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Source: Neurobiology of Disease
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Total 168 results found since Jan 2013.
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research
The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage
Neurobiol Dis. 2023 Sep 6:106282. doi: 10.1016/j.nbd.2023.106282. Online ahead of print.ABSTRACTStroke is the second leading cause of death worldwide and has two major subtypes: ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of ischemic stroke and intracerebral hemorrhage (ICH), contributing to the extent of brain injury but also in its repair. Neuroinflammation is intricately linked to the extracellular matrix (ECM), which is profoundly altered after brain injury and in aging. In the early stages after ischemic stroke and ICH, immune cells are involved in the deposition and remodeling...
Source: Neurobiology of Disease - September 8, 2023 Category: Neurology Authors: Hongmin Li Samira Ghorbani Chang-Chun Ling V Wee Yong Mengzhou Xue Source Type: research
20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3
This study highlights generation of potential defects at the CCM3-affected brain endothelial barrier which may underlie prolonged vascular leakiness.PMID:37652184 | DOI:10.1016/j.nbd.2023.106277
Source: Neurobiology of Disease - August 31, 2023 Category: Neurology Authors: Chelsea M Phillips Allison M Johnson Svetlana M Stamatovic Richard F Keep Anuska V Andjelkovic Source Type: research
METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis
Neurobiol Dis. 2023 Aug 2:106253. doi: 10.1016/j.nbd.2023.106253. Online ahead of print.ABSTRACTN6-methyladenosine (m6A) plays a crucial role in ischemic stroke, whereas the role of methyltransferase-like 14 (METTL14) in ischemic stroke remains unknown. A model of middle cerebral artery occlusion (MCAO) in rats and oxygen-glucose deprivation/reperfusion (OGD/R) model in HAPI cells were used to simulate ischemic stroke in vivo and in vitro. We found that METTL14 level was upregulated in microglia/macrophage after MCAO and OGD/R. METTL14 enhanced the expression of KAT3B by promoting the m6A modification of KAT3B mRNA. STING ...
Source: Neurobiology of Disease - August 4, 2023 Category: Neurology Authors: Yamei Li Jiacen Li Qian Yu Ling Ji Bo Peng Source Type: research
Preventing development of post-stroke hyperexcitability by optogenetic or pharmacological stimulation of cortical excitatory activity
Neurobiol Dis. 2023 Jul 17;184:106233. doi: 10.1016/j.nbd.2023.106233. Online ahead of print.ABSTRACTStroke is the most common cause of acquired epilepsy, but treatment for preventing the development of post-stroke epilepsy is still unavailable. Since stroke results in neuronal damage and death as well as initial loss of activity in the affected brain region, homeostatic plasticity may be trigged and contribute to an increase in network hyperexcitability that underlies epileptogenesis. Correspondingly, enhancing brain activity may inhibit hyperexcitability from enhanced homeostatic plasticity and prevent post-stroke epilep...
Source: Neurobiology of Disease - July 19, 2023 Category: Neurology Authors: Yadav Adhikari Cun-Gen Ma Zhi Chai Xiaoming Jin Source Type: research
New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery
Neurobiol Dis. 2023 Jun 13:106200. doi: 10.1016/j.nbd.2023.106200. Online ahead of print.ABSTRACTOligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe damage to these vulnerable cells through excitotoxicity, oxidative stress, inflammation, and mitochondrial dysfunction, leading to axonal dystrophy, neuronal dysfunction, and neurological impairments. OLs damage can result in demyelination and myelination disorders, severely impacting axonal function, structure, metabolism, and survival. Adult-onset stroke, per...
Source: Neurobiology of Disease - June 15, 2023 Category: Neurology Authors: Shuangfeng Huang Changhong Ren Yumin Luo Yuchuan Ding Xunming Ji Sijie Li Source Type: research
Natural killer cells in aging and age-related diseases
Neurobiol Dis. 2023 May 18:106156. doi: 10.1016/j.nbd.2023.106156. Online ahead of print.ABSTRACTAging leads to escalated systemic inflammation. As the sentinel of immune system, natural killer (NK) cells are early responders that sense cues and signals from target organs and swiftly orchestrate local inflammation upon their arrival. Emerging evidence indicates a profound role of NK cells in the initiation and evolution of neuroinflammation in aging and age-related diseases. Here we discuss recent advances in NK cell biology and the organ-specific features of NK cells in normal brain aging, Alzheimer's disease, Parkinson's...
Source: Neurobiology of Disease - May 20, 2023 Category: Neurology Authors: Caiyun Qi Qiang Liu Source Type: research
