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The unusual case of dental pain with sham repetitive transcranial magnetic stimulation: a benign idiosyncrasy or diagnostic opportunity?
Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder [1]. Recently, we investigated 10 sessions of high-frequency rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in chronic stroke survivors with depression (randomised controlled trial; ACTRN12619001303134; institutional ethics approval 200697). Stimulation was delivered at 110% resting motor threshold at 10 Hz for a total of 3000 pulses. Here we report the experience of a 51-year-old male with mild upper-limb impairment (Fugl-Meyer 49/66; structural imaging Figure 1), who experienced anatomically confine...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 9, 2019 Category: Neurology Authors: Brenton Hordacre, Kristina Comacchio, G. Lorimer Moseley Source Type: research

Feasibility of home-based, self-applied transcranial direct current stimulation to enhance motor learning in middle-aged and older adults
We read with great interest the recent letter sent to you by McConnell and colleagues [1], in which they discuss one of the first applications of truly independent home-based electrical brain stimulation, applied following safety recommendations. Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique capable of modulating cortical excitability beyond the stimulation period [2,3]. tDCS presents interesting options as a therapeutic intervention in multiple neurological disorders, such as stroke, depression, chronic pain, schizophrenia, and Alzheimer ’s and Parkinson’s disease [4,5].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 23, 2019 Category: Neurology Authors: Pablo Maceira-Elvira, Traian Popa, Anne-Christine Schmid, Friedhelm C. Hummel Source Type: research

Proceedings #39: Effects of tDCS alone and combined with virtual reality in clinical practice
The brain can be modulated by electricity and emotions. We performed an open-label study in 134 patients with many clinical conditions, specially stroke, chronic pain and depression. The set up for transcranial direct current stimulation (tDCS) was dependent of the disease using always an intensity of 2 mA/30 min/day for 20 days. Virtual reality (VR) was applied concomitantly using an Oculus Rift. The outcomes were based on the subjective perception of the patients as follows: 1=no response at all, 2=mild response during the stimulation and 3=consistent response after 3 months of follow-up.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Milena Artifon, Lauren Adachi, Pedro Schestatsky Source Type: research

Seizure induced by repetitive transcranial magnetic stimulation for central pain: adapted guidelines for post-stroke patients
We report the following TMS-related seizure:
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 23, 2017 Category: Neurology Authors: M élanie Cogné, Cédric Gil-Jardiné, Pierre-Alain Joseph, Dominique Guehl, Bertrand Glize Source Type: research

Magnetic focusing by magnetic shielding for Non-Invasive Brain Stimulation
Instruction: Transcranial magnetic stimulation (TMS) is one of the most widely used methods for brain stimulation. It is utilized in diagnosis and treatment for many neural diseases, such as neuropathic pain and loss of function caused by stroke. Current commercial TMS stimulators cannot provide well targeted stimulation. Due to fast field divergence, the effective distance in TMS is limited to around 1.5 cm. A breakthrough is needed to achieve non-invasive, focused brain stimulation.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: Q. Meng, M. Cherry, X. Du, H. Lu, E. Hong, Y. Yang, F.-S. Choa Source Type: research

Chronic post stroke central pain: Increased success rate of chronic epidural motor cortex stimulation using somatotopic, navigated repetitive TMS for patient selection and implant placement
Neuromodulation for severe central pain using repetitive stimulation of motor cortices has been used for more than two decades, first via direct cortical stimulation (DCS) by implanted electrodes, later non-invasively mainly by repetitive transcranial magnetic stimulation (rTMS). The outcome at group level has been limited, though for some, the effects have been of large value. There is a need for selection of patients that are likely to benefit from this procedure. Based on a preliminary report indicating that rTMS could contribute to this, we aimed to address this problem.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Thordstein, G. Pegenius, K. Gatzinsky Source Type: research

The outlook for non-invasive electrical brain stimulation
Over a decade since the initial establishment of modern transcranial direct current stimulation (tDCS), the field of transcranial electrical stimulation (tES) has blossomed to include a range of techniques (e.g., alternating current (tACS), random noise (tRNS), and pulsed current stimulation), and a diverse array of applications (e.g., depression, pain, tinnitus, stroke, and schizophrenia). At the cusp of even broader dissemination of tES as a tool for the treatment and rehabilitation of brain disorders, the study of brain function, and brain enhancement, it is incumbent to consolidate what have we learned and what remains to be addressed.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 23, 2014 Category: Neurology Authors: Marom Bikson, Dylan Edwards, Emily Kappenman Source Type: research