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The unusual case of dental pain with sham repetitive transcranial magnetic stimulation: a benign idiosyncrasy or diagnostic opportunity?
Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder [1]. Recently, we investigated 10 sessions of high-frequency rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in chronic stroke survivors with depression (randomised controlled trial; ACTRN12619001303134; institutional ethics approval 200697). Stimulation was delivered at 110% resting motor threshold at 10 Hz for a total of 3000 pulses. Here we report the experience of a 51-year-old male with mild upper-limb impairment (Fugl-Meyer 49/66; structural imaging Figure 1), who experienced anatomically confine...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 9, 2019 Category: Neurology Authors: Brenton Hordacre, Kristina Comacchio, G. Lorimer Moseley Source Type: research

Feasibility of home-based, self-applied transcranial direct current stimulation to enhance motor learning in middle-aged and older adults
We read with great interest the recent letter sent to you by McConnell and colleagues [1], in which they discuss one of the first applications of truly independent home-based electrical brain stimulation, applied following safety recommendations. Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique capable of modulating cortical excitability beyond the stimulation period [2,3]. tDCS presents interesting options as a therapeutic intervention in multiple neurological disorders, such as stroke, depression, chronic pain, schizophrenia, and Alzheimer ’s and Parkinson’s disease [4,5].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 23, 2019 Category: Neurology Authors: Pablo Maceira-Elvira, Traian Popa, Anne-Christine Schmid, Friedhelm C. Hummel Source Type: research

Proceedings #39: Effects of tDCS alone and combined with virtual reality in clinical practice
The brain can be modulated by electricity and emotions. We performed an open-label study in 134 patients with many clinical conditions, specially stroke, chronic pain and depression. The set up for transcranial direct current stimulation (tDCS) was dependent of the disease using always an intensity of 2 mA/30 min/day for 20 days. Virtual reality (VR) was applied concomitantly using an Oculus Rift. The outcomes were based on the subjective perception of the patients as follows: 1=no response at all, 2=mild response during the stimulation and 3=consistent response after 3 months of follow-up.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Milena Artifon, Lauren Adachi, Pedro Schestatsky Source Type: research

Chronic post stroke central pain: Increased success rate of chronic epidural motor cortex stimulation using somatotopic, navigated repetitive TMS for patient selection and implant placement
Neuromodulation for severe central pain using repetitive stimulation of motor cortices has been used for more than two decades, first via direct cortical stimulation (DCS) by implanted electrodes, later non-invasively mainly by repetitive transcranial magnetic stimulation (rTMS). The outcome at group level has been limited, though for some, the effects have been of large value. There is a need for selection of patients that are likely to benefit from this procedure. Based on a preliminary report indicating that rTMS could contribute to this, we aimed to address this problem.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Thordstein, G. Pegenius, K. Gatzinsky Source Type: research