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Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women
CONCLUSIONS: When compared to regular salt, LSSS probably reduce blood pressure, non-fatal cardiovascular events and cardiovascular mortality slightly in adults. However, LSSS also probably increase blood potassium slightly in adults. These small effects may be important when LSSS interventions are implemented at the population level. Evidence is limited for adults without elevated blood pressure, and there is a lack of evidence in pregnant women and people in whom an increased potassium intake is known to be potentially harmful, limiting conclusions on the safety of LSSS in the general population. We also cannot draw firm...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Amanda Brand Marianne E Visser Anel Schoonees Celeste E Naude Source Type: research

Screening strategies for hypertension.
CONCLUSIONS: There is an implicit assumption that early detection of hypertension through screening can reduce the burden of morbidity and mortality, but this assumption has not been tested in rigorous research studies. High-quality evidence from RCTs or programmatic evidence from NRCTs on the effectiveness and costs or harms of different screening strategies for hypertension (mass, targeted, or opportunistic) to reduce hypertension-related morbidity and mortality is lacking. PMID: 32378196 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - May 6, 2020 Category: General Medicine Authors: Schmidt BM, Durao S, Toews I, Bavuma CM, Hohlfeld A, Nury E, Meerpohl JJ, Kredo T Tags: Cochrane Database Syst Rev Source Type: research

Interventions for treating urinary incontinence after stroke in adults.
CONCLUSIONS: There is insufficient evidence to guide continence care of adults in the rehabilitative phase after stroke. As few trials tested the same intervention, conclusions are drawn from few, usually small, trials. CIs were wide, making it difficult to ascertain if there were clinically important differences. Only four trials had adequate allocation concealment and many were limited by poor reporting, making it impossible to judge the extent to which they were prone to bias. More appropriately powered, multicentre trials of interventions are required to provide robust evidence for interventions to improve urinary inco...
Source: Cochrane Database of Systematic Reviews - February 1, 2019 Category: General Medicine Authors: Thomas LH, Coupe J, Cross LD, Tan AL, Watkins CL Tags: Cochrane Database Syst Rev Source Type: research