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Source: Clinical Cardiology
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Total 111 results found since Jan 2013.
Patients without comorbidities at the time of diagnosis of atrial fibrillation: causes of death during long ‐term follow‐up compared to matched controls
ConclusionsIn patients with incident AF and no known comorbidities at the time of AF diagnosis, only cardiovascular diseases were more often causes of death as compared to controls. Women carried a significantly higher relative risk than men.
Source: Clinical Cardiology - August 25, 2017 Category: Cardiology Authors: Tommy Andersson, Anders Magnuson, Ing ‐Liss Bryngelsson, Ole Frøbert, Karin M. Henriksson, Nils Edvardsson, Dritan Poçi Tags: CLINICAL INVESTIGATIONS Source Type: research
Atrial fibrillation variability on long ‐term monitoring of implantable cardiac rhythm management devices
ConclusionsSignificant temporal variability in AF burden exists when measured continuously with an implantable CRMD.
Source: Clinical Cardiology - August 1, 2017 Category: Cardiology Authors: Rachel M. Kaplan, Paul D. Ziegler, Jodi Koehler, Taya V. Glotzer, Rod S. Passman Tags: CLINICAL INVESTIGATIONS Source Type: research
Stroke or left atrial thrombus prediction using antithrombin III and mean platelet volume in patients with nonvalvular atrial fibrillation
ConclusionsHigh MPV and AT‐III deficiency were predictive markers for stroke or LA thrombus. Their predictive power for stroke was independent of antiplatelet treatment, anticoagulation therapy, and a high CHA2DS2‐VASc score in patients with AF.
Source: Clinical Cardiology - August 1, 2017 Category: Cardiology Authors: Seo ‐Won Choi, Bo‐Bae Kim, Dong‐Hyun Choi, Geon Park, Byung Chul Shin, Heesang Song, DongHun Kim, Dong‐Min Kim Tags: CLINICAL INVESTIGATIONS Source Type: research
Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation
Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long‐term anticoagulation. Multiple ...
Source: Clinical Cardiology - July 27, 2017 Category: Cardiology Authors: Rizma Jalees Bajwa, Lara Kovell, Jon R. Resar, Armin Arbab ‐Zadeh, Kaushik Mandal, Hugh Calkins, Ronald D. Berger Tags: REVIEW Source Type: research
Vitamin K antagonists with or without long ‐term antiplatelet therapy in outpatients with stable coronary artery disease and atrial fibrillation: Association with ischemic and bleeding events
ConclusionsIn this observational analysis, the use of APT in addition to OAC in patients with stable CAD and AF was not associated with lower risk of ischemic events but possibly with higher bleeding rates. Randomized trials are necessary to determine the optimal long‐term antithrombotic strategy.
Source: Clinical Cardiology - July 10, 2017 Category: Cardiology Authors: Gilles Lemesle, Gregory Ducrocq, Yedid Elbez, Eric Van Belle, Shinya Goto, Christopher P. Cannon, Christophe Bauters, Deepak L. Bhatt, Philippe Gabriel Steg, Tags: CLINICAL INVESTIGATIONS Source Type: research
Rationale and design of a randomized trial of apixaban vs warfarin to evaluate atherosclerotic calcification and vulnerable plaque progression
This study is a single‐center, prospective, randomized, open‐label study. From May 2014 to December 2015, 66 patients with nonvalvular AF who experienced VKA therapy were enrolled. Patients were randomized into either warfarin or apixaban cohorts and followed for 52 weeks. The primary objective is to compare the rate of change in coronary artery calcification (CAC) from baseline to follow‐up in apixaban vs warfarin cohorts. The key secondary objective is to compare the rate of incident plaques and quantitative changes in plaque types between patients randomized to either warfarin or apixaban cohorts using serial coro...
Source: Clinical Cardiology - July 1, 2017 Category: Cardiology Authors: Kazuhiro Osawa, Rine Nakanishi, Theingi Tiffany Win, Dong Li, Sina Rahmani, Negin Nezarat, Nasim Sheidaee, Matthew J. Budoff Tags: TRIAL DESIGNS Source Type: research
Cardiovascular adverse events in the drug ‐development program of bupropion for smoking cessation: A systematic retrospective adjudication effort
Conclusions
CV events in bupropion clinical trials for smoking cessation were uncommon, with no observed increase among subjects assigned to bupropion vs placebo. However, this effort was limited by a paucity of quality data.
Source: Clinical Cardiology - June 12, 2017 Category: Cardiology Authors: Jessie Kittle, Renato D. Lopes, Mingyan Huang, Marsha L. Marquess, Matthew D. Wilson, John Ascher, Alok Krishen, Vic Hasselblad, Brad J. Kolls, Matthew T. Roe, Darren K. McGuire, Stuart D. Russell, Kenneth W. Mahaffey Tags: CLINICAL INVESTIGATIONS Source Type: research
Relative efficacy and safety of ticagelor vs clopidogrel as a function of time to invasive management in non –ST‐segment elevation acute coronary syndrome in the PLATO trial
ConclusionsThe benefit of ticagrelor over clopidogrel was consistent in those undergoing early and late angiography, supporting upstream use of ticagrelor.
Source: Clinical Cardiology - June 9, 2017 Category: Cardiology Authors: Charles V. Pollack, Farideh Davoudi, Deborah B. Diercks, Richard C. Becker, Stefan K. James, Soo Teik Lim, Phillip J. Schulte, Jindrich Spinar, Philippe Gabriel Steg, Robert F. Storey, Anders Himmelmann, Lars Wallentin, Christopher P. Cannon, Tags: CLINICAL INVESTIGATIONS Source Type: research
Cost ‐effectiveness analysis of 30‐month vs 12‐month dual antiplatelet therapy with clopidogrel and aspirin after drug‐eluting stents in patients with acute coronary syndrome
Continuation of dual antiplatelet therapy (DAPT) beyond 1 year reduces late stent thrombosis and ischemic events after drug‐eluting stents (DES) but increases risk of bleeding. We hypothesized that extending DAPT from 12 months to 30 months in patients with acute coronary syndrome (ACS) after DES is cost‐effective. A lifelong decision‐analytic model was designed to simulate 2 antiplatelet strategies in event‐free ACS patients who had completed 12‐month DAPT after DES: aspirin monotherapy (75–162 mg daily) and continuation of DAPT (clopidogrel 75 mg daily plus aspirin 75–162 mg daily) for 18 months. Clinical e...
Source: Clinical Cardiology - June 1, 2017 Category: Cardiology Authors: Minghuan Jiang, Joyce H.S. You Tags: QUALITY AND OUTCOMES Source Type: research
Geographic variation and risk factors for systemic and limb ischemic events in patients with symptomatic peripheral artery disease: Insights from the REACH Registry
ConclusionsFour‐year systemic ischemic risk in patients with PAD and no history of stroke or transient ischemic attack remains high, and was mainly driven by cardiovascular mortality.
Source: Clinical Cardiology - May 18, 2017 Category: Cardiology Authors: J érémie Abtan, Deepak L. Bhatt, Yedid Elbez, Emmanuel Sorbets, Kim Eagle, Christopher M. Reid, Iris Baumgartner, David Wu, Mary E. Hanson, Hakima Hannachi, Puneet K. Singhal, Philippe Gabriel Steg, Gregory Ducrocq, Tags: CLINICAL INVESTIGATIONS Source Type: research
Low ‐flow/low‐gradient aortic stenosis—Still a diagnostic and therapeutic challenge
Aortic stenosis (AS) is the most frequently observed valvular heart disease. During the symptomatic stage, the rate of death increases dramatically, so that a precise diagnostic approach is taken to guide therapeutic options. Of patients with severe AS, 30% to 50% present with low‐flow/low‐gradient AS (LF/LGAS) status. This review focuses on LF/LGAS and the best diagnostic and therapeutic management in either classic LF/LGAS with reduced left ventricular ejection fraction (LVEF) or paradoxical LF/LGAS with preserved LVEF. Current literature demonstrates that in classic LF/LGAS it is crucial to rule out a pseudo‐sever...
Source: Clinical Cardiology - May 1, 2017 Category: Cardiology Authors: Anja Vogelgesang, Gerd Hasenfuss, Claudius Jacobshagen Tags: Review Source Type: research
Oral anticoagulation management in patients with atrial fibrillation undergoing cardiac implantable electronic device implantation
ConclusionsManagement of anticoagulation among AF patients undergoing CIED implantation is highly variable, with OAC being interrupted in more than half of both warfarin‐ and NOAC‐treated patients. Bleeding and stroke events were infrequent in both warfarin and NOAC‐treated patients.
Source: Clinical Cardiology - May 1, 2017 Category: Cardiology Authors: Eric Black ‐Maier, Sunghee Kim, Benjamin A. Steinberg, Gregg C. Fonarow, James V. Freeman, Peter R. Kowey, Jack Ansell, Bernard J. Gersh, Kenneth W. Mahaffey, Gerald Naccarelli, Elaine M. Hylek, Alan S. Go, Eric D. Peterson, Jonathan P. Piccini, Tags: CLINICAL INVESTIGATIONS Source Type: research
Aspirin and the risk of cardiovascular events in atherosclerosis patients with and without prior ischemic events
ConclusionsIn this observational analysis of outpatients with stable atherosclerosis, aspirin was marginally beneficial among patients with a prior ischemic event; however, there was no apparent benefit among those with no prior ischemic event.
Source: Clinical Cardiology - May 1, 2017 Category: Cardiology Authors: Anthony A. Bavry, Islam Y. Elgendy, Yedid Elbez, Ahmed N. Mahmoud, Emmanuel Sorbets, Philippe Gabriel Steg, Deepak L. Bhatt, Tags: CLINICAL INVESTIGATIONS Source Type: research
Peripheral artery disease and risk of adverse outcomes in heart failure with preserved ejection fraction
Conclusions
PAD increases the risk for adverse outcomes in HFpEF and is associated with HF rehospitalization. Practitioners should be aware of the inherent risk associated with PAD in HFpEF.
Source: Clinical Cardiology - April 26, 2017 Category: Cardiology Authors: Pratik B. Sandesara, Muhammad Hammadah, Ayman Samman ‐Tahhan, Heval M. Kelli, Wesley T. O'Neal Tags: CLINICAL INVESTIGATIONS Source Type: research
Procedural success and intra ‐hospital outcome related to left atrial appendage morphology in patients that receive an interventional left atrial appendage closure
ConclusionsIrrespective of the varying morphological presentation of the LAA, the procedural success rates, interventional characteristics, and safety events did not significantly differ among patients receiving an interventional LAA closure.
Source: Clinical Cardiology - April 13, 2017 Category: Cardiology Authors: Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Ibrahim El ‐Battrawy, Uzair Ansari, Ishar‐Singh Gill, Martin Borggrefe, Ibrahim Akin Tags: CLINICAL INVESTIGATIONS Source Type: research
