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Transcutaneous auricular vagus nerve stimulation (taVNS) decreases heart rate acutely in neonatal rats
Transcutaneous auricular vagus nerve stimulation (taVNS) is an exciting non-invasive extension of traditional invasive cervical VNS. However, it is still unclear what vagus fibers taVNS engages and whether taVNS has measurable effects in reducing heart rate (HR) to assess parasympathetic nervous system activation. Ongoing research and clinical applications pairing VNS with activities promoting learning and stroke recovery are promising [1]. taVNS has also been used in newborns with hypoxic-ischemic (HI) brain injury and may improve their oromotor coordination during feeding [2].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - August 21, 2023 Category: Neurology Authors: Melanie W. Gail, Catrina Sims-Robinson, Heather Boger, Adviye Ergul, Rupak Mukherjee, Dorothea D. Jenkins, Mark S. George Source Type: research

Investigate the neuroprotective effects of electrical stimulation following acute ischemic stroke in non-human primates
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 1, 2023 Category: Neurology Authors: Jasmine Zhou, Karam Khateeb, Aryaman Gala, Mona Rahimi, Azadeh Yazdan-Shahmorad Source Type: research

Brain derived neurotrophic factor negatively responded to transcranial direct current stimulation in ischemic stroke patients: randomized controlled trial
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 1, 2023 Category: Neurology Authors: Hussein Youssef, Nema Abdelhamed, Mohamed Hamdy Source Type: research

Remote ischemic precondition for secondary stroke prevention
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 1, 2023 Category: Neurology Authors: Xunming Ji Source Type: research

Sphenopalatine ganglion stimulation to treat acute ischemic stroke
Symposium title: Neuromodulation for acute stroke treatment, prevention and recovery
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 1, 2023 Category: Neurology Authors: Natan Borstein Source Type: research

Single session of high amperage transcranial direct current stimulation shows differential montage effect on cortical excitability in ischemic stroke patients
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Pratik Chhatbar, Emily Grattan, Scott Hutchison, Viswanathan Ramakrishnan, William DeVries, Mark George, Steven Kautz, Wayne Feng Source Type: research

Novel and non-invasive brain-computer interface-based stimulation device using frequency tuned electromagnetic fields to significantly reduce disability following sub-acute ischemic stroke: A pilot randomized controlled trial
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Batsheva Weisinger, Natan M. Bornstein, Esther Shohami, Yaron Segal, Ariela Alter, Assaf Lifshitz, Atul Prasad, Dharam P. Pandey Source Type: research

Proceedings #18: Paradoxal Heightened Ipsilesional Corticospinal Excitability in Mild to Moderate Hemiplegia
Stroke is responsible for one out of every twenty deaths in the world and is a leading cause of serious long-term disabilities. Transcranial magnetic stimulation (TMS) is used clinically to measure and evaluate the integrity of the corticospinal pathway via the electromyographic response termed, the Motor Evoked Potential (MEP). The aim is to investigate corticospinal excitability from the affected and unaffected motor cortex in chronic post-stroke hemiparesis. The data used in this project form the baseline collection of a broader interventional study, in first time ischemic stroke patients with residual right hemiparesis...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Celeste R.S. De Camargo, Mar Cortes, Avrielle Rykman Peltz, Dylan Edwards Source Type: research

Abstract #24: Transcranial direct current stimulation (tDCS) electric field modeling in children after perinatal stroke
Background: Perinatal stroke (PS), the leading cause of hemiparetic cerebral palsy (HCP), typically results from occlusion of the middle cerebral artery (arterial ischemic stroke, AIS). Subsequent motor impairments last a lifetime and improving function is difficult. Transcranial direct-current stimulation (tDCS) is a form of non-invasive brain stimulation that may facilitate neuroplasticity and improve function. How current moves through the developing brain is different from adults. Modeling tDCS-induced electric fields (EF) is feasible but individual idiosyncrasies in lesion topology, white (WM) and grey matter (GM) arc...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: H.L. Carlson, A. Giuffre, P. Ciechanski, A. Kirton Source Type: research

Abstract #4: Pipeline Verification for the Identification of Noninvasive Neuromodulation Targets for Pediatric Stroke Rehabilitation
Introduction: Ischemic perinatal stroke affects as many as 1 in 2,300 live births and may result in lifelong burden of care. Thus, better rehabilitation techniques are indicated to improve quality of life for individuals and families. Implementing interventions early in life can harness neuroplastic potential to promote recovery. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have shown promise as noninvasive cortical assessment and neuromodulation techniques for stroke rehabilitation; regaining motor control and function can be facilitated through the induction of plasticity.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Kathleen E. Mantell, Samuel T. Nemanich, Ellen Sutter, Bernadette T. Gillick, Alexander Opitz Source Type: research

Intermittent theta burst stimulation plus external counterpulsation for upper limb motor recovery after ischemic stroke
Background and Purpose: Upper limb dysfunction is common after ischemic stroke. The single application of intermittent theta burst stimulation (iTBS) or external counterpulsation (ECP) has been proved effectively to enhance the cortical motor excitability in previous researches. However, it still needs to verify the augment effect and its duration when these two treatments are applied orderly. We hypothesized that there was a synergistic effect of ECP followed by iTBS to upper limb function through the improvement in both the cerebral perfusion and neuron excitability.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: W. He, T. Leung, H. Leung, L. Wong Source Type: research

Extremely low frequency magnetic fields as neuroprotective treatment in acute ischemic stroke
Introduction and aims: Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. In this open-label, one arm, dose-escalation, exploratory study we evaluated the safety and tolerability of ELF-MF in acute ischemic stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: F. Capone, M. Liberti, F. Apollonio, F. Camera, C. Quattrocchi, M. Francesco, V. Di Lazzaro Source Type: research

Insights from rodent stroke models
Ischemic injuries within the motor cortex results in functional deficits that profoundly impact activities of daily living in patients. Current rehabilitation protocols achieve only limited recovery of motor abilities. The brain reorganizes spontaneously after injury, and it is believed that appropriately boosting these neuroplastic processes may restore function via recruitment of spared areas and pathways. In this presentation, I will describe our recent work on novel experimental therapies for the recovery of motor function in a mouse model of focal stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: M. Caleo, C. Spalletti, C. Alia Source Type: research

Motor control in stroke
: Most recovery from motor impairment after stroke occurs early, and is largely complete by 3-6 months. Data from human studies suggests that this recovery of motor impairment occurs independently of rehabilitation interventions, which often target functional activities that rely on compensatory strategies. Motor impairment can further be dissected into strength and motor control using kinematic tasks that minimize contributions of strength. In a longitudinal study, upper limb motor impairment was tracked over the first year after ischemic stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: T. Kitago Source Type: research

Cerebellar low-intensity focused ultrasound stimulation can normalize asymmetrical hemispheric delta power after mouse ischemic stroke
Introduction: Functional asymmetry between lesioned and non-lesioned hemispheres after unilateral middle cerebral artery (MCA) stroke could be indicative of cerebral pathophysiology. We propose a low-intensity focused ultrasound (LIFU) can non-invasively stimulate the deep cerebellar nuclei and induce plasticity for reestablishing the balance between two cerebral hemispheres.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: H. Baek, A. Sariev, S. Dong, S. Royer, H. Kim Source Type: research

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