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Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia
CONCLUSIONS: These results indicate that repeated systemic administration of MSCs over 3 weeks resulted in greater functional improvement as compared to single administration and/or vehicle infusion. In addition, administration of MSCs is associated with promotion of interhemispheric connectivity through the CC in the chronic phase of cerebral infarction.PMID:34861644 | DOI:10.3171/2021.8.JNS21687
Source: Journal of Neurosurgery - December 3, 2021 Category: Neurosurgery Authors: Mitsuhiro Takemura Masanori Sasaki Yuko Kataoka-Sasaki Ryo Kiyose Hiroshi Nagahama Shinichi Oka Ryo Ukai Takahiro Yokoyama Jeffery D Kocsis Tetsuya Ueba Osamu Honmou Source Type: research

Brain repair by hematopoietic growth factors in the subacute phase of traumatic brain injury.
CONCLUSIONS SCF + G-CSF treatment in the subacute phase of TBI restored TBI-impaired spatial learning and memory, prevented posttraumatic anxiety and risk-taking behavior, inhibited TBI-induced neurodegeneration, and enhanced neural network remodeling. These findings suggest the therapeutic potential of hematopoietic growth factors for brain repair in the subacute phase of TBI. PMID: 29372883 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 26, 2018 Category: Neurosurgery Authors: Toshkezi G, Kyle M, Longo SL, Chin LS, Zhao LR Tags: J Neurosurg Source Type: research