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Source: Journal of Neurosurgery
Drug: Lithium
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Total 1 results found since Jan 2013.
Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury.
Conclusions Cotreatment with subeffective doses of lithium and VPA significantly attenuated TBI-induced brain lesion, BBB disruption, and neurodegeneration, and robustly improved long-term functional recovery. These findings suggest that potentiating histone acetylation by HDAC inhibition is probably part of the mechanism underlying the beneficial effects associated with this combined treatment for TBI. Because both lithium and VPA have a long history of safe clinical use, the results suggest that using a combination of these 2 agents at subtherapeutic doses to treat patients with TBI may also reduce side effects and enhan...
Source: Journal of Neurosurgery - July 12, 2013 Category: Neurosurgery Authors: Yu F, Wang Z, Tanaka M, Chiu CT, Leeds P, Zhang Y, Chuang DM Tags: J Neurosurg Source Type: research
