can define neurophysiology and central therapeutic targets while rTMS carries therapeutic potential in adult stroke but have not been applied to the more plastic developing brain. Ipsilateral projections from the unlesioned hemisphere to the affected hand are prominent in this population and the effects of non-lesioned inhibitory rTMS are unknown.Methods: PLASTIC CHAMPS is a randomized, blinded, factorial clinical trial of rTMS and constraint therapy (CIMT) to enhance upper extremity function in children (6–18years) with...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: T. Rajapakse, O. Kirton, J. Roe, A. Kirton Tags: Society Proceedings Source Type: research

P 78. The prognostic value of motor-evoked potentials in motor recovery and functional outcome after stroke – a systematic review of the literature
Conclusions: TMS may be helpful in prognosis of motor recovery and functional outcome in stroke patients, and may become additional tool in making decision about qualification to rehabilitation ward and length of rehabilitation process. However, further studies are necessary to determine the real value of this method. The interpretation of the results of our review was complicated by methodological variation between the included studies.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: J. Bembenek, K. Kurczych, M. Karlinski, A. Czlonkowska Tags: Society Proceedings Source Type: research

IS 45. Brain stimulation-enhanced therapy for visual neglect
Conclusions: This is the first proof-of-principle demonstration that a single-shot, simple behavioural procedure combined with TDCS can remediate treatment-unresponsive chronic visual neglect. TDCS provoked a positive therapeutic response in patients who did not otherwise respond to the behavioural therapy. By enhancing the consolidation of prism therapy, TDCS increased both the gain and longevity of therapeutic response, yielding large, long-lasting improvements in visual neglect.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: J. O’Shea, P. Revol, H. Cousijn, J. Near, C. Stagg, G. Rode, Y. Rossetti Tags: Society Proceedings Source Type: research

P 181. Impact of offline transcranial direct current stimulation on consolidation of motor sequence learning in healthy elderly subjects
Conclusions: Offline application of anodal tDCS over M1 post training improves consolidation of motor sequence learning in elderly subjects until at least 22h post training. Further studies are needed to investigate the potential benefit of offline-tDCS in motor learning in healthy elderly and stroke patients.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: M. Wegscheider, J.-J. Rumpf, C. Fricke, D. Weise, J. Classen Tags: Society Proceedings Source Type: research

P 168. TMS neurophysiology and interventional rTMS in children with perinatal stroke: Safety and tolerability in the PLASTIC CHAMPS trial
Introduction/Question: Perinatal stroke causes hemiplegic cerebral palsy and lifelong disability. TMS can define neurophysiology and central therapeutic targets while rTMS carries therapeutic potential in adult stroke but have not been applied to the more plastic developing brain. Ipsilateral projections from the unlesioned hemisphere to the affected hand are prominent in this population and the effects of non-lesioned inhibitory rTMS are unknown.Methods: PLASTIC CHAMPS is a randomized, blinded, factorial clinical trial of rTMS and constraint therapy (CIMT) to enhance upper extremity function in children (6–18years) with...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: T. Rajapakse, O. Kirton, J. Roe, A. Kirton Tags: Society Proceedings Source Type: research

P 78. The prognostic value of motor-evoked potentials in motor recovery and functional outcome after stroke – a systematic review of the literature
Conclusions: TMS may be helpful in prognosis of motor recovery and functional outcome in stroke patients, and may become additional tool in making decision about qualification to rehabilitation ward and length of rehabilitation process. However, further studies are necessary to determine the real value of this method. The interpretation of the results of our review was complicated by methodological variation between the included studies.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: J. Bembenek, K. Kurczych, M. Karlinski, A. Czlonkowska Tags: Society Proceedings Source Type: research

IS 45. Brain stimulation-enhanced therapy for visual neglect
Conclusions: This is the first proof-of-principle demonstration that a single-shot, simple behavioural procedure combined with TDCS can remediate treatment-unresponsive chronic visual neglect. TDCS provoked a positive therapeutic response in patients who did not otherwise respond to the behavioural therapy. By enhancing the consolidation of prism therapy, TDCS increased both the gain and longevity of therapeutic response, yielding large, long-lasting improvements in visual neglect.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: J. O’Shea, P. Revol, H. Cousijn, J. Near, C. Stagg, G. Rode, Y. Rossetti Tags: Society Proceedings Source Type: research

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