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Source: Cochrane Database of Systematic Reviews
Condition: Stroke

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Total 462 results found since Jan 2013.

Pharmacotherapy for hypertension in adults aged 18 to 59 years.
CONCLUSIONS: Antihypertensive drugs used to treat predominantly healthy adults aged 18 to 59 years with mild to moderate primary hypertension have a small absolute effect to reduce cardiovascular mortality and morbidity primarily due to reduction in cerebrovascular mortality and morbidity. All-cause mortality and coronary heart disease were not reduced. There is lack of good evidence on withdrawal due to adverse events. Future trials in this age group should be at least 10 years in duration and should compare different first-line drug classes and strategies. PMID: 28813123 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 16, 2017 Category: General Medicine Authors: Musini VM, Gueyffier F, Puil L, Salzwedel DM, Wright JM Tags: Cochrane Database Syst Rev Source Type: research

Blood pressure targets for hypertension in older adults.
CONCLUSIONS: At the present time there is insufficient evidence to know whether a higher BP target (less than150 to 160/95 to 105 mmHg) or a lower BP target (less than 140/90 mmHg) is better for older adults with high BP. Additional good-quality trials assessing BP targets in this population are needed. PMID: 28787537 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 8, 2017 Category: General Medicine Authors: Garrison SR, Kolber MR, Korownyk CS, McCracken RK, Heran BS, Allan GM Tags: Cochrane Database Syst Rev Source Type: research

Low glycaemic index diets for the prevention of cardiovascular disease.
CONCLUSIONS: There is currently no evidence available regarding the effect of low GI diets on cardiovascular disease events. Moreover, there is currently no convincing evidence that low GI diets have a clear beneficial effect on blood lipids or blood pressure parameters. PMID: 28759107 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 31, 2017 Category: General Medicine Authors: Clar C, Al-Khudairy L, Loveman E, Kelly SA, Hartley L, Flowers N, Germanò R, Frost G, Rees K Tags: Cochrane Database Syst Rev Source Type: research

Occupational therapy for adults with problems in activities of daily living after stroke.
CONCLUSIONS: We found low-quality evidence that occupational therapy targeted towards activities of daily living after stroke can improve performance in activities of daily living and reduce the risk of deterioration in these abilities. Because the included studies had methodological flaws, this research does not provide a reliable indication of the likely effect of occupational therapy for adults with stroke. PMID: 28721691 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 19, 2017 Category: General Medicine Authors: Legg LA, Lewis SR, Schofield-Robinson OJ, Drummond A, Langhorne P Tags: Cochrane Database Syst Rev Source Type: research

Early supported discharge services for people with acute stroke.
CONCLUSIONS: Appropriately resourced ESD services with co-ordinated multidisciplinary team input provided for a selected group of stroke patients can reduce long-term dependency and admission to institutional care as well as reducing the length of hospital stay. Results are inconclusive for services without co-ordinated multidisciplinary team input. We observed no adverse impact on the mood or subjective health status of patients or carers, nor on readmission to hospital. PMID: 28703869 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 13, 2017 Category: General Medicine Authors: Langhorne P, Baylan S, Early Supported Discharge Trialists Tags: Cochrane Database Syst Rev Source Type: research

Early discharge hospital at home.
CONCLUSIONS: Despite increasing interest in the potential of early discharge hospital at home services as a less expensive alternative to inpatient care, this review provides insufficient evidence of economic benefit (through a reduction in hospital length of stay) or improved health outcomes. PMID: 28651296 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 26, 2017 Category: General Medicine Authors: Gonçalves-Bradley DC, Iliffe S, Doll HA, Broad J, Gladman J, Langhorne P, Richards SH, Shepperd S Tags: Cochrane Database Syst Rev Source Type: research

Repetitive peripheral magnetic stimulation for activities of daily living and functional ability in people after stroke.
CONCLUSIONS: Available trials provided inadequate evidence to permit any conclusions about routine use of rPMS for people after stroke. Additional trials with large sample sizes are needed to determine an appropriate rPMS protocol as well as long-term effects. We identified three ongoing trials and will include these trials in the next review update. PMID: 28644548 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 23, 2017 Category: General Medicine Authors: Momosaki R, Yamada N, Ota E, Abo M Tags: Cochrane Database Syst Rev Source Type: research

Interprofessional collaboration to improve professional practice and healthcare outcomes.
CONCLUSIONS: Given that the certainty of evidence from the included studies was judged to be low to very low, there is not sufficient evidence to draw clear conclusions on the effects of IPC interventions. Neverthess, due to the difficulties health professionals encounter when collaborating in clinical practice, it is encouraging that research on the number of interventions to improve IPC has increased since this review was last updated. While this field is developing, further rigorous, mixed-method studies are required. Future studies should focus on longer acclimatisation periods before evaluating newly implemented IPC i...
Source: Cochrane Database of Systematic Reviews - June 22, 2017 Category: General Medicine Authors: Reeves S, Pelone F, Harrison R, Goldman J, Zwarenstein M Tags: Cochrane Database Syst Rev Source Type: research

Treating periodontal disease for preventing adverse birth outcomes in pregnant women.
CONCLUSIONS: It is not clear if periodontal treatment during pregnancy has an impact on preterm birth (low-quality evidence). There is low-quality evidence that periodontal treatment may reduce low birth weight (< 2500 g), however, our confidence in the effect estimate is limited. There is insufficient evidence to determine which periodontal treatment is better in preventing adverse obstetric outcomes. Future research should aim to report periodontal outcomes alongside obstetric outcomes. PMID: 28605006 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 12, 2017 Category: General Medicine Authors: Iheozor-Ejiofor Z, Middleton P, Esposito M, Glenny AM Tags: Cochrane Database Syst Rev Source Type: research

Celecoxib for rheumatoid arthritis.
CONCLUSIONS: Celecoxib may improve clinical symptoms, alleviate pain and contribute to little or no difference in physical function compared with placebo. Celecoxib was associated with fewer numbers of participant withdrawals. Results for incidence of gastroduodenal ulcers (≥ 3 mm) and short-term serious adverse events were uncertain; however, there were few reported events for either.Celecoxib may slightly improve clinical symptoms compared with tNSAIDs. Results for reduced pain and improved physical function were uncertain. Particpants taking celecoxib had lower incidence of gastroduodenal ulcers (≥ 3 mm) and there w...
Source: Cochrane Database of Systematic Reviews - June 9, 2017 Category: General Medicine Authors: Fidahic M, Jelicic Kadic A, Radic M, Puljak L Tags: Cochrane Database Syst Rev Source Type: research

Carotid endarterectomy for symptomatic carotid stenosis.
CONCLUSIONS: Endarterectomy was of some benefit for participants with 50% to 69% symptomatic stenosis (moderate-quality evidence), and highly beneficial for those with 70% to 99% stenosis without near-occlusion (moderate-quality evidence). We found no benefit in people with carotid near-occlusion (high-quality evidence). PMID: 28590505 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 7, 2017 Category: General Medicine Authors: Orrapin S, Rerkasem K Tags: Cochrane Database Syst Rev Source Type: research

Circuit class therapy for improving mobility after stroke.
CONCLUSIONS: There is moderate evidence that CCT is effective in improving mobility for people after stroke - they may be able to walk further, faster, with more independence and confidence in their balance. The effects may be greater later after the stroke, and are of clinical significance. Further high-quality research is required, investigating quality of life, participation and cost-benefits, that compares CCT with standard care and that also investigates the influence of factors such as stroke severity and age. The potential risk of increased falls during CCT needs to be monitored. PMID: 28573757 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 2, 2017 Category: General Medicine Authors: English C, Hillier SL, Lynch EA Tags: Cochrane Database Syst Rev Source Type: research

Endovascular treatment for ruptured abdominal aortic aneurysm.
CONCLUSIONS: The conclusions of this review are currently limited by the paucity of data. We found from the data available moderate-quality evidence suggesting there is no difference in 30-day mortality between eEVAR and open repair. Not enough information was provided for complications for us to make a well-informed conclusion, although it is possible that eEVAR is associated with a reduction in bowel ischaemia. Long-term data were lacking for both survival and late complications. More high-quality randomised controlled trials comparing eEVAR and open repair for the treatment of RAAA are needed to better understand if one...
Source: Cochrane Database of Systematic Reviews - May 26, 2017 Category: General Medicine Authors: Badger S, Forster R, Blair PH, Ellis P, Kee F, Harkin DW Tags: Cochrane Database Syst Rev Source Type: research

Antithrombotic treatment after stroke due to intracerebral haemorrhage.
CONCLUSIONS: There is insufficient evidence from RCTs to support or discourage the use of antithrombotic treatment after ICH. RCTs comparing starting versus avoiding antiplatelet or anticoagulant drugs after ICH appear justified and are needed in clinical practice. PMID: 28540976 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 25, 2017 Category: General Medicine Authors: Perry LA, Berge E, Bowditch J, Forfang E, Rønning OM, Hankey GJ, Villanueva E, Al-Shahi Salman R Tags: Cochrane Database Syst Rev Source Type: research

Interventions for treating anxiety after stroke.
CONCLUSIONS: Evidence is insufficient to guide the treatment of anxiety after stroke. Further well-conducted randomised controlled trials (using placebo or attention controls) are required to assess pharmacological agents and psychological therapies. PMID: 28535332 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 23, 2017 Category: General Medicine Authors: Knapp P, Campbell Burton CA, Holmes J, Murray J, Gillespie D, Lightbody CE, Watkins CL, Chun HY, Lewis SR Tags: Cochrane Database Syst Rev Source Type: research