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Transcranial magnetic stimulation to assess motor neurophysiology after acute stroke in the United States: Feasibility, lessons learned, and values for future research
Transcranial magnetic stimulation (TMS) has been widely applied in both basic and clinical neuroscience since its introduction in 1985. In addition to its potential therapeutic value for exciting or inhibiting neural circuits [1], TMS can be used to investigate corticomotor excitability (CME), which is a key aspect of voluntary movement [2]. For example, single-pulse TMS can elicit electrical signals, which propagate along descending motor pathways and are recorded as motor evoked potentials (MEP) in target muscles.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 6, 2021 Category: Neurology Authors: Yi-Ling Kuo, David J. Lin, Isha Vora, Julie A. DiCarlo, Dylan J. Edwards, Teresa J. Kimberley Source Type: research

Non-invasive neuromodulation trials in children: Lessons from perinatal stroke
Introduction: Therapeutic applications of non-invasive brain stimulation are rapidly expanding. Principles are increasingly established, including directional modulation of informed cortical targets, facilitating clinical trial design. The worry is that the high prevalence of burdensome diseases with limited treatment options coupled with unchecked enthusiasm may be allowing trial applications to get ahead of rationale evidence. Concern is even greater in the developing brain where experience is limited and additional issues merit consideration.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: A. Kirton Source Type: research