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Stretch reflex excitability in contralateral limbs of stroke survivors is higher than in matched controls
Spasticity, characterized by hyperreflexia, is a motor impairment that can arise following a hemispheric stroke. While the neural mechanisms underlying spasticity in chronic stroke survivors are unknown, one p...
Source: Journal of NeuroEngineering and Rehabilitation - December 5, 2019 Category: Rehabilitation Authors: Taimoor Afzal, Matthieu K. Chardon, William Z. Rymer and Nina L. Suresh Tags: Research Source Type: research

Spinal plasticity in robot-mediated therapy for the lower limbs
Robot-mediated therapy can help improve walking ability in patients following injuries to the central nervous system. However, the efficacy of this treatment varies between patients, and evidence for the mechanisms underlying functional improvements in humans is poor, particularly in terms of neural changes in the spinal cord. Here, we review the recent literature on spinal plasticity induced by robotic-based training in humans and propose recommendations for the measurement of spinal plasticity using robotic devices. Evidence for spinal plasticity in humans following robotic training is limited to the lower limbs. Body we...
Source: Journal of NeuroEngineering and Rehabilitation - September 17, 2015 Category: Rehabilitation Authors: Andrew StevensonNatalie Mrachacz-KerstingEdwin van AsseldonkDuncan TurnerErika Spaich Source Type: research

Comprehensive neuromechanical assessment in stroke patients: reliability and responsiveness of a protocol to measure neural and non-neural wrist properties
Conclusions: Passive, active and reflexive parameters can be assessed with high reliability in post-stroke patients. Parameters were responsive to clinical status. The next step is longitudinal measurement of passive, active and reflexive parameters to establish their predictive value for functional outcome after stroke.
Source: Journal of NeuroEngineering and Rehabilitation - March 13, 2015 Category: Rehabilitation Authors: Hanneke van der KrogtAsbjorn KlompJurriaan de GrootErwin de VlugtFrans van der HelmCarel MeskersJ Arendzen Source Type: research

Altering length and velocity feedback during a neuro-musculoskeletal simulation of normal gait contributes to hemiparetic gait characteristics
Conclusions: Our results support the idea that hyperexcitability of length and velocity feedback pathways, especially in combination with altered reflex modulation patterns, can contribute to deviations in hemiparetic gait. Surprisingly, our results showed only subtle temporal differences between length and velocity feedback. Therefore, we cannot attribute the effects seen in kinematics to one specific type of feedback.
Source: Journal of NeuroEngineering and Rehabilitation - April 30, 2014 Category: Rehabilitation Authors: Karen JansenFriedl De GrooteWouter AertsJoris De SchutterJacques DuysensIlse Jonkers Source Type: research

Chronic muscle stimulation improves muscle function and reverts the abnormal surface EMG pattern in Myotonic Dystrophy: a pilot study
Conclusions: NMES determined a clear-cut improvement of both the muscular weakness and the sarcolemmal excitability alteration in our small group of DM1 patients. Therefore this rehabilitative approach, if confirmed by further extensive studies, could be considered early in the management of muscular impairment in these patients. An attractive hypothesis to explain our encouraging result could be represented by a functional inhibition of SK3 channels expressed in muscle of DM1 subjects.
Source: Journal of NeuroEngineering and Rehabilitation - August 12, 2013 Category: Rehabilitation Authors: Carmelo ChisariFederica BertolucciStefania DaliseBruno Rossi Source Type: research

The physiological basis of neurorehabilitation - locomotor training after spinal cord injury
Advances in our understanding of the physiological basis of locomotion enable us to optimize the neurorehabilitation of patients with lesions to the central nervous system, such as stroke or spinal cord injury (SCI). It is generally accepted, based on work in animal models, that spinal neuronal machinery can produce a stepping-like output. In both incomplete and complete SCI subjects spinal locomotor circuitries can be activated by functional training which provides appropriate afferent feedback. In motor complete SCI subjects, however, motor functions caudal to the spinal cord lesion are no longer used resulting in neuron...
Source: Journal of NeuroEngineering and Rehabilitation - January 21, 2013 Category: Rehabilitation Authors: Michèle HubliVolker Dietz Source Type: research

Concurrent neuromechanical and functional gains following upper-extremity power training post-stroke
Background: Repetitive task practice is argued to drive neural plasticity following stroke. However, current evidence reveals that hemiparetic weakness impairs the capacity to perform, and practice, movements appropriately. Here we investigated how power training (i.e., high-intensity, dynamic resistance training) affects recovery of upper-extremity motor function post-stroke. We hypothesized that power training, as a component of upper-extremity rehabilitation, would promote greater functional gains than functional task practice without deleterious consequences.MethodNineteen chronic hemiparetic individuals were studied u...
Source: Journal of NeuroEngineering and Rehabilitation - January 21, 2013 Category: Rehabilitation Authors: Carolynn PattenElizabeth CondliffeChristine DairaghiPeter Lum Source Type: research